Güncel Gönderiler: Makale Koleksiyonu
Toplam kayıt 86, listelenen: 21-40
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Apoptotic effects of some thiohydantoin derivatives [Bazi{dotless} Tiyohidantoin Türevlerinin Apoptotik Etkileri]
(2010)Objectives: The aim of this study is to investigate the effects of newly synthesized 3-phenly-and 3-(4-methoxyphenyl)-2-thiohydantoin derivatives on 5RP7 ve CO25 cell apoptosis. Methods and Materials: Thiohydantoin derivatives ... -
Determination of apoptosis on fibronectin and collagen iv adhered 5RP7 cells [Fi·bronekti·n ve kolajen iv'e bagli 5RP7 hücreleri·nde apoptozun beli·rlenmesi·]
(2009)Extracellular proteins such as fibronectin and collagen IV have a function in many cellular events such as cell growth, cell differentiation, tissue formation, cell adhesion, wound healing as well as have an important ... -
Synthesis of some 5-methoxy-3-[(benzazole-2-yl)thioacétylamino]-2,3 -dihydrobenzofuran derivatives and investigation of antihypertensive activities [Synthèse de quelques dérivés de méthoxy-5 [(benzazole-2-yl)thioacétylamino]-3 dihydro-2,3 benzofuranne et recherche d'activité antihypertensive]
(1996)In this study, some 5-methoxy-3-[(benzazole-2-yl)thioacetylamino]-2,3-dihydrobenzofuran derivatives were synthesized and their structures were elucidated by IR, NMR and microanalyses. The antihypertensive activities of the ... -
In vitro effects of ?-tocopherol and ascorbic acid on antioxidant characteristics of HDL [?-Tokoferol ve askorbik asitin HDL'nin antioksidan özelligi üzerine in vitro etkileri]
(2011)phospholipids in low density lipoproteins (LDL) and have a capacity on inhibition of oxidative modification. These antioxidant and antiinflammatory properties are as important as its cholesterol efflux function on inhibition ... -
HepG2 hücrelerinde Vinkristin sülfat/?-viniferin kombinasyonunun vinkristin sülfat ile karşılaştırıldığında artmış etkinliğinin vurgulanması
(2016)Amaç: Bu çalışma HepG2 hücre hattında geç apoptoz ve mitokondriyal yolakta ?-viniferin (?-VNF)'in etkisini incelemek için dizayn edildi. Bu amaç için, HepG2 hücre dizisinde anti-kanser ilaç olarak kullanılan vinkristin ... -
Protective role of melatonin and coenzyme Q(10) in ochratoxin a toxicity in rat liver and kidney
(Sage Publications Inc, 2007)Melatonin ( MEL) and coenzyme Q10 ( CoQ10) both display antioxidant and free radical scavenger properties. In the present study, the effect of MEL and CoQ10 on the oxidative stress and fibrosis induced by ochratoxin A ( ... -
Modification of intracellular free calcium in cultured F2408 embryo fibroblasts by 3-sub substituted-2-thiohydantoin derivatives
(Wiley, 2004)3-substituted-2-thiohydantoin derivatives were synthesized and their Structures elucidated by IR, H-1-NMR spectroscopy and elemental analysis. The cytotoxicity of the 2-thiohydantoin derivatives to rat embryo fibroblasts ... -
Chemical characterization and anticholinesterase effects of essential oils derived from Salvia species
(Taylor & Francis Inc, 2016)Inhibitory effect of Salvia species herbal preparations on acetylcholinesterase (AChE) and butylcholinesterase (BuChE) activitiy may contribute to regulation of cognitive performance and impaired cholinergic functions in ... -
Serum Thrombopoietin Levels and Its Relationship With Thrombocytopenia in Patients With Cirrhosis
(Kowsar Publ, 2014)Background: Patients with cirrhosis usually have thrombocytopenia in discrete levels. The mechanism of thrombocytopenia is thought as splenic sequestration and destruction of platelets, impaired bone marrow generation and ... -
The effect of metformin and exercise on serum lipids, nitric oxide synthase and liver nitric oxide levels in streptozotocin-nicotinamide induced diabetic rats
(Academic Journals, 2012)The objective of this study was to determine the effects of metformin treatment and exercise intervention on lipid metabolism, nitric oxide (NO), nitric oxide synthase (NOS) and glucose levels in streptozotocin-nicotinamide ... -
Synthesis and Biological Evaluation of Some New Hydrazone Derivatives Bearing Pyrimidine Ring as Analgesic and Anti-Inflammatory Agents
(Polskie Towarzystwo Farmaceutyczne, 2018)New hydrazone derivatives were synthesized from 4-chloro-2-(methylthio) pyrimidine-5-carbohydrazide. IR, 1H-NMR, 13C-NMR, mass spectral data and elemental analysis characterized synthesized compounds. All compounds were ... -
Effects of acetylsalicylate overdose on lipopolysaccharide-induced lung injury in rats: the role of the VEGF
(Turkish Biochem Soc, 2012)Aim: Vascular endothelial growth factor production is decreased depending on the alveolar epithelial cell damage. Acute over expression of vascular endothelial growth factor in lung tissue contributes to the formation ... -
Synthesis and Evaluation of a New Series of Thiazolyl-pyrazoline Derivatives as Cholinesterase Inhibitors
(Turkish Pharmacists Assoc, 2018)Objectives: In recent years, the design of anticholinesterase agents based on molecular hybridization of pharmacologically active scaffolds has attracted a great deal of interest in medicinal chemistry. For this purpose, ... -
Butrylcholinesterase Activity in Chronic Liver Disease Patients and Correlation with Child-Pugh Classification and MELD Scoring System
(Clin Lab Publ, 2015)Background: After 40 years since establishment of Child-Pugh staging, 14 years since establishment of MELD scoring system, and 25 years since establishment of King's College Criteria, there is still a search for more ... -
Effects of sildenafil citrate on survival in the posterior leg replantation model
(Derman Medical Publ, 2017)Aim: Sildenafil citrate is a phosphodiesterase (POE) enzyme inhibitor and a vasodilator agent Its angioprotective and angiogenetic effects are widely known. The aim of this study was to Investigate the effects of sildenafil ... -
Effect of alpha lipoic acid and silymarin on bladder outlet obstruction
(Spandidos Publ LTD, 2013)The aim of the present study was to determine whether the treatment of obstructed rat bladders with alpha lipoic acid (ALA) and silymarin reverses the biochemical and physiological responses to bladder outlet obstruction ... -
Synthesis, characterization of some transition-metal complexes of a new heptadentate N(5)S(2) Schiff-base ligand and the effects of these metal complexes on U2OS cells cytotoxicity and DNA cleavage activity
(Taylor & Francis LTD, 2008)Metal complexes of a heptadentate N(5)S(2) donor Schiff-base ligand were synthesized by the template reaction between 2,6-bis(2-aminothiophenoxymethyl)pyridine and 2,2 '-bipyridine-6,6'-dicarboxaldehyde in the presence of ... -
Effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome
(Springer London LTD, 2016)Background Elevated serum uric acid levels and increased arginase activity are risk factors for cardiovascular diseases (CVD). The aim of the present study was to investigate effects of serum uric acid levels on the arginase ... -
Direct and protective effects of single or combined addition of vincristine and epsilon-viniferin on human HepG2 cellular oxidative stress markers in vitro
(Springer, 2016)The objective of this study is to examine the direct effects of low doses and high doses of epsilon-viniferin, a substance known to be an antioxidant, and vincristine sulphate, a chemotherapeutic agent, alone and in ...
