Yazar "Taslimi, Parham" için Eczacılık Fakültesi listeleme
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Antidiabetic potential: In vitro inhibition effects of bromophenol and diarylmethanones derivatives on metabolic enzymes
Demir, Yeliz; Taslimi, Parham; Özaslan, Muhammet Serhat; Öztaşkın, Necla; Çetinkaya, Yasin; Gülçin, İlhami; Göksu, Süleyman (Wiley-V C H Verlag GMBH, 2018)Aldose reductase converts glucose to sorbitol in the polyol pathway. It is an important enzyme to prevent diabetic complications. In this study, we studied the inhibitory effects of bromophenol derivatives on aldose reductase ... -
Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, alpha-amylase and alpha-glycosidase inhibitors as new therapeutic approach in diabetes and functional hyperglycemia
Taslimi, Parham; Aslan, Hatice Esra; Demir, Yeliz; Öztaşkın, Necla; Maras, Ahmet; Gülçin, İlhami; Göksu, Süleyman (Elsevier Science BV, 2018)Diabetes mellitus (DM) is a chronic metabolic disease in which there are high blood sugar levels over a prolonged period. Aldose reductase (AR) belongs to aldo-keto reductase superfamily and plays a key role in the polyol ... -
Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base
Taslimi, Parham; Osmanova, Sabiya; Gülçin, İlhami; Sardarova, Sabira; Farzaliyev, Vagif; Sujayev, Afsun; Kufrevioğlu, Ömer İrfan (Wiley, 2017)Compounds containing nitrogen and sulfur atoms can be widely used in various fields, including industry, medicine, biotechnology, and chemical technology. Among them, amides of acids and heterocyclic compounds have an ... -
Synthesis and bioactivity of several new hetaryl sulfonamides
Taslimi, Parham; Sujayev, Afsun; Mamedova, Sevgi; Kalin, Pınar; Gülçin, İlhami; Sadeghian, Nastaran; Mamedov, Sabir (Taylor & Francis LTD, 2017)1-(4-Methylsulfonyl)-2-thione-4-aryl-5-Z-6-methyl and oxyalkyl-imidazoles were synthesized from different tetrahydropyrimidinethiones and aryl sulfonyl chloride. These compunds were tested for metal chelating effects and ... -
Synthesis and biological evaluation of aminomethyl and alkoxymethyl derivatives as carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase inhibitors
Gülçin, İlhami; Abbasova, Malahat; Taslimi, Parham; Huyut, Zubeyir; Safarova, Leyla; Sujayev, Afsun; Supuran, Claudiu T. (Taylor & Francis LTD, 2017)Compounds containing nitrogen and sulfur atoms can be widely used in various fields such as industry, medicine, biotechnology and chemical technology. Therefore, the reactions of aminomethylation and alkoxymethylation of ... -
Tannic acid as a natural antioxidant compound: Discovery of a potent metabolic enzyme inhibitor for a new therapeutic approach in diabetes and Alzheimer's disease
Türkan, Fikret; Taslimi, Parham; Saltan, Fatma Zerrin (Wiley, 2019)Multiple studies have been recorded on the synthesis and design of multi-aim anti-Alzheimer molecules. Using dual butyrylcholinesterase/acetylcholinesterase inhibitor molecules has attracted more interest in the therapy ...