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dc.contributor.authorOzturk, A. Alper
dc.contributor.authorKiyan, H. Tuba
dc.date.accessioned2020-07-09T20:58:44Z
dc.date.available2020-07-09T20:58:44Z
dc.date.issued2020
dc.identifier.issn0026-2862
dc.identifier.issn1095-9319
dc.identifier.urihttps://doi.org/10.1016/j.mvr.2019.103961
dc.identifier.urihttps://hdl.handle.net/11421/23995
dc.descriptionOzturk, A. Alper/0000-0001-9596-0538en_US
dc.descriptionWOS: 000509423500019en_US
dc.descriptionPubMed: 31758946en_US
dc.description.abstractAngiogenesis is a fundamental process of wound healing, embryogenesis etc. but occurs in cancer and chronic inflammation pathologically. HET-CAM assay is a useful, well established and animal alternative test to screen anti-inflammatory potentials of pharmaceutical products as well as nano-formulations. Dexketoprofen trometamol (DT) belongs to the nonsteroidal anti-inflammatory drug (NSAID) group which is a rapidly acting analgesic ingredient. Because DT has a short half-life, high and frequent dosing is used in treatment. the need of design and producing a new oral prolonged-release dosage form containing DT is the major aim of the study with low dose and low side effects. Chitosan (CS) has been widely used in the pharmaceutical area because of its favorable biological properties. in this study, DT loaded CS nanoparticles (CS-NPs) were produced by spray drying method for oral drug delivery. Structures of CS-NPs were elucidated by particle size, zeta potential, SEM, DSC, FT-IR and H-1 NMR. High encapsulation efficiency was obtained (73-84%) for the prepared formulations. in vitro release was examined in pH 1.2 buffer and pH 6.8 buffer. DT-loaded CS-NPs showed prolonged release, particularly at pH 6.8. Weibull kinetic model was found to fit best to DT release from CS-NPs in both release medium. the anti-inflammatory activity of optimum formulation (M-DT) was examined using the in vivo HET-CAM assay. the anti-inflammatory activity results indicated that M-DT coded NPs formulation showed significantly good anti-inflammatory potential with closer inhibition value to the standard anti-inflammatory DT at one fifth lower dosage. According to the proposed method and results it can be successfully applicable to the NP preparation containing DT and it could be concluded that DT loaded CS-NPs seem to be a promising prolonged release drug delivery system for oral administration with low dose and high efficiency.en_US
dc.language.isoengen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.isversionof10.1016/j.mvr.2019.103961en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChitosanen_US
dc.subjectDexketoprofen trometamolen_US
dc.subjectSpray drying techniqueen_US
dc.subjectNanoparticleen_US
dc.subjectDrug deliveryen_US
dc.subjectChronic painen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectin vivo HET-CAM assayen_US
dc.titleTreatment of oxidative stress-induced pain and inflammation with dexketoprofen trometamol loaded different molecular weight chitosan nanoparticles: Formulation, characterization and anti-inflammatory activity by using in vivo HET-CAM assayen_US
dc.typearticleen_US
dc.relation.journalMicrovascular Researchen_US
dc.contributor.departmentAnadolu Üniversitesien_US
dc.identifier.volume128en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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