Gelişmiş Arama

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dc.contributor.authorDemir, Yeliz
dc.contributor.authorTaslimi, Parham
dc.contributor.authorÖzaslan, Muhammet Serhat
dc.contributor.authorÖztaşkın, Necla
dc.contributor.authorÇetinkaya, Yasin
dc.contributor.authorGülçin, İlhami
dc.contributor.authorGöksu, Süleyman
dc.date.accessioned2019-10-19T14:02:56Z
dc.date.available2019-10-19T14:02:56Z
dc.date.issued2018
dc.identifier.issn0365-6233
dc.identifier.issn1521-4184
dc.identifier.urihttps://dx.doi.org/10.1002/ardp.201800263
dc.identifier.urihttps://hdl.handle.net/11421/12449
dc.descriptionWOS: 000451876200002en_US
dc.descriptionPubMed ID: 30478943en_US
dc.description.abstractAldose reductase converts glucose to sorbitol in the polyol pathway. It is an important enzyme to prevent diabetic complications. In this study, we studied the inhibitory effects of bromophenol derivatives on aldose reductase (AR), alpha-glucosidase, and alpha-amylase enzymes. In the bromophenols series, compound 1f showed the maximum inhibition effect against AR with a K-i value of 0.05 +/- 0.01 mu M, while compound 1d showed the lowest inhibition effect against AR with a K-i value of 1.13 +/- 0.99 mu M. In addition, alpha-amylase from porcine pancreas and alpha-glucosidase from Saccharomyces cerevisiae were used as enzymes. In this study, all compounds were tested for the inhibition of the alpha-glucosidase enzyme and demonstrated efficient inhibition profiles with K-i values in the range of 43.62 +/- 5.28 to 144.37 +/- 16.37 nM against alpha-glucosidase. Additionally, these compounds were tested against the alpha-amylase enzyme, which determined an effective inhibition profile with IC50 values in the range of 9.63-91.47 nM. These compounds can be selective inhibitors of AR, alpha-glucosidase, and alpha-amylase enzymes as antidiabetic agents.en_US
dc.language.isoengen_US
dc.publisherWiley-V C H Verlag GMBHen_US
dc.relation.isversionof10.1002/ardp.201800263en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlpha-Amylaseen_US
dc.subjectAlpha-Glucosidaseen_US
dc.subjectAldose Reductaseen_US
dc.subjectBromophenolen_US
dc.subjectEnzyme Inhibitionen_US
dc.titleAntidiabetic potential: In vitro inhibition effects of bromophenol and diarylmethanones derivatives on metabolic enzymesen_US
dc.typearticleen_US
dc.relation.journalArchiv Der Pharmazieen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Biyokimya Anabilim Dalıen_US
dc.identifier.volume351en_US
dc.identifier.issue12en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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