Güncel Gönderiler: PubMed İndeksli Yayınlar Koleksiyonu
Toplam kayıt 1498, listelenen: 41-60
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Effect of different molecular weight PLGA on flurbiprofen nanoparticles: formulation, characterization, cytotoxicity, and in vivo anti-inflammatory effect by using HET-CAM assay
(Taylor & Francis Ltd, 2020)Objective: the effect of polymers used in nanoparticle (NP) production on the formulation properties is one of the few studied issues. Therefore, this study aims to formulate flurbiprofen (FLB) loaded NPs with different ... -
Sulfonamides incorporating ketene N,S-acetal bioisosteres as potent carbonic anhydrase and acetylcholinesterase inhibitors
(Wiley-V C H Verlag Gmbh, 2020)In this study, 15 novel compounds in a series of sulfonamide-based ketenes (7a-o) were synthesized and characterized using Fourier-transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and mass spectrometry. ... -
Secondary metabolites from Verbascum bugulifolium Lam. and their bioactivities
(Taylor & Francis Ltd, 9999)Five iridoid glycosides catalpol (1), specioside (2), ajugol (3), ajugoside (4), 8-O-acetylharpagide (5), two phenylethanoid glycosides, verbascoside (6) and glucopyranosyl-(1 -> G(i)-6)-martynoside (7), four flavonoids, ... -
Potential Antioxidant and Enzyme Inhibitory Effects of Nanoliposomal Formulation Prepared from Salvia aramiensis Rech. f. Extract
(Mdpi, 2020)Salvia aramiensis Rech. f. is a species that grows only in Hatay, Turkey and is used as a traditional stomachic tea. Neither the chemical composition nor the potential bioactivity of the plant has been investigated before. ... -
Synthesis, Docking Studies and Biological Activity of New Benzimidazole- Triazolothiadiazine Derivatives as Aromatase Inhibitor
(Mdpi, 2020)In the last step of estrogen biosynthesis, aromatase enzyme catalyzes the conversion of androgens to estrogens. Aromatase inhibition is an important way to control estrogen-related diseases and estrogen levels. in this ... -
Chemical Characterization and Biological Activity of the Mastic Gum Essential Oils of Pistacia lentiscus var. chia from Turkey
(Mdpi, 2020)The essential oils (EOs) were isolated by hydrodistillation from wild and cultivated Pistacia lentiscus L. var. chia-mastic gum tree (Anacardiaceae) from two natural habitats, namely from Cesme-Uzunkoy (1) and Mordogan ... -
Anticancer and antimetastatic activity of Hypomyces chrysospermus, a cosmopolitan parasite in different human cancer cells
(Springer, 2020)The importance of microbial natural compounds in drug research is increasing every year and they are used to prevent or treat a variety of diseases. Hypomyces chrysospermus is a cosmopolitan parasite of many Boletaceae ... -
Synthesis, characterization, biological evaluation, and in silico studies of novel 1,3-diaryltriazene-substituted sulfathiazole derivatives
(Wiley-V C H Verlag Gmbh, 9999)In the present study, a series of eleven novel 1,3-diaryltriazene-substituted sulfathiazole moieties (ST1-11) was synthesized by the reaction of diazonium salt of sulfathiazole with substituted aromatic amines and their ... -
Development of a RP-HPLC method for simultaneous determination of reference markers used for in-situ rat intestinal permeability studies
(Elsevier, 2020)One of the most common techniques for assessing the intestinal absorption characteristics of drugs is single-pass intestinal perfusion (SPIP) method. Metoprolol tartrate (MT, reference standard) and phenol red (PR, zero ... -
RuBisCO nano enzyme for mimicking CO(2)conversion system in plants
(Wiley, 9999)In this study, carbon dioxide (CO2) capture and conversion systems based on the combination of biomimetic systems with nano enzymes have been developed. the effectiveness of the developed system has been investigated toward ... -
Diclofenac sodium loaded PLGA nanoparticles for inflammatory diseases with high anti-inflammatory properties at low dose: Formulation, characterization and in vivo HET-CAM analysis
(Academic Press Inc Elsevier Science, 2020)The development of a new drug active substance is not only time-consuming and expensive, but also a chain of operations that often fails. However, increasing the bioavailability, effectiveness, safety, or targeting the ... -
Synthesis, characterization and carbonic anhydrase I and II inhibitory evaluation of new sulfonamide derivatives bearing dithiocarbamate
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2020)In this study, novel dithiocarbamate-sulfonamide derivatives (3a-3k) were synthesized to investigate their inhibitory activity on purified human carbonic anhydrase (hCA) I and II. the IC50 and Ki values of the compounds ... -
The use of ecological footprint in estimating the Environmental Kuznets Curve hypothesis for BRICST by considering cross-section dependence and heterogeneity
(Elsevier, 2020)A vast body of literature estimates the impact of economic growth on environmental degradation in the framework of EKC model. Typical empirical studies proxy environmental degradation with CO2 emissions; however, this ... -
Synthesis, characterization, and in vivo pharmacological evaluation of novel mannich bases derived from 1,2,4-triazole containing a naproxen moiety
(Academic Press Inc Elsevier Science, 2020)… -
Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as possible anticancer agents
(Hrvatsko Farmaceutsko Drustov (Hfd)-Croation Pharmaceutical Soc, 2020)The synthesis of new N-(5-substituted-1,3,4-thiadiazol-2-yl)-2-[5-(substituted amino)-1,3,4-thiadiazol-2-yl)thiolacetamide derivatives and investigation of their anticancer activities were the aims of this work. All the ... -
Rutamarin: Efficient Liquid-Liquid Chromatographic Isolation from Ruta graveolens L. and Evaluation of Its In Vitro and In Silico MAO-B Inhibitory Activity
(NLM (Medline), 2020)Naturally occurring coumarins are a group of compounds with many documented central nervous system (CNS) activities. However, dihydrofuranocoumarins have been infrequently investigated for their bioactivities at CNS level. ... -
The adverse effects of psychotropic drugs as an endocrine disrupting chemicals on the hypothalamic-pituitary regulation in male
(Elsevier Inc., 2020)Adverse effects of drugs on male reproductive system can be categorized as pre-testicular, testicular, and post-testicular. Pre-testicular adverse effects disrupt the hypothalamic–pituitary–gonadal (HPG) axis, generally ... -
Molecular docking studies and inhibition properties of some antineoplastic agents against paraoxonase-I
(Bentham Science Publishers, 2020)Background: Currently, most of the drugs used in clinical applications show their pharmacological influences by inhibiting or activating enzymes. Therefore, enzyme inhibitors have an essential place in the drug design for ... -
Novel approaches to cancer therapy with ibuprofen-loaded Eudragit® RS 100 and/or octadecylamine-modified PLGA nanoparticles by assessment of their effects on apoptosis
(Taylor and Francis Ltd., 2020)Objective: The purpose of this study was the design ibuprofen (IBU)-loaded unique Eudragit® RS 100 (ERS) and/or octadecylamine modified PLGA nanoparticles (NPs) for cancer treatment. Significance: The rational for this ...
