Güncel Gönderiler: European Journal of Life Sciences
Toplam kayıt 41, listelenen: 1-20
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Investigation of dual AChE/MAO inhibitory activities of new morpholine and piperazine structured compounds
(Anadolu Üniversitesi, 2024)In this study, a series of new compounds containing piperazine and morpholine rings were synthesized. Characterization studies of the obtained compounds were carried out with the help of HRMS, 1H-NMR and 13C-NMR spectroscopic ... -
Synthesis of new 1,3,4-thiadiazole derivatives, investigation of their AChE effects
(Anadolu Üniversitesi, 2024)Alzheimer’s disease (AD) is the most common cause of dementia and one of the most prevalent neurodegenerative diseases. It begins with mild cognitive impairment and progressively affects all aspects of the patient’s life ... -
Synthesis of some benzothiazole-piperazine derivatives, investigation by in vitro and molecular modelling for hMAO inhibitory activities
(Anadolu Üniversitesi, 2024)Monoamine oxidase (MAO) is an enzyme that helps regulate the functions of intracellular amines, as well as chemicals such as dopamine, serotonin and norepinephrine, in the brain and its tissues. Active substances that are ... -
Synthesis of a new thiadiazole-benzodioxole derivative, investigation of acetylcholinesterase inhibition with in vitro and in silico studies
(2024)Alzheimer’s disease is a progressive and degenerative brain disease that negatively affects people’s lives and reduces cognitive and sensory human functions. Today, there are active ingredients that work on Alzheimer’s ... -
Phytochemical quality analysis of commercial preparations containing Echinacea purpurea
(Anadolu Üniversitesi, 2024)Echinacea species have been medicinally important plants from the past to the present. Echinacea is used in many diseases, especially cold and wound treatment. The root, flower, and leaf parts of the plant, especially the ... -
Review of an up-to-date, emphatic, and concise perspective on e-cigarettes
(Anadolu Üniversitesi, 2024)Electronic cigarettes entered the market in 2007 as an alternative to conventional tobacco products, and their use has increased significantly worldwide. Due to the emergence of various harmful effects and attracting ... -
Comparison of apoptotic effects of lupeol on A549 and C6 cell lines
(Anadolu Üniversitesi, 2024)Lupeol compound is a cyclic triterpene alcohol that is widely found in plants. The compound lupeol has been reported to exhibit antitumor, anti-inflammatory, anxiolytic, neuroprotective and hepatoprotective effects. Recent ... -
Evaluating attitudes of pharmacy students toward pharmaceutical side effect pictograms: Ankara sample
(Anadolu Üniversitesi, 2024)Pictograms are graphic symbols that facilitate international communications and express objects and the meaning of these objects. Using pictograms in health is essential to informing patients, especially in cases such as ... -
COX inhibitory profiles of a series of thiadiazole-benzothiazole hybrids
(Anadolu Üniversitesi, 2024)In an endeavour to identify small molecule COX-1 inhibitors, a colorimetric assay protocol was applied for the in vitro evaluation of COX-1 and 2 inhibitory potential of a series of thiadiazole-benzothiazole hybrids. The ... -
The prevalence of helminth eggs in raw vegetables from street markets in Eskişehir, Türkiye
(Anadolu Üniversitesi, 2024)This research was performed on a total of 120 vegetables, with 12 samples taken from each available Eskişehir district markets. In this study, we aimed to determine the presence of contamination from helminth eggs in 10 ... -
Pharmaceutical supply chain: The importance of outsourcing
(Anadolu Üniversitesi, 2023)A vast web of organizations, companies, and teams involved in creating, researching, and producing drugs and associated products makes up the pharmaceutical sector. In this context, the term “supply chain” refers to the ... -
Evaluation of volatile components of Achillea millefolium L. essential oil
(Anadolu Üniversitesi, 2023)The genus Achillea (Asteraceae) is distributed in Europe and the Middle East and has approximately 140 endemic species. There are 40 Achillea sp. in the Turkish flora and 20 of them are endemic. This genus has a widespread ... -
Synthesis of thiazole derivatives as cholinesterase inhibitors with antioxidant activity
(Anadolu Üniversitesi, 2023)In the present research, we synthesized two unique series of thiazole compounds having 5-bromothiophene and 3-methylthiophene (2a-2f) in their structure. After that, spectroscopic methods were used to analyze the chemical ... -
HPLC method for simultaneous quantification of lumacaftor and ivacaftor bulk and pharmaceutical formulations
(Anadolu Üniversitesi, 2023)In 2015, the Food and Drug Administration granted approval for the use of lumacaftor 200 mg and ivacaftor 125 mg in the treatment of cystic fibrosis patients who possess the F508del mutation, namely those who are 12 years ... -
Volatile components of Ferulago aucheri Boiss. (Apiaceae)
(Anadolu Üniversitesi, 2023)Ferulago aucheri Boiss, which belongs to the Apiaceae family, is distributed from Türkiye to the Caucasus. Its chemical composition may vary depending on the region where it grows, climate conditions and topography. Essential ... -
Determination of cytotoxic, antioxidant activities and LC/MS-MS profiles of three endemic Verbascum L. species
(Anadolu Üniversitesi, 2023)The Verbascum genus includes many species used in folk medicine or the treatment of various diseases. In this study, the cytotoxic, antioxidant activity, and LC/MS-MS profiles of three Verbascum species, which are endemic ... -
Oral medicine administration errors in a patient with an enteral feeding tube
(Anadolu Üniversitesi, 2023)Proper nutrition is vital for all patients with an expected lifespan. It is strongly recommended that patients whose oral intake is impaired or suspected to be impaired should be provided nutritional support. Concurrent ... -
Etiopathogenesis of depression and experimental depression models used in preclinical studies
(Anadolu Üniversitesi, 2023)Depression is the most frequent psychiatric illness among mood disorders, affecting approximately 10% of adults. Especially recurrent and moderate/severe depression can become a serious public health problem by impairing ... -
Screening of new morpholine dithiocarbamate derivatives bearing benzimidazole moiety for anticholinesterase potential
(Anadolu Üniversitesi, 2023)Alzheimer’s disease (AD) is basically associated with disturbances of cholinesterase metabolism which result in acetylcholine deficiency. Target of acetylcholinesterase (AChE) inhibitors used in symptomatic therapy of ... -
Evaluation of in vitro hepatotoxicity of perampanel in comparison with carbamazepine: old versus new
(Anadolu Üniversitesi, 2023)Since the liver metabolizes many drugs, including antiepileptics, this organ is the main target of drug-induced damage. There is very little data on hepatotoxicity due to carbamazepine and perampanel metabolized in the ...
