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Phenolic compounds inhibit the aldose reductase enzyme from the sheep kidney
Demir, Yeliz; Işık, Mesut; Gülçin, İlhami; Beydemir, Şükrü (Wiley, 2017)Aldose reductase (AR) is the key enzyme for the polyol pathway and responsible for sorbitol accumulation during the hyperglycemia. The present article focuses on the role of phenol, pyrogallol, hydroquinone, resorcinol, ... -
Phenolic compounds: The inhibition effect on polyol pathway enzymes
Aslan, Hatice Esra; Beydemir, Şükrü (Elsevier Ireland LTD, 2017)The polyol pathway called as sorbitol way is a small part of glycose metabolism. The pathway is regarded as an important element in the pathogenesis of various diabetic complications in individuals with diabetes mellitus. ... -
Phytase from Weissella halotolerans: purification, partial characterisation and the effect of some metals
Demir, Yeliz; Kotan, Merve Şenol; Dikbas, Neslihan; Beydemir, Şükrü (Taylor & Francis Inc, 2017)In the study, phytase was purified in three simple steps comprising ammonium sulphate precipitation, anion exchange and gel filtration chromatography from Weissella halotolerans. The enzyme was obtained with a specific ... -
Purification and Biochemical Characterization of Phytase Enzyme from Lactobacillus coryniformis (MH121153)
Demir, Yeliz; Dikbas, Neslihan; Beydemir, Şükrü (Humana Press Inc, 2018)Phytase (myo-inositol hexaphosphate phosphohydrolase) belongs to phosphatases. It catalyzes the hydrolysis of phytate to less-phosphorylated inorganic phosphates and phytate. Phytase is used primarily for the feeding of ... -
Purification and characterization of nitric oxide synthase from bovine kidney and investigating drug-induced toxicities of some antibiotics on the enzyme activity
İşgör, M. M.; Ekinci, D.; Beydemir, Şükrü (Bentham Science Publishers B.V., 2017)Introduction: Broad spectrums of antibiotics are widely used in the treatment of bacterial infections, particularly causing Staphylococcus aureus. These drugs have high acute renal injury (AKI) potency due to an increase ... -
Purification of Glucose 6-Phosphate Dehydrogenase From Gilthead Sea Bream (Sparus Aurata) Gill and Liver Tissues and Inhibition Effects of Some Metal Ions on Enzyme Activity
Kırıcı, Mahinur; Kırıcı, Muammer; Beydemir, Şükrü; Bülbül, Metin (Parlar Scientific Publications (PSP), 2017)Fish is one of the most valuable protein sources and vulnerable to all environmental pollution including metals. Metals play vital roles in enzyme activities and other metabolic events with their bioaccumulative and ... -
Purification of glucose 6-phosphate dehydrogenase from gilthead sea bream (Sparus aurata) gill and liver tissues and inhibition effects of some metal ions on enzyme activity
Kırıcı, Muammer; Beydemir, Şükrü; Bülbül, Metin (Parlar Scientific Publications, 2017)Fish is one of the most valuable protein sources and vulnerable to all environmental pollution including metals. Metals play vital roles in enzyme activities and other metabolic events with their bioaccumulative and ... -
Purification of glutathione reductase from some tissues of Capoeta umblaand the inhibitory effects of some metal ions on enzyme activity
Anadolu Üniversitesi, Eczacılık Fakültesi, Biyokimya Anabilim Dalı; 0000-0003-3667-6902; Beydemir, Şükrü (2021)The aim of this study was to determine the in vitro inhibitory effects of some metal ions (silver ion (Ag+), cadmium ion (Cd2+), cobalt ion (Co2+), copper ion (Cu2+), nickel ion (Ni2+), lead ion (Pb2+) ... -
Synthesis, biological evaluation and in silico studies of novel N-substituted phthalazine sulfonamide compounds as potent carbonic anhydrase and acetylcholinesterase inhibitors
Türkeş, Cüneyt; Arslan, Mustafa; Demir, Yeliz; Cocaj, Liridon; Nixha, Arleta Rıfati; Beydemir, Şükrü (Academic Press Inc Elsevier Science, 2019)The synthesis, characterization and biological evaluation of a series of novel N-substituted phthalazine sulfonamide (5a-1) are disclosed. Phthalazines which are nitrogen-containing heterocyclic compounds are biologically ...