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dc.contributor.authorÖztürk, Ahmet Alper
dc.contributor.authorYenilmez, Evrim
dc.contributor.authorArslan, Rana
dc.contributor.authorŞenel, Behiye
dc.contributor.authorYazan, Yasemin
dc.date.accessioned2019-10-19T16:02:39Z
dc.date.available2019-10-19T16:02:39Z
dc.date.issued2017
dc.identifier.issn0326-2383
dc.identifier.urihttps://hdl.handle.net/11421/13851
dc.descriptionWOS: 000418362900004en_US
dc.description.abstractDevelopment and in vivo/in vitro evaluation of dexketoprofen trometamol (DT)-loaded nanosized, controlled release drug delivery system was aimed in this study.. DT-loaded Kollidon (R) SR (KSR) and Eudragit (R) RS 100 (ERS) polymeric nanoparticles were prepared using Nano Spray-Dryer (B-90, Buchi Labortechnik AG, Flawil, Switzerland). Both delivery systems prepared were characterized for selecting optimum formulations to investigate DT release profiles/kinetics, cytotoxicities and in vivo behaviors on animals. Structures of KSR and ERS were characterized by particle size and zeta potential measurements, shape and surface imaging, thermal analysis, X-ray diffraction, FTIR and H-1-NMR determinations. DT-loaded particles demonstrated nanostructured and spherical shape while in vitro relase studies showed extended release of DT incorporated. Korsmeyer-Peppas kinetic model was found to fit the best using DDSolver software program. Optimum formulations selected also showed prolonged analgesic activity in mice. Depending on in vitro and in vivo test results, formulations developed in this study seem to prolong release of DT from the nanoparticles prepared and are promising for extending analgesic activity.en_US
dc.description.sponsorshipAnadolu University Scientific Research Project Foundation [1502S081]en_US
dc.description.sponsorshipThis study was financed by Anadolu University Scientific Research Project Foundation (No: 1502S081). The authors would like to thank Abdi Ibrahim (Istanbul, Turkey) for providing a gift sample of DT. Faculty of Engineering is acknowledged for XRD, Faculty of Science for SEM, DOPNALAB Faculty of Pharmacy for FTIR and AUBIBAM for <SUP>1</SUP>H-NMR analysis facilities.en_US
dc.language.isoengen_US
dc.publisherColegio Farmaceuticos Provincia De Buenos Airesen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDexketoprofen Trometamolen_US
dc.subjectKollidon (R) Sren_US
dc.subjectEudragit (R) Rs 100en_US
dc.subjectPolmeric Nanoparticleen_US
dc.subjectProlonged Releaseen_US
dc.titleDexketoprofen Trometamol-Loaded Kollidon (R) SR and Eudragit (R) RS 100 Polymeric Nanoparticles: Formulation and In Vitro-In Vivo Evaluationen_US
dc.typearticleen_US
dc.relation.journalLatin American Journal of Pharmacyen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalıen_US
dc.identifier.volume36en_US
dc.identifier.issue11en_US
dc.identifier.startpage2153en_US
dc.identifier.endpage2165en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.contributor.institutionauthorArslan, Rana
dc.contributor.institutionauthorŞenel, Behiye
dc.contributor.institutionauthorYazan, Yasemin


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