dc.contributor.author | Başaran, Ebru | |
dc.contributor.author | Demirel, Müzeyyen | |
dc.contributor.author | Sırmagül, Başar | |
dc.contributor.author | Yazan, Yasemin | |
dc.date.accessioned | 2019-10-19T16:02:36Z | |
dc.date.available | 2019-10-19T16:02:36Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 0265-2048 | |
dc.identifier.issn | 1464-5246 | |
dc.identifier.uri | https://dx.doi.org/10.3109/02652040902846883 | |
dc.identifier.uri | https://hdl.handle.net/11421/13830 | |
dc.description | WOS: 000275310000005 | en_US |
dc.description | PubMed ID: 19545226 | en_US |
dc.description.abstract | In the present study, Cyclosporine A (CsA) was successfully incorporated into cationic solid lipid nanoparticles (SLN) for ocular application. Physicochemical characterizations of SLNs were analysed in detail during the storage period of 6 months. Due to the better characteristics like smaller particle size (248.00 +/- 0.33 nm) with narrow size distribution (PI = 0.25 +/- 0.00), high zeta potential (50.30 +/- 0.78 mV) and more stable lipid structure, Dynasan (R) 116 structured FD4 (0.1% CsA) formulation was chosen for in vivo studies. Sheep were used in in vivo studies and 200 mu L of formulation was applied to sheep' eyes (n = 6) under veterinarian supervision. Samples were collected at pre-determined time intervals and were analysed by enzyme immune assay (EIA). CsA could be detected in both aqueous and vitreous humour samples for 48 h showing the ocular penetration of formulation. Release profiles were not decreased during 48 h indicating controlled and prolonged release of active agent from positively charged SLN formulations due to increased residence time in eyes. Similarities in CsA concentration data showed that inter-individual variance did not influence the ocular penetration of CsA when formulated as SLN. | en_US |
dc.description.sponsorship | Anadolu University Scientific Research Project Foundation [040342]; Nagai Foundation (Tokyo) [FAPA-2008] | en_US |
dc.description.sponsorship | The authors would like to thank Professor Dr Nilgun Yildirim and Professor Dr Hikmet Basmak for their advise and to Mehmet Dincer (veterinarian) for professional assistance in the in vivo studies. Dr Yavuz Akbulut is acknowledged for statistical analyses and BIBAM management for FT-IR and <SUP>1</SUP>H-NMR analyses facilities. This study was financed by Anadolu University Scientific Research Project Foundation (No: 040342) and also was awarded by The Nagai Foundation (Tokyo) as the best research work in FAPA-2008 in Singapore. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis LTD | en_US |
dc.relation.isversionof | 10.3109/02652040902846883 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Cyclosporine A | en_US |
dc.subject | Cationic Solid Lipid Nanoparticles | en_US |
dc.subject | Ocular Application | en_US |
dc.title | Cyclosporine-A incorporated cationic solid lipid nanoparticles for ocular delivery | en_US |
dc.type | article | en_US |
dc.relation.journal | Journal of Microencapsulation | en_US |
dc.contributor.department | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı | en_US |
dc.identifier.volume | 27 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 37 | en_US |
dc.identifier.endpage | 47 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US] |
dc.contributor.institutionauthor | Demirel, Müzeyyen | |
dc.contributor.institutionauthor | Yazan, Yasemin | |