• The blood-brain barrier: a focus on neurovascular unit components 

  Can, Betül; Alataş, İ. Özkan (Anadolu Üniversitesi, 2024)

  The blood–brain barrier (BBB) provides an optimum environment for neurons by ensuring the integrity and homeostasis of highly fragile brain cells under physiological conditions, protecting the brain from changes in the ...

• An examination of natural and synthetic tyrosinase inhibitors 

  Demirdiş, Gizem (Anadolu Üniversitesi, 2024)

  The enzyme responsible for this process is known as tyrosinase, which is sometimes referred to as polyphenol oxidase, monophenol oxidase, phenolase, or catecholase. It is present in humans, plants, microbes, and fungi. ...

• Investigation of the essential oil composition and biological activities of the essential oil and extracts of the aerial parts of Seseli libanotis W.D.J. Koch 

  Anadolu Üniversitesi; 0000-0002-8743-7234; 0000-0002-9375-0294; 0000-0003-4826-5975; 0000-0002-3675-1450; 0000-0003-2710-0231; Temiz, Burak; Kürkçüoğlu, Mine; Ağalar, Hale Gamze; Duran, Ahmet; Başer, Kemal Hüsnü Can (Anadolu Üniversitesi, 2024)

  In this study, the essential oil and various extracts (n-hexane, ethyl acetate, and methanol) were obtained from Seseli libanotis W.D.J. Koch aerial parts. The essential oil was obtained via hydrodistillation and subjected ...

• Synthesis of novel thiazole derivatives against Alzheimer’s disease and investigation of their cholinesterase inhibition and antioxidant properties 

  Karakaya, Abdüllatif; Erçetin, Tuğba (Anadolu Üniversitesi, 2024)

  In this study, 7 new thiazole derivatives were synthesized. Cholinesterase inhibition and antioxidant properties were examined to understand whether the synthesized compounds were anti-Alzheimer drug candidates. The ...

• Quantitative determination of rivaroxaban in pharmaceutical formulations by ultra performance liquid chromatography 

  Kozanlı, Murat (Anadolu Üniversitesi, 2024)

  Rivaroxaban, which is a factor Xa inhibitor, effectively prevents clot formation in cardiovasculary system. In this study, a novel UPLC method was developed to provide an accurate, sensitive, fast, and reliable way for ...

• Investigation of dual AChE/MAO inhibitory activities of new morpholine and piperazine structured compounds 

  Kurban, Berkant (Anadolu Üniversitesi, 2024)

  In this study, a series of new compounds containing piperazine and morpholine rings were synthesized. Characterization studies of the obtained compounds were carried out with the help of HRMS, 1H-NMR and 13C-NMR spectroscopic ...

• Synthesis of new 1,3,4-thiadiazole derivatives, investigation of their AChE effects 

  Anadolu Üniversitesi; 0000-0003-3169-2284; 0000-0002-0499-436X; 0000-0002-0151-6266; 0000-0003-2252-0923; Cebeci, Ayşe Nur; Osmaniye, Derya; Sağlık Özkan, Begüm Nurpelin; Kaplancıklı, Zafer Asım (Anadolu Üniversitesi, 2024)

  Alzheimer’s disease (AD) is the most common cause of dementia and one of the most prevalent neurodegenerative diseases. It begins with mild cognitive impairment and progressively affects all aspects of the patient’s life ...

• Synthesis of some benzothiazole-piperazine derivatives, investigation by in vitro and molecular modelling for hMAO inhibitory activities 

  Göktaş, Bünyamin; Uslu, Harun (Anadolu Üniversitesi, 2024)

  Monoamine oxidase (MAO) is an enzyme that helps regulate the functions of intracellular amines, as well as chemicals such as dopamine, serotonin and norepinephrine, in the brain and its tissues. Active substances that are ...

• Synthesis of a new thiadiazole-benzodioxole derivative, investigation of acetylcholinesterase inhibition with in vitro and in silico studies 

  Göktaş, Bünyamin; Uslu, Harun (2024)

  Alzheimer’s disease is a progressive and degenerative brain disease that negatively affects people’s lives and reduces cognitive and sensory human functions. Today, there are active ingredients that work on Alzheimer’s ...

• Phytochemical quality analysis of commercial preparations containing Echinacea purpurea 

  Karadağ, Ayşe Esra; Baydar, Rengin; Kırcı, Damla (Anadolu Üniversitesi, 2024)

  Echinacea species have been medicinally important plants from the past to the present. Echinacea is used in many diseases, especially cold and wound treatment. The root, flower, and leaf parts of the plant, especially the ...

• Review of an up-to-date, emphatic, and concise perspective on e-cigarettes 

  Anadolu Üniversitesi; 0000-0002-5492-0457; 0009-0007-6708-1166; 0000-0003-3692-163X; 0000-0003-0280-518X; Özcan, Saniye; Öğüt, Egemen Güvenç; Levent, Serkan; Öncü Can, Nafiz (Anadolu Üniversitesi, 2024)

  Electronic cigarettes entered the market in 2007 as an alternative to conventional tobacco products, and their use has increased significantly worldwide. Due to the emergence of various harmful effects and attracting ...

• Comparison of apoptotic effects of lupeol on A549 and C6 cell lines 

  Ertorun, İpek (Anadolu Üniversitesi, 2024)

  Lupeol compound is a cyclic triterpene alcohol that is widely found in plants. The compound lupeol has been reported to exhibit antitumor, anti-inflammatory, anxiolytic, neuroprotective and hepatoprotective effects. Recent ...

• Evaluating attitudes of pharmacy students toward pharmaceutical side effect pictograms: Ankara sample 

  Paşa, Yasenya; Arslan, Miray; Tarhan, Nilay; Şar, Sevgi (Anadolu Üniversitesi, 2024)

  Pictograms are graphic symbols that facilitate international communications and express objects and the meaning of these objects. Using pictograms in health is essential to informing patients, especially in cases such as ...

• COX inhibitory profiles of a series of thiadiazole-benzothiazole hybrids 

  Anadolu Üniversitesi; 0000-0003-0280-5550; 0000-0002-5233-1165; Özdemir, Ahmet; Temel, Halide Edip (Anadolu Üniversitesi, 2024)

  In an endeavour to identify small molecule COX-1 inhibitors, a colorimetric assay protocol was applied for the in vitro evaluation of COX-1 and 2 inhibitory potential of a series of thiadiazole-benzothiazole hybrids. The ...

• The prevalence of helminth eggs in raw vegetables from street markets in Eskişehir, Türkiye 

  Kartal, Kürşat; Güzel, Hakan (Anadolu Üniversitesi, 2024)

  This research was performed on a total of 120 vegetables, with 12 samples taken from each available Eskişehir district markets. In this study, we aimed to determine the presence of contamination from helminth eggs in 10 ...

• Pharmaceutical supply chain: The importance of outsourcing 

  Akbal Dağistan, Özlem (Anadolu Üniversitesi, 2023)

  A vast web of organizations, companies, and teams involved in creating, researching, and producing drugs and associated products makes up the pharmaceutical sector. In this context, the term “supply chain” refers to the ...

• Evaluation of volatile components of Achillea millefolium L. essential oil 

  Kırcı, Damla (Anadolu Üniversitesi, 2023)

  The genus Achillea (Asteraceae) is distributed in Europe and the Middle East and has approximately 140 endemic species. There are 40 Achillea sp. in the Turkish flora and 20 of them are endemic. This genus has a widespread ...

• Synthesis of thiazole derivatives as cholinesterase inhibitors with antioxidant activity 

  Erçetin, Tuğba (Anadolu Üniversitesi, 2023)

  In the present research, we synthesized two unique series of thiazole compounds having 5-bromothiophene and 3-methylthiophene (2a-2f) in their structure. After that, spectroscopic methods were used to analyze the chemical ...

• HPLC method for simultaneous quantification of lumacaftor and ivacaftor bulk and pharmaceutical formulations 

  Anadolu Üniversitesi; 0000-0002-5492-0457; 0000-0001-8467-478X; 0000-0003-3692-163X; Özcan, Saniye; Elbiş, Abeer; Levent, Serkan (Anadolu Üniversitesi, 2023)

  In 2015, the Food and Drug Administration granted approval for the use of lumacaftor 200 mg and ivacaftor 125 mg in the treatment of cystic fibrosis patients who possess the F508del mutation, namely those who are 12 years ...

• Volatile components of Ferulago aucheri Boiss. (Apiaceae) 

  Ocak, Esma; Eğin Kolata, Filiz (Anadolu Üniversitesi, 2023)

  Ferulago aucheri Boiss, which belongs to the Apiaceae family, is distributed from Türkiye to the Caucasus. Its chemical composition may vary depending on the region where it grows, climate conditions and topography. Essential ...

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