Preparation of some pyrazoline derivatives and evaluation of their antifungal activities
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info:eu-repo/semantics/openAccessTarih
2010Yazar
Özdemir, AhmetTuran, Gülhan
Kaplancıklı, Zafer Asım
Revıal, Gilbert
Demirci, Fatih
İşcan, Gökalp
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The synthesis of a new series of 1-[( benzazole-2-yl)thioacetyl]-3,5-diaryl-2-pyrazoline derivatives was obtained by reacting 1-( chloroacetyl)-3,5-diaryl-pyrazolines with 2-mercaptobenzimidazole/benzoxazole/benzothiazole. The chemical structures of the compounds were elucidated by (1)H-NMR, (13)C-NMR, and FAB(+)-MS spectral data. Their antifungal activities against Candida albicans, Candida glabrata, Candida utilis, Candida tropicalis, Candida krusei, and Candida parapsilosis were investigated. A significant level of activity was observed.