Yazar "Temel, Halide Edip" için Makale Koleksiyonu listeleme
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Apoptotic effects of some carbazole derivatives on lung carcinoma and glioma cell lines
Çiftçi, Gülsen Akalın; Temel, Halide Edip; Yıldırım, Şafak Ulusoylar; Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Genç, Lütfi (Springer Birkhauser, 2013)In this study, we aimed to study the apoptotic effects of 2-[(9-ethyl-9H-carbazol-3-yl)amino]-2-oxoethyl N,N-disubstituted dithiocarbamates on A549 lung carcinoma and C6 glioma cell lines. Cytotoxicity analyses of DNA ... -
Butrylcholinesterase Activity in Chronic Liver Disease Patients and Correlation with Child-Pugh Classification and MELD Scoring System
Temel, Halide Edip; Temel, Tuncer; Cansu, Dondu Üsküdar; Özakyol, Ayşegül (Clin Lab Publ, 2015)Background: After 40 years since establishment of Child-Pugh staging, 14 years since establishment of MELD scoring system, and 25 years since establishment of King's College Criteria, there is still a search for more ... -
Chemical characterization and anticholinesterase effects of essential oils derived from Salvia species
Temel, Halide Edip; Demirci, Betül; Demirci, Fatih; Celep, Ferhat; Kahraman, Ahmet; Doğan, Musa; Başer, K. Hüsnü Can (Taylor & Francis Inc, 2016)Inhibitory effect of Salvia species herbal preparations on acetylcholinesterase (AChE) and butylcholinesterase (BuChE) activitiy may contribute to regulation of cognitive performance and impaired cholinergic functions in ... -
Cytotoxic, Apoptotic and DNA Synthesis Inhibitory Effects of Some Thiazole Derivatives
Çiftçi, Gülsen Akalın; Altıntop, Mehlika Dilek; Temel, Halide Edip; Özdemir, Ahmet; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2017)Background: Cancer is one of the leading causes of morbidity and mortality worldwide and extensive efforts have been devoted to the discovery of new anticancer agents. In the last few decades, the clinical efficacy of ... -
Effect of alpha lipoic acid and silymarin on bladder outlet obstruction
Yıldırım, Abidin; Başesikoğlu, Barbaros; Temel, Halide Edip; Erkasap, Nilüfer; Yenilmez, Aydın; Uslu, Sema; Dönmez, Turgut (Spandidos Publ LTD, 2013)The aim of the present study was to determine whether the treatment of obstructed rat bladders with alpha lipoic acid (ALA) and silymarin reverses the biochemical and physiological responses to bladder outlet obstruction ... -
The effect of metformin and exercise on serum lipids, nitric oxide synthase and liver nitric oxide levels in streptozotocin-nicotinamide induced diabetic rats
Akyüz, Fahrettin; Tekin, Neslihan; Aydın, Özlem; Temel, Halide Edip; Işıklı, Burhanettin (Academic Journals, 2012)The objective of this study was to determine the effects of metformin treatment and exercise intervention on lipid metabolism, nitric oxide (NO), nitric oxide synthase (NOS) and glucose levels in streptozotocin-nicotinamide ... -
Effects of acetylsalicylate overdose on lipopolysaccharide-induced lung injury in rats: the role of the VEGF
Akyüz, Fahrettin; Aydın, Özlem; Aydın, Tayfun; Tekin, Neslihan; Temel, Halide Edip; Burukoğlu, Dilek; Aral, Erinç (Turkish Biochem Soc, 2012)Aim: Vascular endothelial growth factor production is decreased depending on the alveolar epithelial cell damage. Acute over expression of vascular endothelial growth factor in lung tissue contributes to the formation ... -
Effects of combination of p-dimethylaminoazobenzene and dioxin on serum lipid profile
Objective: The liver cancer initiator p-dimethylaminoazobenzene and the potent liver promoter Dioxin are the environmental pollutants that people may be exposed to those in their daily lives. Butyrylcholinesterase is a ... -
Effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome
Uslu, S.; Özçelik, E.; Kebapçı, N.; Temel, Halide Edip; Demirci, Fatih; Ergün, Bülent; Demirüstü, C. (Springer London LTD, 2016)Background Elevated serum uric acid levels and increased arginase activity are risk factors for cardiovascular diseases (CVD). The aim of the present study was to investigate effects of serum uric acid levels on the arginase ... -
NO levels in diabetes mellitus: Effects of l-NAME and insulin on LCAT, Na+/K+ ATPase activity and lipid profile
Tekin, Neslihan; Akyüz, F.; Temel, Halide Edip (Elsevier Ltd, 2011)Objectives: Diabetes mellitus (DM) is a chronic disease and one of the most important health problems. Several factors may be responsible for the complications of diabetes mellitus including alterations in the activities ... -
Serum Thrombopoietin Levels and Its Relationship With Thrombocytopenia in Patients With Cirrhosis
Temel, Tuncer; Cansu, Dondu Üsküdar; Temel, Halide Edip; Özakyol, Ayşegül Harmancı (Kowsar Publ, 2014)Background: Patients with cirrhosis usually have thrombocytopenia in discrete levels. The mechanism of thrombocytopenia is thought as splenic sequestration and destruction of platelets, impaired bone marrow generation and ... -
Synthesis and Biological Evaluation of Some New Hydrazone Derivatives Bearing Pyrimidine Ring as Analgesic and Anti-Inflammatory Agents
Akdağ, Kadriye; Ünal, Gökhan; Tok, Fatih; Arıcıoğlu, Feyza; Temel, Halide Edip; Koçyiğit-Kaymakçıoğlu, Bedia (Polskie Towarzystwo Farmaceutyczne, 2018)New hydrazone derivatives were synthesized from 4-chloro-2-(methylthio) pyrimidine-5-carbohydrazide. IR, 1H-NMR, 13C-NMR, mass spectral data and elemental analysis characterized synthesized compounds. All compounds were ... -
Synthesis and Evaluation of a New Series of Thiazolyl-pyrazoline Derivatives as Cholinesterase Inhibitors
Temel, Halide Edip; Altıntop, Mehlika Dilek; Özdemir, Ahmet (Turkish Pharmacists Assoc, 2018)Objectives: In recent years, the design of anticholinesterase agents based on molecular hybridization of pharmacologically active scaffolds has attracted a great deal of interest in medicinal chemistry. For this purpose, ...