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dc.contributor.authorİnal, M
dc.contributor.authorAlataş, O
dc.contributor.authorKural, T
dc.contributor.authorSevin, B
dc.date.accessioned2019-10-18T18:44:13Z
dc.date.available2019-10-18T18:44:13Z
dc.date.issued1994
dc.identifier.issn0021-9509
dc.identifier.urihttps://hdl.handle.net/11421/10561
dc.descriptionWOS: A1994NP18500009en_US
dc.descriptionPubMed ID: 8195275en_US
dc.description.abstractThis study was performed to observe the effect of myocardial ischemia on the patients undergoing cardiopulmonary bypass (CPB) operation. For this aim, superoxide dismutase (SOD) activities, reduced glutathione (GSH) and lipid peroxide (LP) levels were determined in blood samples which were obtained from the coronary sinus. Sampling times were as follows: (1) Before CPB. (2) Immediately after CPB. (3) Fifteen minutes after the second specimen. (4) Thirty minutes after the second specimen. SOD activities of these groups were 5135.10 +/- 278.51 U/g Hb, 3505.64 +/- 302.09 U/g Hb, 4206.55 +/- 272.25 U/g Hb, 4707.20 +/- 270.91 U/g Hb respectively. Also the LP levels were 1.90 +/- 0.29 nmol MDA/ml, 4.37 +/- 0.52 nmol MDA/ml, 4.09 +/- 0.39 nmol MDA/ml, 2.74 +/- 0.30 nmol MDA/ml respectively. GSH levels were slightly increased during ischemia and reperfusion; 103.27 +/- 5.18 mg/dl, 125.00 +/- 10.36 mg/dl, 125.00 +/- 6.61 mg/dl, 111.18 +/- 8.22 mg/dl respectively. SOD activities were reduced significantly in second group (p < 0.001), in third and fourth groups (p < 0.01) as compared with control group. Also LP levels were increased significantly in all groups (p < 0.001) as compared with controls. Our results confirm the generation of oxygen free radicals from ischemia and reperfusion of heart during CPB. Also it appears that oxygen free radical generation exceeds the capacity of intracellular SOD, which is the most important scavenger of free radical in the cell.en_US
dc.language.isoengen_US
dc.publisherEdizioni Minerva Medicaen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiopulmonary Bypassen_US
dc.subjectFree Radicals, Oxygenen_US
dc.subjectGlutathione, Reduceden_US
dc.subjectLipid Peroxidationen_US
dc.subjectSuperoxide Dismutaseen_US
dc.titleOxygen-Free Radicals in Eyrthrocytes During Open-Heart Operationen_US
dc.typearticleen_US
dc.relation.journalJournal of Cardiovascular Surgeryen_US
dc.contributor.departmentAnadolu Üniversitesien_US
dc.identifier.volume35en_US
dc.identifier.issue2en_US
dc.identifier.startpage147en_US
dc.identifier.endpage150en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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