Güncel Gönderiler: Farmasötik Kimya Anabilim Dalı
Toplam kayıt 345, listelenen: 21-40
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Synthesis and evaluation of new pyrazoline-thiazole derivatives as monoamine oxidase inhibitors
(HeteroCorporation, 2019)A novel series of 1,3,5-trisubstituted-2-pyrazoline derivatives (4a-4k) was synthesized and their chemical structures characterized by 1H NMR, 13C NMR, and mass spectroscopy. These compounds were evaluated as inhibitors ... -
Synthesis and antimicrobial activity evaluation of new hydrazide derivatives [Yeni Hidrazid Türevlerinin Sentezi ve Bunlari{dotless}n Antimikrobiyal Aktivitelerinin Degerlendirilmesi]
(2011)The enhancement of bacterial resistance of pathogens to currently available antibiotics constitutes a serious public health threat. Therefore, intensive efforts are underway worldwide to develop new antimicrobial agents. ... -
Synthesis of some 4-phenyl/cyclohexyl-5-(l-phenoxyethyl)-3-[(3,5- diaryl-2-pyrazolinyl)acetyl]thio-4h-l,2,4-triazole derivatives and their antifungal activity [Bazi{dotless} 4-fenil/siklohegzil-5-(1-fenoksietil)-3-[(3,5-diaril-2-pirazolinil)aseti l]tiyo-4h-1,2,4-triazol türevlerinin sentezleri ve antifungal etkileri]
(2011)Triazole derivatives are the major chemical group of antifungal azole derivatives. Nowadays, the most frequently used triazoles are fluconazole and itraconazole. They posses a broad spectrum of antifungal activity and ... -
Synthesis and anticancer activity of some bisquinoxaline derivatives [Bazi biskinoksalin türevlerinin sentezleri ve antikanser aktiviteleri]
(2011)Resistance improvement against the existing anticancer agents creates a research area for new anticancer agents. Nevertheless, it is rather difficult to develop a new agent which can selectively inhibit the proliferation ... -
A mini-survey on vitamin usage habits in eskİşehİr [Eskişehir'de vitamin kullamm ahskanhklari{dotless} üzerine dar kapsamh bir araşti{dotless}rma]
(2013)In the present study, vitamin usage habits of five hundred people representing four different socio-cultural groups in Eskişehir and the factors affecting these habits were studied. The participants of the research were ... -
Synthesis and biological activity of derivatives of 4-benzylpiperazine-1-dithiocarbamates
(Azerbaijan Medical University, 2014)Derivatives of 4-benzylpiperazine-l-dithiocarbamate were synthesized and their structures were identified by elemental analysis, IR-, NMR- and MS-spectroscopy. The biological activity of synthesized derivatives of ... -
Antifungal effects of some oxadiazole derivatives on pathogenic molds [Bazi{dotless} oksadiazol türevlerinin patojenik küfler üzerindeki antifungal etkileri]
(2013)Some oxadiazole derivatives were tested in vitro against Aspergillus parasiticus, Aspergillus flavus, Aspergillus niger, Fusarium solani, Fusarium moniliforme and Stachybotrys chartarum. All compounds showed the highest ... -
Synthesis and antimicrobial activity of some pyrazoline derivatives bearing amide moiety [Amit parçasi{dotless} taşi{dotless}yan bazi{dotless} pirazolin türevlerinin sentezi ve antimikrobiyal etkileri]
(2013)In the present study, a series of pyrazoline derivatives were synthesized. The chemical structures of the compounds were elucidated by IR, 1H-NMR, 13C-NMR and FAB+- MS spectral data and elemental analyses. The synthesized ... -
Synthesis of some novel Carbazole derivatives and evaluation of their antimicrobial activity [Bazi{dotless} yeni karbazol türevlerinin sentezleri ve antimikrobiyal aktivitelerinin araşti{dotless}li{dotless}lmasi{dotless}]
(2011)Carbazole and its derivatives are an important type of nitrogen containing aromatic heterocyclic compounds which have attracted considerable attention of medicinal chemists due to their antimicrobial activities. For this ... -
Antimicrobial activity evaluation of new 1,3,4-oxadiazole derivatives
(University of Istanbul, 2017)In this study, we have synthesized seven novel 2-[(5-(4-chlorobenzyl)-1,3,4-oxadiazol-2-yl)thio]-N-(6-substituted benzothiazol-2-yl)acetamide derivatives (4ag) starting from ethyl 4-chlorophenyl acetate. The antimicrobial ... -
Synthesis and antimycobacterial activity evaluation of isatin-derived 3- [(4-aryl-2-thiazolyl])hydrazone]-1H-indol-2,3-diones
(University of Istanbul, 2017)A series of 3-[(4-aryl-2-thiazolyl)hydrazone]-1H-indol-2,3-dione derivatives (2a-f) were designed and synthesized using isatin as starting material. The obtained thiazole compounds were screened to investigate their ... -
Novel benzothiazole based imidazole derivatives as new cytotoxic agents against glioma (C6) and liver (HepG2) cancer cell lines
(University of Istanbul, 2017)In this work, some novel N-(6-substituted-benzothiazol-2-yl)-2-[[4,5-dimethyl-1-((p-tolyl/4-nitrophenyl)amino)-1H-imidazol-2-yl]thio]acetamide derivatives were synthesized and searched for their cytotoxic activities against ... -
Synthesis of novel 3, 5, 6-trisubstituted triazine derivatives and their biological activity evaluation as potential antitumor and anti-inflammatory agents
(University of Istanbul, 2016)In this study, new 3, 5, 6-trisubstituted 1, 2, 4-triazine derivatives (1-9) were synthesized and their structures were determined by using NMR, IR and Mass spectroscopic methods. In vitro antitumor activities against MCF-7 ... -
Synthesis and antimicrobial activity evaluation of novel nitrofuranthiazoles
(University of Istanbul, 2016)In this work, six novel 4-aryl-2-[2-((5-nitrofuran-2-yl)methylene)hydrazinyl] thiazole derivatives (2a-f) were synthesized starting from 5-nitro-2-furaldehyde diacetate by using Hantzsch thiazole synthesis. The antimicrobial ... -
Synthesis and biological screening of some novel triazole derivatives
(Turkish Pharmacists Association, 2015)In the present study 15 novel triazole compounds were synthesized in order to investigate their anticandidal and anticholinesterase activities. Structures of the synthesized compounds were elucidated by spectral data and ... -
Synthesis and characterization of new binaphthyl-linked phenanthroline-, bipyridine-, or pyridine-derived ligands, and the study of their cytotoxic activity
(2008)In the present work, we describe the synthesis and characterization of five new versatile acyclic or macrocyclic ligands containing binaphthyl-linked pyridine, bipyridine, or phenanthroline groups in their framework (see ... -
Synthesis of some hydrazone derivatives bearing purine moiety as anticancer agents [Antikanser ajanlar olarak pürin parçasi{dotless} taşi{dotless}yan bazi{dotless} hidrazon türevlerinin sentezi]
(Turkish Pharmacists Association, 2014)In the present study, some hydrazone derivatives were synthesized via the reaction of 6-hydrazino-9-(ß-D-ribofuranosyl)-9H-purine with various benzaldehydes. The structures of the compounds were elucidated by spectroscopic ... -
Studies on some new pyrazolo[3,4-c]pyridine derivatives as antimicrobial agents [Antimikrobiyal ajan olarak bazi yeni pirazolo[3,4-c]piridin türevleri üzerine çahsmalar]
(2009)The increasing clinical importance of drug-resistant bacterial and fungal pathogens has lent additional urgency to microbiological research and novel antimicrobial compounds development. For this aim, a series of N-[(Benzhydryl) ... -
Benzimidazol derivatives: Synthesis, antibacterial activity and QSARs of some 2-alkyl-5-chloro-benzimidazoles
(1989)[No abstract available] -
Studies on thiazolyliminothiazoline derivatives as potential antitubercular agents
(2009)In this study, eight new ethyl {2-[3,4-diaryl-3H-thiazol-2-ylidenamino] thiazol-4-yl}acetate were synthesized by reacting ethyl [2-(3-aryl(thiouredio) thiazol-4-yl]acetate and phenacyl bromides in ethanol. The solid was ...