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dc.contributor.authorAslan, Hatice Esra
dc.contributor.authorDemir, Y.
dc.contributor.authorÖzaslan, Muhammet Serhat
dc.contributor.authorTürkan, F.
dc.contributor.authorBeydemir, Ş.
dc.contributor.authorKüfrevioğlu, Ö. I.
dc.date.accessioned2019-10-19T14:03:13Z
dc.date.available2019-10-19T14:03:13Z
dc.date.issued2019
dc.identifier.issn0148-0545
dc.identifier.urihttps://dx.doi.org/10.1080/01480545.2018.1463242
dc.identifier.urihttps://hdl.handle.net/11421/12539
dc.description.abstractCarbonic anhydrase (CA) has a key role in respiration, carbon dioxide and bicarbonate transport. Acetylcholinesterase (AChE) is a serine hydrolase and mostly abundant at neuromuscular junctions and cholinergic brain synapses. Inhibitors of these enzymes could aid in illuminating the role in disease processes. In this study, we separately purified CA I and CA II from human erythrocytes. The purity of the enzymes was showed by SDS-PAGE analysis. We also investigated the inhibition of seven chalcones toward hCA I, hCA II, and AChE. The chalcones were effective inhibitors of the cytosolic CA isoforms (hCA I and hCA II) and AChE with Ki values in the range of 1.83–7.05 µM for hCA I, 0.59–5.50 µM for hCA II, and 0.61–86.11 µM for AChE. All compounds were showed competitive inhibition aganist both enzymes. These compounds can be a potent inhibitor of AChE enzyme and both cytosolic CA isoenzymes which are commonly used in the pharmaceutical and medical industriesen_US
dc.language.isoengen_US
dc.publisherTaylor and Francis Ltden_US
dc.relation.isversionof10.1080/01480545.2018.1463242en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectCarbonic Anhydraseen_US
dc.subjectChalconeen_US
dc.subjectInhibitionen_US
dc.subjectPurificationen_US
dc.titleThe behavior of some chalcones on acetylcholinesterase and carbonic anhydrase activityen_US
dc.typearticleen_US
dc.relation.journalDrug and Chemical Toxicologyen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Biyokimya Anabilim Dalıen_US
dc.identifier.volume42en_US
dc.identifier.issue6en_US
dc.identifier.startpage634en_US
dc.identifier.endpage640en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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