Yayıncı "Elsevier France-Editions Scientifiques Medicales Elsevier" PubMed İndeksli Yayınlar Koleksiyonu için listeleme
Toplam kayıt 35, listelenen: 21-35
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Synthesis and antituberculosis activity of new thiazolylhydrazone derivatives
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2008)The increasing clinical importance of drug-resistant mycobacterial pathogens has lent additional urgency to microbiological research and new antimycobacterial compound development. For this purpose, new thiazolylhydrazone ... -
Synthesis and antituberculosis activity of some N-pyridyl-N '-thiazolylhydrazine derivatives
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)In this study, new N-(1-arylethylidene)-N'-(4-arylthiazol-2-yl)hydrazine derivatives were synthesized and evaluated for their antituberculosis activity. The chemical structures of the compounds were elucidated by IR, NMR ... -
Synthesis and biological evaluation of new naphthalene substituted thiosemicarbazone derivatives as potent antifungal and anticancer agents
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)New thiosemicarbazone derivatives (1-10) were obtained via the reaction of 4-(naphthalen-1-yl)thiosemicarbazide with fluoro-substituted aromatic aldehydes. The synthesized compounds were evaluated for their in vitro ... -
Synthesis and biological evaluation of some hydrazone derivatives as new anticandidal and anticancer agents
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2012)New hydrazone derivatives were synthesized via the nucleophilic addition-elimination reaction of 2-[(1-methyl-1H-tetrazol-5-yl]thio)]acetohydrazide with aromatic aldehydes/ketones. The compounds were tested in vitro against ... -
Synthesis and biological evaluation of thiazoline derivatives as new antimicrobial and anticancer agents
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2014)N'-(3,4-Diarylthiazol-2(3H)-ylidene)-2-(arylthio)acetohydrazides were synthesized and evaluated for their antimicrobial activity and cytotoxicity against NIH/3T3 cells. Compound 22 bearing 1-phenyl-1H-tetrazole and ... -
Synthesis and evaluation of bis-thiazole derivatives as new anticancer agents
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)New bis-thiazole derivatives (1-10) were synthesized via the ring closure of 1,1'-(3,3'-dimethoxybipheny1-4,4'-diyl)bis(thiourea) with phenacyl bromides and evaluated for their cytotoxic effects on A549 human lung ... -
Synthesis and evaluation of new benzodioxole-based dithiocarbamate derivatives as potential anticancer agents and hCA-I and hCA-II inhibitors
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)In the current work, new benzodioxole-based dithiocarbamate derivatives were synthesized via the reaction of N-(1,3-benzodioxol-5-ylmethyl)-2-chloroacetamide with appropriate sodium salts of N,N-disubstituted dithiocarbamic ... -
Synthesis and evaluation of new indole-based chalcones as potential antiinflammatory agents
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2015)In the present work, new indole-based chalcone derivatives were obtained via the reaction of 5-substituted-1H-indole-3-carboxaldehydes/1-methylindole-3-carboxaldehyde with appropriate acetophenones. The synthesized compounds ... -
Synthesis and the selective antifungal activity of 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine derivatives
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)Even though there are new classes of compounds now frequently used in treatment of fungal infections, the density of deeply invasive candidiasis has increased at least 10-fold during the past decade. Furthermore, many ... -
Synthesis of 2-substituted-N-[4-(1-methyl-4,5-diphenyl-1H-imidazole-2-yl) phenyl]acetamide derivatives and evaluation of their anticancer activity
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)In the present study 18 novel imidazole-(benz)azole and imidazole-piperazine derivatives were synthesized in order to investigate their probable anticancer activity. The structures of the compounds were confirmed by IR, ... -
Synthesis of new donepezil analogues and investigation of their effects on cholinesterase enzymes
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)Donepezil (DNP), an acetylcholinesterase (AChE) inhibitor, is one of the most preferred choices in Alzheimer diseases (AD) therapy. In the present study, 38 new DNP analogues were synthesized. Structures of the synthesized ... -
Synthesis of some 2-[(benzazole-2-yl)thioacetylamino]thiazole derivatives and their antimicrobial activity and toxicity
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2004)Some 2-[(benzazole-2-yl)thioacetylamino]thiazole derivatives (III) were synthesized by reacting 4-methyl-2-(chloroacetylamino)thiazole derivatives (I) with benzazol-2-thiole (II) in acetone in the presence of K2CO3. The ... -
Synthesis of some triazolyl-antipyrine derivatives and investigation of analgesic activity
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2001)The synthesis of some triazolyl-antipyrine derivatives starting from 4-chloroacetamidoantipyrine and 3-(aryloxyalkyl)-4-ethyl/phenyl-5-mercapto-1,2,4-triazoles is described. The chemical structures of the compounds were ... -
The synthesis, antifungal and apoptotic effects of triazole-oxadiazoles against Candida species
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)In search of potent and safe antifungal agents, herein, we report the synthesis, characterization and biological activities of triazole-oxadiazole compounds. The structural verification of the molecules was carried out by ... -
Synthesis, characterization and carbonic anhydrase I and II inhibitory evaluation of new sulfonamide derivatives bearing dithiocarbamate
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2020)In this study, novel dithiocarbamate-sulfonamide derivatives (3a-3k) were synthesized to investigate their inhibitory activity on purified human carbonic anhydrase (hCA) I and II. the IC50 and Ki values of the compounds ...