Güncel Gönderiler: PubMed İndeksli Yayınlar Koleksiyonu
Toplam kayıt 1498, listelenen: 1021-1040
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MgSO 4 and lazaroid (U-83836E) partially protects glioma cells against glutamate toxidty in vitro
(2004)In this study, the possible effects of MgSO 4 and lazaroid (U-83836E) on glutamate toxicity on glial cells were investigated. C6 and human glioblastoma multiforme cells derived from two patients were grown in an incubator. ... -
Analgesic and antispasmodic activities of 2-(2-nitro-phenyl)-1 H-benzimidazole 5-carboxylic acid: Evidence for the importance of the 2-(o-substituted phenyl) group
(2003)Benzimidazole 5-carboxylic acid derivatives were investigated for analgesic activity in this study. Of the benzimidazole compounds tested, 2-(2-nitro-phenyl)-1 H-benzimidazole 5-carboxylic acid showed remarkable naloxone ... -
Decreased Beta-Adrenergic Responses of Rat Small-Intestine Due to Non-Insulin-Dependent Diabetes
(Elsevier Sci Ireland LTD, 1990)… -
New beta-diketone and 3,5-dimethyl isoxazole derivatives of theophylline as potential bronchodilator agents
(Ecv-Editio Cantor Verlag Medizin Naturwissenschaften, 1998)Ten new compounds having 7-[(2,4-pentanedione-3-yl)alkyl]- and 7-[(3,5-dimethylisoxazole-4-yl)alkyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione structures were synthesized and their bronchodilator activities investigated ... -
Effect of an aqueous distillate of Origanum onites L. on isolated rat fundus, duodenum and ileum: Evidence for the role of oxygenated monoterpenes
(Govi-Verlag Pharmazeutischer Verlag GMBH, 2005)The aqueous distillate of Origanum onites L. (Labiatae) was reported to have various ethnomedical uses including effects on the gastrointestinal tract. The effects of three different doses (0.1, 0.2 and 0.4 mL) of the ... -
Wound-healing activity of St. John's Wort (Hypericum perforatum L.) on chicken embryonic fibroblasts
(Elsevier Ireland LTD, 2007)Wound-healing effect of St. John's Wort (Hypericum perforatum L.) extract was evaluated by comparing with dexpanthenol and titrated extract of Centella asiatica TECA) on cultured chicken embryonic fibroblasts. Chicken ... -
Testing wound-healing activity in T15 fibroblast cultures: A morphometric analysis
(Frame, 2000)The purpose was to evaluate the use of mouse T15 fibroblast cell cultures for the investigation of wound-healing activity. In order to investigate their mechanisms of action, the effects of drugs with wound-healing activities ... -
Analgesic activity of Nepeta italica L.
(John Wiley & Sons LTD, 1999)A screening study was performed on/by essential oils of Nepeta viscida Boiss and Nepeta italica L. using tail-flick and tail immersion (52.5 degrees C) methods, N. italica samples were collected from three different ... -
Nepetalactone: A new opioid analgesic from Nepeta caesarea Boiss.
(Royal Pharmaceutical Soc Great Britain, 1998)The essential oils of Nepeta species including Nepeta phyllochlamys P. H. Davis, N. nuda L. ssp. nude, and N. caesarea Boiss. have been screened by use of the tail-flick and tail immersion (52.5 degrees C) methods. Of the ... -
Effects of streptozotocin-induced diabetes and insulin on calcium responsiveness of the rat vas deferens
(Pergamon-Elsevier Science LTD, 2006)In the present study, effects of streptozotocin-induced diabetes and insulin treatment on the reactivity of rat vas deferens to KCl and calmidazolium, a calmodulin antagonist, were evaluated and calmodulin levels in vas ... -
Analgesic and antispasmodic activities of 2-(2-nitro-phenyl)-1H-benzimidazole 5-carboxylic acid: evidence for the importance of the 2-(o-substituted phenyl) group
(Govi-Verlag GMBH, 2003)Benzimidazole 5-carboxylic acid derivatives were investigated for analgesic activity in this study. Of the benzimidazole compounds tested, 2-(2-nitro-phenyl)-1 H-benzimidazole 5-carboxylic acid showed remarkable naloxone ... -
Kinin receptors and their antagonists as novel therapeutic agents
(Bentham Science Publ LTD, 2001)Plasma kinins are a family of peptides which play an important role in a variety of pathophysiological conditions. As a consequence of the progress in the area of kinin receptors, specific kinin receptor antagonists will ... -
Central Nervous System Activities of Hypericum origanifolium Extract via GABAergic and Opioidergic Mechanisms
(Wiley, 2013)Pharmacological effects of hydroalcoholic extract prepared from Hypericum origanifolium Willd. (Guttiferae) on behavioral parameters and pain perceptions of mice were investigated in this study. Depression, anxiety, ... -
Calmodulin content and in vitro contractility of duodenum from streptozotocin-induced diabetic rats: Effects of insulin therapy and calmodulin antagonism
(Elsevier Science BV, 1997)The effects of experimental diabetes and insulin treatment on the decreased reactivity of isolated rat duodenum to KCI and calmidazolium, a specific calmodulin antagonist, were examined. After 8 weeks of streptozotocin ... -
Synthesis of Novel Benzazole Derivatives and Evaluation of Their Antidepressant-Like Activities with Possible Underlying Mechanisms
(MDPI, 2018)Novel benzazole derivative compounds 4a-4h were obtained by the reaction of corresponding 2-(benzazol-2-ylthio)acetohydrazide and appropriate 4-substituted benzaldehydes. The chemical structures of the synthesized compounds ... -
Valnoctamide: The effect on relieving of neuropathic pain and possible mechanisms
(Elsevier Science BV, 2018)The purpose of this study is to assess the possible anti-allodynic and antihyperalgesic effect of valnoctamide, an amide derivative of valproic acid, at the doses of 40, 70 and 100 mg/kg (i.p.) in neuropathic pain model ... -
An in vivo database model for pharmacological and physiological dosage for experimental animals
(Pergamon-Elsevier Science LTD, 2009)We developed a database compiling in vivo doses of compounds for various activities in certain animal species. The related database covers almost 100 years of experiments. The conceptual scheme of the database was created ... -
A Computer Experiment Model to Investigate the Effects of Drug Dosage in Animals, for Use in Pharmacological Education and Research
(Frame, 2011)The ACD-IDEA database, which was originally developed by the authors in 2004, is an ongoing compilation of existing data on the in vivo doses of compounds at which various responses in certain animal species have been ... -
Interesting linkage between wound healing and hepatoprotective activities
(Elsevier Ireland LTD, 2011)… -
Synthesis and Antidepressant Activity Profile of Some Novel Benzothiazole Derivatives
(MDPI, 2017)Within the scope of our new antidepressant drug development efforts, in this study, we synthesized eight novel benzothiazole derivatives 3a-3h. The chemical structures of the synthesized compounds were elucidated by ...
