Kurum Yazarı "Demirel, Müzeyyen" Makale Koleksiyonu İçin Listeleme
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Cyclosporine-A incorporated cationic solid lipid nanoparticles for ocular delivery
Başaran, Ebru; Demirel, Müzeyyen; Sırmagül, Başar; Yazan, Yasemin (Taylor & Francis LTD, 2010)In the present study, Cyclosporine A (CsA) was successfully incorporated into cationic solid lipid nanoparticles (SLN) for ocular application. Physicochemical characterizations of SLNs were analysed in detail during the ... -
Enhanced bioavailability of cinnarizine using solid dispersion: In vitro and in vivo evaluation
Demirel, Müzeyyen; Büyükköroğlu, G.; Sırmagül, Başar; Kalava, B. S.; Öztürk, Nilgün; Yazan, Yasemin (Bentham Science Publishers B.V., 2015)The aim of this study was to modify the release and thus enhance the bioavailability of acalcium antagonist cinnarizine whose aqueouse solubility is low and half-life is short. For this purpose, solid dispersion system was ... -
Enhancement in dissolution pattern of piribedil by molecular encapsulation with beta-cyclodextrin
Demirel, Müzeyyen; Büyükköroğlu, G; Kalava, BS; Yazan, Yasemin (Prous Science, Sa, 2006)The aim of this was to improve the dissolution behavior of piribedil by molecular encapsulation with beta-cyclodextrin (beta-CD). Toward this aim, physical mixing, co-grinding, and spray-drying methods were used to prepare ... -
Formulation and in vitro-in vivo evaluation of piribedil solid lipid micro- and nanoparticles
Demirel, Müzeyyen; Yazan, Yasemin; Muller, RH; Kılıç, F; Bozan, B (Taylor & Francis LTD, 2001)Modification of the dissolution rate and, thus, the enhancement of the bioavailability of a dopaminergic drug, piribedil, which has a low aqueous solubility and short elimination half-life have been the aim in this study. ... -
Microencapsulation of ketorolac tromethamine by means of a coacervation phase separation technique induced by the addition of non-solvent
Genç, Lütfi; Demirel, Müzeyyen; Güler, E; Hegazy, N (Taylor & Francis LTD, 1998)Ketorolac tromethamine (KT) is a non-steroidal drug with potent analgesic and anti-inflammatory activity and is absorbed rapidly (T-max (1.0h) with an efficiency >87% following oral and intramuscular administration. The ... -
Physicochemical characterization and dissolution properties of cinnarizine solid dispersions
Sudaki çözünürlüğü düşük olarak bilinen kalsiyum antagonisti sinnarizinin biyoyararlanımı değişken veya düşüktür. Bu özellikteki bir ilaç materyalinin çözünme davranışının iyileştirilmesi, oral biyoyararlanımı geliştirebilir. ... -
Polymeric Cyclosporine-A Nanoparticles for Ocular Application
Başaran, Ebru; Demirel, Müzeyyen; Sırmagül, Başar; Yazan, Yasemin (Amer Scientific Publishers, 2011)In the present study, cyclosporine A (CsA) was incorporated successfully into cationic Eudragit(R) RS 100 nanoparticles (EPNs) aiming ocular application. Physicochemical characterization of the EPNs prepared was performed ... -
Preparation of prolonged release clarithromycin microparticles for oral use and their in vitro evaluation
Genç, Lütfi; Demirel, Müzeyyen; Yazan, Yasemin (Pharmaceutical Soc Korea, 2006)Prolonged release microparticles of clarithromycin (CL) were prepared using Eudragit RL 100 and RS 100 by spray-drying and casting-drying techniques. For the characterization of those microparticles, preparation yield, ... -
Propranolol HCl imprinted polymeric microspheres: Development, characterization and dissolution
Specificity to target molecule, high selectivity and sensitivity to release and targeting were achieved using molecularly imprinted polymer (MIP) systems. In this study, propranolol HCl (PHCL) imprinted methacryloylamido ... -
Studies on Polymeric and Lipid Nanoparticles of Ketoconazole for Ocular Administration
Demirel, Müzeyyen; Genç, Lütfi (Colegio Farmaceuticos Provincia De Buenos Aires, 2015)The fungistatic molecule ketoconazole was incorporated into polymeric (Eudragit (R) RS 100) and solid lipid (Gelucire (R) 44/14) nanoparticles by quasi-emulsion solvent evaporation technique aiming ocular application. ... -
Studies on rosuvastatin calcium incorporated chitosan salt nanoparticles
Al-Heibshy, Fawaz N. S.; Başaran, Ebru; Demirel, Müzeyyen (Colegio de Farmaceuticos de la Provincia de Buenos Aires, 2016)Cardiovascular diseases are the leading causes of death worldwide and rosuvastatin calcium (RCa) is one of the most effective drugs used for the prevention of coronary heart diseases. Considering low aqueous solubility ...