Bölüm "Anadolu Üniversitesi, Eczacılık Fakültesi, Biyokimya Anabilim Dalı" PubMed İndeksli Yayınlar Koleksiyonu için listeleme
Toplam kayıt 44, listelenen: 1-20
-
Anti-diabetic Properties of Calcium Channel Blockers: Inhibition Effects on Aldose Reductase Enzyme Activity
(Springer, 2019)Aldose reductase (AR) belongs to NADPH-dependent oxidoreductases and converts glucose to sorbitol in the polyol pathway. AR inhibition is essential to prevent diabetic complications. Here, AR was purified from sheep kidney ... -
Antidiabetic potential: In vitro inhibition effects of bromophenol and diarylmethanones derivatives on metabolic enzymes
(Wiley-V C H Verlag GMBH, 2018)Aldose reductase converts glucose to sorbitol in the polyol pathway. It is an important enzyme to prevent diabetic complications. In this study, we studied the inhibitory effects of bromophenol derivatives on aldose reductase ... -
Antiepileptic drugs: Impacts on human serum paraoxonase-1
(Wiley, 2017)Serum paraoxonase (PON1) is a key enzyme related to high-density lipoprotein (HDL)-cholesterol particle. It can prevent the oxidation of low-density lipoprotein (LDL) and HDL. The present article focuses on the in vitro ... -
Apoptotic effects of epsilon-viniferin in combination with cis-platin in C6 cells
(Springer, 2018)Glioblastoma (GBM) is one of the most common and lethal forms of primary brain tumors in human adults. Treatment options are limited, and in most cases ineffective. Natural products are sources of novel compounds endowed ... -
An approach to clarify the effect mechanism of glyphosate on body malformations during embryonic development of zebrafish (Daino rerio)
(Pergamon-Elsevier Science LTD, 2017)In this study, it has been investigated that the effects of glyphosate, which is a herbicide within organophosphate and unselective widely used in agriculture on enzyme activity of carbonic anhydrase, production of reactive ... -
Butrylcholinesterase Activity in Chronic Liver Disease Patients and Correlation with Child-Pugh Classification and MELD Scoring System
(Clin Lab Publ, 2015)Background: After 40 years since establishment of Child-Pugh staging, 14 years since establishment of MELD scoring system, and 25 years since establishment of King's College Criteria, there is still a search for more ... -
Cytotoxic, Antiproliferative and Apoptotic Effects of Perillyl Alcohol and Its Biotransformation Metabolite on A549 and HepG2 Cancer Cell Lines
(Bentham Science Publ LTD, 2017)Background: A monoterpene, perillyl alcohol, has attracted attention in medicinal chemistry since it exhibited chemo-preventive and therapeutic properties against a variety of cancers. Objective: In the present work, it ... -
Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, alpha-amylase and alpha-glycosidase inhibitors as new therapeutic approach in diabetes and functional hyperglycemia
(Elsevier Science BV, 2018)Diabetes mellitus (DM) is a chronic metabolic disease in which there are high blood sugar levels over a prolonged period. Aldose reductase (AR) belongs to aldo-keto reductase superfamily and plays a key role in the polyol ... -
Direct and protective effects of single or combined addition of vincristine and epsilon-viniferin on human HepG2 cellular oxidative stress markers in vitro
(Springer, 2016)The objective of this study is to examine the direct effects of low doses and high doses of epsilon-viniferin, a substance known to be an antioxidant, and vincristine sulphate, a chemotherapeutic agent, alone and in ... -
Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base
(Wiley, 2017)Compounds containing nitrogen and sulfur atoms can be widely used in various fields, including industry, medicine, biotechnology, and chemical technology. Among them, amides of acids and heterocyclic compounds have an ... -
The effects of atorvastatin on antioxidant/antiinflammatory properties of HDLs in hypercholesterolemics
(Tubitak Scientific & Technical Research Council Turkey, 2015)Background/aim: Hypercholesterolemia is characterized by changes in lipid profile, nitric oxide pathway, and oxidative stress markers, but functions of high-density lipoprotein (HDL) were not well established in ... -
The effects of captopril and losartan on erythrocyte membrane Na1+/K1+ - ATPase activity in experimental diabetes mellitus
(2007)Diabetes mellitus induces a decrease in sodium potassium-adenosine triphosphatase (Na+/K+ - ATPase) activity in several tissues in the rat and red blood cells (RBC) and nervous tissue in human patients. This decrease in ... -
Effects of fibronectin and type IV collagen on osteosarcoma cell apoptosis
(Natl Inst Science Communication-Niscair, 2013)The aims of this study are the investigation of the effects of fibronectin and type IV collagen extracellular matrix proteins and the role of caspase-3 and -9 on cis-platin induced U2-OS apoptosis were studied. First the ... -
Effects of lipoprotein-associated phospholipase A2 on arginase/nitric oxide pathway in hemodialysis patients
(2012)Lipoprotein-associated phospholipase A2 (Lp-PLA2) and arginase are recently described inflammatory biomarkers associated with cardiovascular disease. In this study, we aimed to investigate the possible effects of serum ... -
Effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome
(Springer London LTD, 2016)Background Elevated serum uric acid levels and increased arginase activity are risk factors for cardiovascular diseases (CVD). The aim of the present study was to investigate effects of serum uric acid levels on the arginase ... -
The effects of some cephalosporins on acetylcholinesterase and glutathione S-transferase: an in vivo and in vitro study
(Taylor & Francis LTD, 2019)Background: Glutathione S-transferase (GST) and acetylcholinesterase (AChE) are important enzymes in the metabolism. GSTs are primarily available in phase II metabolism. AChE is vital for neurodegenerative disorders. ... -
Escin reduces cell proliferation and induces apoptosis on glioma and lung adenocarcinoma cell lines
(Springer, 2015)Aesculus hippocastanum (the horse chestnut) seed extract has a wide variety of biochemical and pharmacological effects including anti-inflammatory, antianalgesic, and antipyretic activities. The main active compound of ... -
Evaluation of chalcones as inhibitors of glutathione S-transferase
(Wiley, 2018)Glutathione S-transferases (GSTs) are the superfamily of multifunctional detoxification isoenzymes and play an important role in cellular signaling. In the present study, potential inhibition effects of chalcones were ... -
Fe3O4 Nanopowders: Genomic and Apoptotic Evaluations on A549 Lung Adenocarcinoma Cell Line
(Routledge Journals, Taylor & Francis LTD, 2019)The magnetite nanoparticles are progressively used in a wide range of biological applications. In the present study, we purposed to show apoptosis-inducing ability of Fe3O4 nanopowders on A549 cells. In addition, the toxic ... -
Gadolinium-based contrast agents: in vitro paraoxonase 1 inhibition, in silico studies
(Taylor & Francis LTD, 2019)Medications show their biological effects by interaction with enzymes, which have been known to play an essential role in the pathogenesis of many diseases. Inhibition or induction of drug metabolizing enzymes has an ...