A Study on the Polarographic-Behavior and Determination of Tizanidine

Abstract

The direct current polarographic behaviour of tizanidine based on the reduction of the molecule on the surface of DME is described and the optimum polarographic conditions for the determination are presented in this study. The experiments were conducted using supporting electrolyte consisting of 0.2 M KC], 20 (v/v) percent ethanol and buffer solution. One-step polarographic curves were obtained in the supporting electrolyte. The limiting currents remained constant in the 3.15-8.52 pH range and the half-wave potentials of these waves were linearly shifted to more, positive potentials for each decrease of pH. The system is quasi-reversible and controlled by diffusion in the supporting electrolyte at pH 7.2. The results of calibration studies of DC, SIAP, SCAP and DP polarography were performed and evaluated statistically. The determination of tizanidine in a pharmaceutical preparation (Sirdalud) were carried out employing DC and DP polarography among the modes mentioned above. In the analysis of single 2 mg tablets, the relative standard deviations S(rel) are 1.99 +/- 1.1 % (DCP), 2.07 +/- 1.3 % (DPP) and 2.09 +/- 1.2 % (specurophotometric). The determination methods proposed in this study seems to be accurate, rapid and practical. Therefore, they may be suitable for the content uniformity test.