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dc.contributor.authorAggarwal, Vaishali
dc.contributor.authorTuli, Hardeep Singh
dc.contributor.authorVarol, Aysegul
dc.contributor.authorThakral, Falak
dc.contributor.authorYerer, Mukerrem Betul
dc.contributor.authorSak, Katrin
dc.contributor.authorSethi, Gautam
dc.date.accessioned2020-07-09T20:58:56Z
dc.date.available2020-07-09T20:58:56Z
dc.date.issued2019
dc.identifier.issn2218-273X
dc.identifier.urihttps://doi.org/10.3390/biom9110735
dc.identifier.urihttps://hdl.handle.net/11421/24102
dc.descriptionSak, Katrin/0000-0003-0736-2525; Khan, Asaduzzaman/0000-0001-7851-0500; Yerer, Mukerrem B/0000-0002-4503-8032; Tuli, Hardeep Singh/0000-0003-1155-0094; VAROL, Mehmet/0000-0003-2565-453X; Jain, Aklank/0000-0001-5539-3225en_US
dc.descriptionWOS: 000502267900096en_US
dc.descriptionPubMed: 31766246en_US
dc.description.abstractReactive oxygen species (ROS) play a pivotal role in biological processes and continuous ROS production in normal cells is controlled by the appropriate regulation between the silver lining of low and high ROS concentration mediated effects. Interestingly, ROS also dynamically influences the tumor microenvironment and is known to initiate cancer angiogenesis, metastasis, and survival at different concentrations. At moderate concentration, ROS activates the cancer cell survival signaling cascade involving mitogen-activated protein kinase/extracellular signal-regulated protein kinases 1/2 (MAPK/ERK1/2), p38, c-Jun N-terminal kinase (JNK), and phosphoinositide-3-kinase/ protein kinase B (PI3K/Akt), which in turn activate the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B), matrix metalloproteinases (MMPs), and vascular endothelial growth factor (VEGF). At high concentrations, ROS can cause cancer cell apoptosis. Hence, it critically depends upon the ROS levels, to either augment tumorigenesis or lead to apoptosis. the major issue is targeting the dual actions of ROS effectively with respect to the concentration bias, which needs to be monitored carefully to impede tumor angiogenesis and metastasis for ROS to serve as potential therapeutic targets exogenously/endogenously. Overall, additional research is required to comprehend the potential of ROS as an effective anti-tumor modality and therapeutic target for treating malignancies.en_US
dc.language.isoengen_US
dc.publisherMdpien_US
dc.relation.isversionof10.3390/biom9110735en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectreactive oxygen species (ROS)en_US
dc.subjectoxidative stressen_US
dc.subjectinflammationen_US
dc.subjectangiogenesisen_US
dc.subjectmetastasisen_US
dc.subjectmiRNAen_US
dc.titleRole of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancementsen_US
dc.typereviewen_US
dc.relation.journalBiomoleculesen_US
dc.contributor.departmentAnadolu Üniversitesien_US
dc.identifier.volume9en_US
dc.identifier.issue11en_US
dc.relation.publicationcategoryDiğeren_US


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