Güncel Gönderiler: PubMed İndeksli Yayınlar Koleksiyonu
Toplam kayıt 1498, listelenen: 921-940
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Synthesis and biological evaluation of some new mono Mannich bases with piperazines as possible anticancer agents and carbonic anhydrase inhibitors
(Academic Press Inc Elsevier Science, 2019)New mono Mannich bases, (2-(4-hydroxy-3-((4-substituephenylpiperazin-1-yl)methyl)benzylidene)-2,3-dihydro-1H-inden-1-one), were prepared to evaluate their cytotoxic/anticancer properties and also their inhibitory effects ... -
Antimicrobial activity and a SAR study of some novel benzimidazole derivatives bearing hydrazone moiety
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)In this study 12 novel benzimidazole compounds bearing hydrazone moiety were synthesized in order to investigate their possible antibacterial and antifungal activity. Structures of the synthesized compounds were elucidated ... -
Antimicrobial Activity of a New Series of Benzimidazole Derivatives
(Pharmaceutical Soc Korea, 2011)Due to antimicrobial importance of benzimidazoles and hydrazones, some benzimidazole-hydrazone compounds were synthesized to screen their antimicrobial activity. Structures of the synthesized compounds were elucidated by ... -
Antimicrobial Activity of a New Combination System of Benzimidazole and Various Azoles
(Wiley-Blackwell, 2011)In the present study a new series of benzimidazole derivatives bearing various (benz)azolylthio moieties were synthesized so as to investigate their antimicrobial activity. Structures of the target compounds (5a-5i) were ... -
Antiproliferative effects of some N-benzylideneanilines
(John Wiley & Sons LTD, 2008)A series of Schiff bases including N-benzylideneaniline (NBA) nuclei were prepared. The chemical products obtained were characterized by mass spectometry (APCI), H-1 NMR, and IR spectroscopy in order to seek their cytotoxic ... -
Synthesis of 2-substituted-N-[4-(1-methyl-4,5-diphenyl-1H-imidazole-2-yl) phenyl]acetamide derivatives and evaluation of their anticancer activity
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)In the present study 18 novel imidazole-(benz)azole and imidazole-piperazine derivatives were synthesized in order to investigate their probable anticancer activity. The structures of the compounds were confirmed by IR, ... -
Studies on hydrazone derivatives as antifungal agents
(Taylor & Francis LTD, 2008)The increasing clinical importance of drug-resistant fungal pathogens has urged additional need to fungal research and new antifungal compound development. For this purpose, some N-(1-benzyl-2-phenylethylidene)-N'-[4-(ar ... -
Preparation of some pyrazoline derivatives and evaluation of their antifungal activities
(Informa Healthcare, 2010)The synthesis of a new series of 1-[( benzazole-2-yl)thioacetyl]-3,5-diaryl-2-pyrazoline derivatives was obtained by reacting 1-( chloroacetyl)-3,5-diaryl-pyrazolines with 2-mercaptobenzimidazole/benzoxazole/benzothiazole. ... -
Synthesis and the selective antifungal activity of 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine derivatives
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)Even though there are new classes of compounds now frequently used in treatment of fungal infections, the density of deeply invasive candidiasis has increased at least 10-fold during the past decade. Furthermore, many ... -
Design, Synthesis, and Neuroprotective Effects of a Series of Pyrazolines against 6-Hydroxydopamine-Induced Oxidative Stress
(MDPI, 2018)Parkinson's disease (PD) is a chronic, progressive, and age-related neurodegenerative disorder characterized by the loss of midbrain dopaminergic neurons caused by the accumulation of free radicals and oxidative stress. ... -
Synthesis and Evaluation of New Oxadiazole, Thiadiazole, and Triazole Derivatives as Potential Anticancer Agents Targeting MMP-9
(MDPI, 2017)Matrix metalloproteinases (MMPs) are important proteases involved in tumor progression including angiogenesis, tissue invasion, and migration. Therefore, MMPs have been reported as potential diagnostic and prognostic ... -
Synthesis and Evaluation of a New Series of Arylidene Indanones as Potential Anticancer Agents
(Bentham Science Publ LTD, 2018)Background: Arylidene indanones have attracted a great deal of interest due to their outstanding therapeutic applications. In particular, considerable research has pointed out the importance of arylidene indanones in the ... -
A New Series of Pyrrole-Based Chalcones: Synthesis and Evaluation of Antimicrobial Activity, Cytotoxicity, and Genotoxicity
(MDPI AG, 2017)In an effort to develop new potent antimicrobial and anticancer agents, new pyrrole-based chalcones were designed and synthesized via the base-catalyzed Claisen-Schmidt condensation of 2-acetyl-1-methylpyrrole with ... -
Synthesis and evaluation of new indole-based chalcones as potential antiinflammatory agents
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2015)In the present work, new indole-based chalcone derivatives were obtained via the reaction of 5-substituted-1H-indole-3-carboxaldehydes/1-methylindole-3-carboxaldehyde with appropriate acetophenones. The synthesized compounds ... -
Synthesis of 1-acetyl-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives and evaluation of their anticancer activity
(Informa Healthcare, 2013)In the present study, 1-acetyl-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives (1-6) were synthesized via the ring closure reaction of 1-(2-thienyl)-3-aryl-2-propen-1-ones with hydrazine hydrate in acetic acid. The chemical ... -
Synthesis and Evaluation of New 1,5-Diaryl-3-[4-(methyl-sulfonyl)phenyl]-4,5-dihydro-1H-pyrazole Derivatives as Potential Antidepressant Agents
(MDPI, 2015)In an effort to develop potent antidepressant agents, new pyrazoline derivatives 2a-s were synthesized and evaluated for their antidepressant-like activity by tail suspension test (TST) and modified forced swimming test ... -
Synthesis and Biological Evaluation of Pyrazoline Derivatives Bearing an Indole Moiety as New Antimicrobial Agents
(Wiley-V C H Verlag GMBH, 2013)1-(p-Methylphenyl)-3,5-diaryl-2-pyrazoline derivatives (2a-f) were synthesized via the treatment of 1-(1H-indol-3-yl)-3-aryl-2-propen-1-ones (1a-f) with p-methylphenylhydrazine hydrochloride in hot acetic acid. The structures ... -
Synthesis and AChE Inhibitory Activity of Novel Thiazolylhydrazone Derivatives
(MDPI, 2019)Alzheimer's disease (AD) is the most common of the degenerative brain diseases and is described together with the impairment of cognitive function. Patients with AD lose the capability to code new memories, and life ... -
Synthesis and Anticandidal Activity of New Imidazole-Chalcones
(MDPI, 2018)In the present work, 15 new 1-(4-(1H-imidazol-1-yl)phenyl)-3-(4-substituedphenyl) prop-2-en-1-one derivatives (3a-3o) were synthesized to evaluate their antifungal activity. Structures of newly synthesized imidazole ... -
Synthesis and biological activities of new hydrazide derivatives
(Taylor & Francis LTD, 2009)The synthesis of a new series of imidazo[1,2-a]pyrazine-2-carboxylic acid arylidene-hydrazides is described. The chemical structures of the compounds were elucidated by IR, H-1-NMR, FAB(+)-MS spectral data. Their biological ...
