Yazar "Levent, Serkan" için PubMed İndeksli Yayınlar Koleksiyonu listeleme
-
Synthesis and docking study of benzimidazole-triazolothiadiazine hybrids as aromatase inhibitors
Cevik, Ulviye Acar; Saglik, Begum N.; Osmaniye, Derya; Levent, Serkan; Cavusoglu, Betul Kaya; Karaduman, Abdullah B.; Kaplancikli, Zafer A. (Wiley-V C H Verlag Gmbh, 2020)Aromatase is involved in the biosynthesis of estrogen and thus is a critical target for breast cancer. in this study, to identify new aromatase enzyme inhibitors, seven 3-[4-(5-methyl-1H-benzo[d]imidazol-2-yl)phenyl]-6-( ... -
Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Potent Antifungal Agents
Karaburun, Ahmet Çağrı; Çevik, Ulviye Acar; Osmaniye, Derya; Sağlık, Begüm Nurpelin; Kaya Çavuşoğlu, Betül; Levent, Serkan; Kaplancıklı, Zafer Asım (MDPI, 2018)With the goal of obtaining a novel bioactive compound with significant antifungal activity, a series of 1,3,4-thiadiazole derivatives (3a-3l) were synthesized and characterized. Due to thione-thiol tautomerism in the ... -
Synthesis of New Hydrazone Derivatives for MAO Enzymes Inhibitory Activity
Can, Nafiz Öncü; Osmaniye, Derya; Levent, Serkan; Sağlık, Begüm Nurpelin; İnci, Beril; Ilgın, Sinem; Kaplancıklı, Zafer Asım (MDPI, 2017)In the present work, 14 new 1-substituted-2-phenylhydrazone derivatives were synthesized to evaluate their inhibitory activity against hMAO enzymes. The structures of the newly synthesized hydrazones 2a-2n were characterized ... -
Synthesis of Oxadiazole-Thiadiazole Hybrids and Their Anticandidal Activity
Levent, Serkan; Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Osmaniye, Derya; Çevik, Ulviye Acar; Atlı Eklioğlu, Özlem; Kaplancıklı, Zafer Asım (MDPI AG, 2017)In the field of infection management, it is a major challenge to discover a potent and safe antifungal agent due to the emergence of resistant strains. Hence, the goal of this paper is to design and synthesize novel ... -
Synthesis of some novel 2-substituted benzothiazole derivatives containing benzylamine moiety as monoamine oxidase inhibitory agents
Kaya, Betül; Sağlık, Begüm Nurpelin; Levent, Serkan; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2016)In the present work, 12 new 2-(5-substituted-benzothiazol-2-ylsulfanyl)-N-(substitutedbenzyl)-N-(4-substitutedphenyl) acetamide derivatives (4a-l) was designed and synthesized. The structures of the synthesized compounds ... -
Synthesis, characterization and carbonic anhydrase I and II inhibitory evaluation of new sulfonamide derivatives bearing dithiocarbamate
Saglik, Begum Nurpelin; Osmaniye, Derya; Cevik, Ulviye Acar; Levent, Serkan; Cavusoglu, Betul Kaya; Buyukemir, Oya; Kaplancikli, Zafer Asim (Elsevier France-Editions Scientifiques Medicales Elsevier, 2020)In this study, novel dithiocarbamate-sulfonamide derivatives (3a-3k) were synthesized to investigate their inhibitory activity on purified human carbonic anhydrase (hCA) I and II. the IC50 and Ki values of the compounds ... -
Synthesis, cytotoxicities, and carbonic anhydrase inhibition potential of 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones
Bilginer, Sinan; Gul, Halise Inci; Erdal, Feyza Sena; Sakagami, Hiroshi; Levent, Serkan; Gulcin, Ilhami; Supuran, Claudiu T. (Taylor & Francis Ltd, 2019)In this study, new chalcone compounds having the chemical structure of 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones (1?8) were synthesised and were characterised by H-1-NMR, C-13?-NMR, and HRMS spectra. Cytotoxic and carbonic ... -
Synthesis, Docking Studies and Biological Activity of New Benzimidazole- Triazolothiadiazine Derivatives as Aromatase Inhibitor
Cevik, Ulviye Acar; Cavusoglu, Betuel Kaya; Saglik, Beguem Nurpelin; Osmaniye, Derya; Levent, Serkan; Ilgin, Sinem; Kaplancikli, Zafer Asim (Mdpi, 2020)In the last step of estrogen biosynthesis, aromatase enzyme catalyzes the conversion of androgens to estrogens. Aromatase inhibition is an important way to control estrogen-related diseases and estrogen levels. in this ... -
Synthesis, molecular docking analysis and carbonic anhydrase I-II inhibitory evaluation of new sulfonamide derivatives
Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Osmaniye, Derya; Levent, Serkan; Kaya Çavuşoğlu, Betül; Demir, Y. (NLM (Medline), 2019)New sulfonamide-hydrazone derivatives (3a-3n) were synthesized to evaluate their inhibitory effects on purified human carbonic anhydrase (hCA) I and II. The inhibition profiles of the synthesized compounds on hCA I-II ... -
Synthesis, structure elucidation, and in vitro pharmacological evaluation of novel polyfluoro substituted pyrazoline type sulfonamides as multi-target agents for inhibition of acetylcholinesterase and carbonic anhydrase I and II enzymes
Yamali, Cem; Gul, Halise Inci; Kazaz, Cavit; Levent, Serkan; Gulcin, Ilhami (Academic Press Inc Elsevier Science, 2020)A novel series of 4-(3-(difluorophenyl)-5-(dimethoxyphenyl)-4,5-dihydropyrazol-1-yl)benzenesulfonamides 1-8 were designed since sulfonamide and pyrazoline pharmacophores draw great attention in novel drug design due to ...