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Purification of glutathione reductase from some tissues of Capoeta umblaand the inhibitory effects of some metal ions on enzyme activity
(2021)The aim of this study was to determine the in vitro inhibitory effects of some metal ions (silver ion (Ag+), cadmium ion (Cd2+), cobalt ion (Co2+), copper ion (Cu2+), nickel ion (Ni2+), lead ion (Pb2+) ... -
Design, synthesis and biological evaluation of new bis(thiosemicarbazone) derivatives as potential targeted anticancer agents for non-small cell lung cancer
(2020)Thiosemicarbazonesrepresent an important class of ligandsfortargeted therapyof many types of cancer including non-small celllung cancer. In order to identify potential antitumoragentsfor targeted therapy oflung cancer, new ... -
The behavior of some chalcones on acetylcholinesterase and carbonic anhydrase activity
(Taylor and Francis Ltd, 2019)Carbonic anhydrase (CA) has a key role in respiration, carbon dioxide and bicarbonate transport. Acetylcholinesterase (AChE) is a serine hydrolase and mostly abundant at neuromuscular junctions and cholinergic brain synapses. ... -
In vitro toxicity effects of some insecticides on gilthead sea bream (Sparus aurata) liver glucose 6-phosphate dehydrogenase
(Nobel Science and Research Center, 2016)In this study, effects of some insecticides (cypermethrin, deltamethrin, dichlorvos, imidacloprid and lambda-cyhalothrin) on glucose 6-phosphate dehydrogenase (D-glucose-6-phosphate: NADP+ oksidoreductase, EC 1.1.1.49; ... -
Purification and characterization of nitric oxide synthase from bovine kidney and investigating drug-induced toxicities of some antibiotics on the enzyme activity
(Bentham Science Publishers B.V., 2017)Introduction: Broad spectrums of antibiotics are widely used in the treatment of bacterial infections, particularly causing Staphylococcus aureus. These drugs have high acute renal injury (AKI) potency due to an increase ... -
Purification of glucose 6-phosphate dehydrogenase from gilthead sea bream (Sparus aurata) gill and liver tissues and inhibition effects of some metal ions on enzyme activity
(Parlar Scientific Publications, 2017)Fish is one of the most valuable protein sources and vulnerable to all environmental pollution including metals. Metals play vital roles in enzyme activities and other metabolic events with their bioaccumulative and ... -
Inhibition of Human Serum Paraoxonase-I with Antimycotic Drugs: In Vitro and In Silico Studies
(Humana Press Inc., 2019)Drugs show their pharmacological effects by inhibiting or activating enzymes. Therefore, enzyme inhibitors have an essential place in the drug design for numerous different sorts of diseases, i.e., cardiovascular, cancer, ... -
NO levels in diabetes mellitus: Effects of l-NAME and insulin on LCAT, Na+/K+ ATPase activity and lipid profile
(Elsevier Ltd, 2011)Objectives: Diabetes mellitus (DM) is a chronic disease and one of the most important health problems. Several factors may be responsible for the complications of diabetes mellitus including alterations in the activities ... -
Effects of lipoprotein-associated phospholipase A2 on arginase/nitric oxide pathway in hemodialysis patients
(2012)Lipoprotein-associated phospholipase A2 (Lp-PLA2) and arginase are recently described inflammatory biomarkers associated with cardiovascular disease. In this study, we aimed to investigate the possible effects of serum ... -
The effects of captopril and losartan on erythrocyte membrane Na1+/K1+ - ATPase activity in experimental diabetes mellitus
(2007)Diabetes mellitus induces a decrease in sodium potassium-adenosine triphosphatase (Na+/K+ - ATPase) activity in several tissues in the rat and red blood cells (RBC) and nervous tissue in human patients. This decrease in ... -
The effects of some phenanthroline ruthenium (II) complexes on A549 cell proliferation [Bazi{dotless} fenantrolin rutenyum (II) komplekslerinin a549 hücre çogalmasi{dotless} üzerine etkileri]
(2013)In recent years, ruthenium (II) complexes have increasingly attracted the interest of researchers because of their high antitumor activities that are usually related to DNA binding. Here, we synthesized two ruthenium (II) ... -
The effects of carvacrol on apoptosis of H-ras and N-ras transformed cell lines [Karvakrol'ün H-ras ve N-ras transform hücre apoptozu üzerine etkileri]
(2011)Carvacrol is a phenolic monoterpen found in Thyme plant which is used as a source of flavour in food. The aim of this study was to investigate apoptotic effects of carvacrol on H-ras transformed 5RP7 and N-ras transformed ... -
The effects of atorvastatin on antioxidant/antiinfammatory properties of HDLs in hypercholesterolemics
(2015)Background/aim: Hypercholesterolemia is characterized by changes in lipid profle, nitric oxide pathway, and oxidative stress markers, but functions of high-density lipoprotein (HDL) were not well established in ... -
Evaluation of Inhibition Effects of Some Cardiovascular Therapeutics on Human Erythrocyte Carbonic Anhydrase Isoenzymes
(2018)Carbonic anhydrase enzyme plays a vital role in metabolic events such as acid-base regulation and respiration. In our research, it is tried to determine the inhibitory influences of the cardiovascular therapeutics esmolol ... -
Akut ve Kronik Sigara İçen Genç Bireylerde Proinflamatuar Durumda HDL Fonksiyonlarının Önemi Nedir?
(2017)Amaç: Sigara içimi, kardiyovasküler hastalıkların en önemli ve önlenebilir risk faktörlerinden biridir. Okside LDL, kardiyovasküler hastalıklarda artış gösterir. Normal yüksek dansiteli lipoprotein (HDL), LDL'yi oksidasyondan ... -
The effects of 1,3 bis (heteroaryl substitued) benzene derivatives on apoptosis of N-ras transformed mouse skeletal muscle cell [1,3-Bi·s (heteroari·l sübsti·tüe) benzen türevleri·ni·n N-ras transform fare kasi hücre apoptozu üzeri·ne etki·leri·]
(2005)Increasing number of the cells, results of excess divicing of the cells, is balanced by apoptosis which causes elimination of old cells and unfunctional cells. Apoptosis is a programmed cell death obtaining this balance. ... -
Effects of combination of p-dimethylaminoazobenzene and dioxin on serum lipid profile
(2010)Objective: The liver cancer initiator p-dimethylaminoazobenzene and the potent liver promoter Dioxin are the environmental pollutants that people may be exposed to those in their daily lives. Butyrylcholinesterase is a ... -
Koyun Karaciğerinden Alkol Dehidrogenaz: Saflaştırma, Karakterizasyon, ve Bazı Antibiyotiklerin Etkileri
(2017)Alkol dehidrogenaz (ADH), her bir alt biriminin bir Zn2+ metal içeren katalitik alana ve bir kofaktör bağlama alanına sahip olduğu dimerik bir enzimdir. Bu enzim, alkolü, aldehide dönüştürür. Bu makale koyun karaciğerinden ... -
The effects of carvacrol on apoptosis of H-ras and N-ras transformed cell lines
(2011)Fenolik bir monoterpen olan karvakrol kekik bitkisinde bulunmaktadır ve besinlerde baharat olarak kullanılmaktadır. Bu çalışmanın amacı, karvakrol’ün H-ras transform edilmiş 5RP7 ve N-ras transform edilmiş CO25 hücreleri ... -
The effects of some phenanthroline ruthenium (II) complexes on a549 cell proliferation
(2013)Ruthenium (II) komplekslerinin DNA bağlanması He ilgili olan yüksek antitumor aktiviteleri nedeni He bu bileşikler son yıllarda araştırmacıların yoğun ilgisini çekmektedir. Bu çalismada imidazo[4,5-f][ 1,10]fenantrolin ...
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