Güncel Gönderiler: Makale Koleksiyonu
Toplam kayıt 86, listelenen: 41-60
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Towards Novel Anti-tumor Strategies for Hepatic Cancer: epsilon-Viniferin in Combination with Vincristine Displays Pharmacodynamic Synergy at Lower Doses in HepG2 Cells
(Mary Ann Liebert, Inc, 2014)Hepatocellular carcinoma is the fifth most common cancer and the third leading cause of cancer-related deaths worldwide. The efficacy of novel combination treatments are increasingly evaluated with use of integrative biology ... -
Cytotoxicity Screening, Antioxidant Activity and Phenolic Profile of Two Species of Thymus on Human Cervical and Ovarian Cancer Cells Lines in Vitro
(Parlar Scientific Publications (PSP), 2017)The aim of this study was to determine of cytotoxic, antioxidant activity and phenolic profile of the two species of Thymus which are Thymus sipyleus Boiss. and Thymus leucostomus Hausskn. et Velen. (endemic). For this ... -
Synthesis and Evaluation of New Dithiocarbamic Acid 6,11-Dioxo-6,11-dihydro-1H-anthra[1,2-d]-imidazol-2-yl Methyl Esters
(Wiley-V C H Verlag GMBH, 2015)A novel series of dithiocarbamic acid 6,11-dioxo-6,11-dihydro-1H-anthra[1,2-d]imidazol-2-yl methyl esters were synthesized and their cytotoxic and apoptotic activities were evaluated on HeLa cells. Some of these compounds ... -
Vincristine and epsilon-viniferine-loaded PLGA-b-PEG nanoparticles: pharmaceutical characteristics, cellular uptake and cytotoxicity
(Taylor & Francis LTD, 2017)The objective of this study was to prepare the epsilon-viniferine and vincristine-loaded PLGA-b-PEG nanoparticle and to investigate advantages of these formulations on the cytotoxicity of HepG2 cells. Prepared nanoparticle ... -
Effects of fibronectin and type IV collagen on osteosarcoma cell apoptosis
(Natl Inst Science Communication-Niscair, 2013)The aims of this study are the investigation of the effects of fibronectin and type IV collagen extracellular matrix proteins and the role of caspase-3 and -9 on cis-platin induced U2-OS apoptosis were studied. First the ... -
Ultrastructural Examination of Intracellular Calcium Changes in Ovarian Cancer
(Parlar Scientific Publications (PSP), 2017)In this study, following the fibronectin-coated integrin activation in ovarian cancer cells (SKOV-3), endoplasmic reticulum (ER) stress was generated by intracellular calcium increase and then possible apoptotic effects ... -
Apoptotic Effects of Some Thiohydantoin Derivatives
(Turkish Biochem Soc, 2010)Objectives: The aim of this study is to investigate the effects of newly synthesized 3-phenly-and 3-(4-methoxyphenyl)-2-thiohydantoin derivatives on 5RP7 ve CO25 cell apoptosis. Methods and Materials: Thiohydantoin derivatives ... -
Fe3O4 Nanopowders: Genomic and Apoptotic Evaluations on A549 Lung Adenocarcinoma Cell Line
(Routledge Journals, Taylor & Francis LTD, 2019)The magnetite nanoparticles are progressively used in a wide range of biological applications. In the present study, we purposed to show apoptosis-inducing ability of Fe3O4 nanopowders on A549 cells. In addition, the toxic ... -
A Comprehensive Study on Thiadiazole-Based Anticancer Agents Inducing Cell Cycle Arrest and Apoptosis/Necrosis Through Suppression of Akt Activity in Lung Adenocarcinoma and Glioma Cells
(Turkish Pharmacists Assoc, 2019)Objectives: Akt is considered as an attractive target for anticancer drug discovery and development and therefore extensive efforts have been devoted to the discovery of new potent anticancer agents targeting Akt. Materials ... -
The effects of atorvastatin on antioxidant/antiinflammatory properties of HDLs in hypercholesterolemics
(Tubitak Scientific & Technical Research Council Turkey, 2015)Background/aim: Hypercholesterolemia is characterized by changes in lipid profile, nitric oxide pathway, and oxidative stress markers, but functions of high-density lipoprotein (HDL) were not well established in ... -
Induction of apoptosis in lung adenocarcinoma and glioma cells by some oxadiazole derivatives
(Springer Birkhauser, 2014)Oxadiazoles have received much attention due to their wide range of biological activities including antitumor activity. In this study, we aimed to study apoptotic effects of some 1,3,4-oxadiazole derivatives on human lung ... -
Escin reduces cell proliferation and induces apoptosis on glioma and lung adenocarcinoma cell lines
(Springer, 2015)Aesculus hippocastanum (the horse chestnut) seed extract has a wide variety of biochemical and pharmacological effects including anti-inflammatory, antianalgesic, and antipyretic activities. The main active compound of ... -
Apoptotic effects of some carbazole derivatives on lung carcinoma and glioma cell lines
(Springer Birkhauser, 2013)In this study, we aimed to study the apoptotic effects of 2-[(9-ethyl-9H-carbazol-3-yl)amino]-2-oxoethyl N,N-disubstituted dithiocarbamates on A549 lung carcinoma and C6 glioma cell lines. Cytotoxicity analyses of DNA ... -
Oxidative and inflammatory status and HDL functions of obese pre and post menopausal women
(Walter De Gruyter GMBH, 2014)Objective: Obesity and age related vascular changes coupled with the effect of estrogen withdrawal increases predisposition to atherosclerosis in postmenopausal women. But the functions of high density lipoprotein (HDL) ... -
Cytotoxic, Apoptotic and DNA Synthesis Inhibitory Effects of Some Thiazole Derivatives
(Bentham Science Publ LTD, 2017)Background: Cancer is one of the leading causes of morbidity and mortality worldwide and extensive efforts have been devoted to the discovery of new anticancer agents. In the last few decades, the clinical efficacy of ... -
Cytotoxic, Antiproliferative and Apoptotic Effects of Perillyl Alcohol and Its Biotransformation Metabolite on A549 and HepG2 Cancer Cell Lines
(Bentham Science Publ LTD, 2017)Background: A monoterpene, perillyl alcohol, has attracted attention in medicinal chemistry since it exhibited chemo-preventive and therapeutic properties against a variety of cancers. Objective: In the present work, it ... -
In vitro effects of alpha-tocopherol and ascorbic acid on antioxidant characteristics of HDL
(Turkish Biochem Soc, 2011)Aim: High density lipoprotein (HDL) retards accumulation of proinflammatuar oxidized phospholipids in low density lipoproteins (LDL) and have a capacity on inhibition of oxidative modification. These antioxidant and ... -
Synthesis, biological evaluation and in silico studies of novel N-substituted phthalazine sulfonamide compounds as potent carbonic anhydrase and acetylcholinesterase inhibitors
(Academic Press Inc Elsevier Science, 2019)The synthesis, characterization and biological evaluation of a series of novel N-substituted phthalazine sulfonamide (5a-1) are disclosed. Phthalazines which are nitrogen-containing heterocyclic compounds are biologically ... -
Inhibition effects of quinones on aldose reductase: Antidiabetic properties
(Elsevier, 2019)Diabetes mellitus is a chronic metabolic disease characterized by abnormal glucose metabolism. Aldose reductase (AR) is the first enzyme in the polyol pathway and converts glucose to sorbitol. It plays a vital role as a ... -
Anti-diabetic Properties of Calcium Channel Blockers: Inhibition Effects on Aldose Reductase Enzyme Activity
(Springer, 2019)Aldose reductase (AR) belongs to NADPH-dependent oxidoreductases and converts glucose to sorbitol in the polyol pathway. AR inhibition is essential to prevent diabetic complications. Here, AR was purified from sheep kidney ...
