| dc.contributor.author | Yenilmez, Evrim | |
| dc.contributor.author | Başaran, E. | |
| dc.contributor.author | Arslan, Rana | |
| dc.contributor.author | Berkman, Murat Sami | |
| dc.contributor.author | Güven, Umay Merve | |
| dc.contributor.author | Baycu, C. | |
| dc.contributor.author | Yazan, Yasemin | |
| dc.date.accessioned | 2019-10-19T16:02:39Z | |
| dc.date.available | 2019-10-19T16:02:39Z | |
| dc.date.issued | 2015 | |
| dc.identifier.issn | 0031-7144 | |
| dc.identifier.uri | https://dx.doi.org/10.1691/ph.2015.4126 | |
| dc.identifier.uri | https://hdl.handle.net/11421/13858 | |
| dc.description | WOS: 000349054200001 | en_US |
| dc.description | PubMed ID: 25997244 | en_US |
| dc.description.abstract | In the present study chitosan based gel formulations containing Egg Yolk Oil (EYO) and Epidermal Growth Factor (EGF) were formulated successfully aiming at enhanced topical treatment of dermal burns the combination of traditional approaches with modern drug delivery systems. Physicochemical properties of the formulations were analyzed and efficacy of the formulations prepared were evaluated versus a commercial product; Silverdin (R) (1% silver sulfadiazine) in vivo on Wistar rats. Burns were generated on the back of the rats and at predetermined time intervals tissue samples were collected and evaluated histologically. The analyses showed that chitosan based gel formulations containing Egg Yolk Oil (El) and chitosan based gel formulations containing EYO and EGF (M1) formulations seem to be better alternatives for Silverdin (R) with a significant difference (p<0.05) considering healing ranks of tissue samples. | en_US |
| dc.description.sponsorship | Anadolu University Scientific Research Project Foundation [090343] | en_US |
| dc.description.sponsorship | We show our appreciation to the Department of Histology-Embriyology, Osmangazi University School of Medicine. We also thank Dr. Erhan Sahin for evaluation statistical analysis and Huri Cinar for technical assistance. This study was financed by Anadolu University Scientific Research Project Foundation (Project No:090343). The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Govi-Verlag Pharmazeutischer Verlag GMBH | en_US |
| dc.relation.isversionof | 10.1691/ph.2015.4126 | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.title | Chitosan gel formulations containing egg yolk oil and epidermal growth factor for dermal burn treatment | en_US |
| dc.type | article | en_US |
| dc.relation.journal | Pharmazie | en_US |
| dc.contributor.department | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı | en_US |
| dc.identifier.volume | 70 | en_US |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.startpage | 67 | en_US |
| dc.identifier.endpage | 73 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US] |
| dc.contributor.institutionauthor | Arslan, Rana | |
| dc.contributor.institutionauthor | Berkman, Murat Sami | |
| dc.contributor.institutionauthor | Yazan, Yasemin | |
