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Design, synthesis, and biological activity of a novel series of 2,5-disubstituted furans/pyrroles as HIV-1 fusion inhibitors targeting gp41

Jiang, Shibo; Tala, Srinivasa R.; Lu, Hong; Zou, Peng; Avan, İlker; İbrahim, Tarek S.; Katritzky, Alan R. (Pergamon-Elsevier Science LTD, 2011)

Based on molecular docking analysis of earlier results, we designed a series of 2,5-disubstituted furans/pyrroles (5a-h) as HIV-1 entry inhibitors. Compounds were synthesized by Suzuki-Miyaura cross coupling, followed by ...