Design, synthesis, and biological activity of a novel series of 2,5-disubstituted furans/pyrroles as HIV-1 fusion inhibitors targeting gp41
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Erişim
info:eu-repo/semantics/closedAccessTarih
2011Yazar
Jiang, ShiboTala, Srinivasa R.
Lu, Hong
Zou, Peng
Avan, İlker
İbrahim, Tarek S.
Katritzky, Alan R.
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Based on molecular docking analysis of earlier results, we designed a series of 2,5-disubstituted furans/pyrroles (5a-h) as HIV-1 entry inhibitors. Compounds were synthesized by Suzuki-Miyaura cross coupling, followed by a Knoevenagel condensation or Wittig reaction. Four of these compounds were found to be effective in inhibiting HIV-1 infection, with the best compounds being 5f and 5h, which exhibited significant inhibition on HIV-1(IIIB) infection at micromolar levels with low cytotoxicity. These compounds are also effective in blocking HIV-1 mediated cell-cell fusion and the gp41 six-helix bundle formation, suggesting that they are also HIV-1 fusion inhibitors targeting gp41 and have potential to be developed as a new class of anti-HIV-1 agents
Kaynak
Bioorganic & Medicinal Chemistry LettersCilt
21Sayı
22Koleksiyonlar
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