New Adamantyl Chalcones: Synthesis, Antimicrobial and Anticancer Activities
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info:eu-repo/semantics/closedAccessDate
2017Author
Tabbi, AouatefTebbani, Dahmane
Caporale, Angelamaria
Saturnino, Carmela
Nabavi, S. F.
Giuseppe, Palma
Rastrelli, Luca
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Background: A new variety of adamantyl chalcones (2, 3a-o) were efficiently prepared by Claisen-Schmidt reaction of 4-adamantyl acetophenone 2 with a serie of aromatic aldehydes in good yields. Their structures were confirmed by spectroscopic data, and the relative configuration of 3d was confirmed by X-ray crystallography. All synthesized chalcones were tested against a panel of Gram-positive and Gram-negative bacteria and pathogenic fungus and displayed strong antibacterial activity against Enterococcus faecali 29212, Pseudomonas aeruginosa ATCC27853, Escherichia coli and interesting antifungal activity against Candida glabrata ATCC 90030. Result: The effect of these compounds was also tested in vitro as antitumor on Miapaca2 cells. Compounds also showed anticancer activity against human pancreas cancer cell MiaPaca2.