Yazar "Demir, Yeliz" için Eczacılık Fakültesi listeleme
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Anti-diabetic Properties of Calcium Channel Blockers: Inhibition Effects on Aldose Reductase Enzyme Activity
Türkeş, Cüneyt; Demir, Yeliz; Beydemir, Şükrü (Springer, 2019)Aldose reductase (AR) belongs to NADPH-dependent oxidoreductases and converts glucose to sorbitol in the polyol pathway. AR inhibition is essential to prevent diabetic complications. Here, AR was purified from sheep kidney ... -
Antidiabetic potential: In vitro inhibition effects of bromophenol and diarylmethanones derivatives on metabolic enzymes
Demir, Yeliz; Taslimi, Parham; Özaslan, Muhammet Serhat; Öztaşkın, Necla; Çetinkaya, Yasin; Gülçin, İlhami; Göksu, Süleyman (Wiley-V C H Verlag GMBH, 2018)Aldose reductase converts glucose to sorbitol in the polyol pathway. It is an important enzyme to prevent diabetic complications. In this study, we studied the inhibitory effects of bromophenol derivatives on aldose reductase ... -
Antiepileptic drugs: Impacts on human serum paraoxonase-1
Beydemir, Şükrü; Demir, Yeliz (Wiley, 2017)Serum paraoxonase (PON1) is a key enzyme related to high-density lipoprotein (HDL)-cholesterol particle. It can prevent the oxidation of low-density lipoprotein (LDL) and HDL. The present article focuses on the in vitro ... -
Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, alpha-amylase and alpha-glycosidase inhibitors as new therapeutic approach in diabetes and functional hyperglycemia
Taslimi, Parham; Aslan, Hatice Esra; Demir, Yeliz; Öztaşkın, Necla; Maras, Ahmet; Gülçin, İlhami; Göksu, Süleyman (Elsevier Science BV, 2018)Diabetes mellitus (DM) is a chronic metabolic disease in which there are high blood sugar levels over a prolonged period. Aldose reductase (AR) belongs to aldo-keto reductase superfamily and plays a key role in the polyol ... -
The effects of some cephalosporins on acetylcholinesterase and glutathione S-transferase: an in vivo and in vitro study
Türkan, Fikret; Huyut, Zubeyir; Demir, Yeliz; Ertaş, Fatma; Beydemir, Şükrü (Taylor & Francis LTD, 2019)Background: Glutathione S-transferase (GST) and acetylcholinesterase (AChE) are important enzymes in the metabolism. GSTs are primarily available in phase II metabolism. AChE is vital for neurodegenerative disorders. ... -
Evaluation of chalcones as inhibitors of glutathione S-transferase
Özaslan, Muhammet Serhat; Demir, Yeliz; Aslan, Hatice Esra; Beydemir, Şükrü; Kufrevioğlu, Ömer İrfan (Wiley, 2018)Glutathione S-transferases (GSTs) are the superfamily of multifunctional detoxification isoenzymes and play an important role in cellular signaling. In the present study, potential inhibition effects of chalcones were ... -
Inhibition effects of pesticides on glutathione-S-transferase enzyme activity of Van Lake fish liver
Özaslan, Muhamnnet Serhat; Demir, Yeliz; Aksoy, Mine; Kufrevioğlu, Ömer İrfan; Beydemir, Şükrü (Wiley, 2018)Glutathione-S-transferases (GSTs) have a function in xenobiotic metabolism. They are a significant multifunctional family with a wide variety of catalytic activities. In the current study, we determined in vitro inhibition ... -
Inhibition effects of quinones on aldose reductase: Antidiabetic properties
Demir, Yeliz; Özaslan, Muhammet Serhat; Duran, Hatice Esra; Kufrevioğlu, Ömer İrfan; Beydemir, Şükrü (Elsevier, 2019)Diabetes mellitus is a chronic metabolic disease characterized by abnormal glucose metabolism. Aldose reductase (AR) is the first enzyme in the polyol pathway and converts glucose to sorbitol. It plays a vital role as a ... -
Inhibitory Effects of Usnic and Carnosic Acid on Some Metabolic Enzymes: An in vitro Study
Ceylan, Hamid; Demir, Yeliz; Beydemir, Şükrü (Bentham Science Publ LTD, 2019)Background: Natural products arc produced via primary and secondary metabolism in different organisms. The compounds obtained via secondary metabolism are not essential for the survival of the organism, but they can have ... -
Koyun Karaciğerinden Alkol Dehidrogenaz: Saflaştırma, Karakterizasyon, ve Bazı Antibiyotiklerin Etkileri
Demir, Yeliz; Şengül, Bülent; Ergun, Bülent (2017)Alkol dehidrogenaz (ADH), her bir alt biriminin bir Zn2+ metal içeren katalitik alana ve bir kofaktör bağlama alanına sahip olduğu dimerik bir enzimdir. Bu enzim, alkolü, aldehide dönüştürür. Bu makale koyun karaciğerinden ... -
Phenolic compounds inhibit the aldose reductase enzyme from the sheep kidney
Demir, Yeliz; Işık, Mesut; Gülçin, İlhami; Beydemir, Şükrü (Wiley, 2017)Aldose reductase (AR) is the key enzyme for the polyol pathway and responsible for sorbitol accumulation during the hyperglycemia. The present article focuses on the role of phenol, pyrogallol, hydroquinone, resorcinol, ... -
Phytase from Weissella halotolerans: purification, partial characterisation and the effect of some metals
Demir, Yeliz; Kotan, Merve Şenol; Dikbas, Neslihan; Beydemir, Şükrü (Taylor & Francis Inc, 2017)In the study, phytase was purified in three simple steps comprising ammonium sulphate precipitation, anion exchange and gel filtration chromatography from Weissella halotolerans. The enzyme was obtained with a specific ... -
Purification and Biochemical Characterization of Phytase Enzyme from Lactobacillus coryniformis (MH121153)
Demir, Yeliz; Dikbas, Neslihan; Beydemir, Şükrü (Humana Press Inc, 2018)Phytase (myo-inositol hexaphosphate phosphohydrolase) belongs to phosphatases. It catalyzes the hydrolysis of phytate to less-phosphorylated inorganic phosphates and phytate. Phytase is used primarily for the feeding of ... -
Synthesis, biological evaluation and in silico studies of novel N-substituted phthalazine sulfonamide compounds as potent carbonic anhydrase and acetylcholinesterase inhibitors
Türkeş, Cüneyt; Arslan, Mustafa; Demir, Yeliz; Cocaj, Liridon; Nixha, Arleta Rıfati; Beydemir, Şükrü (Academic Press Inc Elsevier Science, 2019)The synthesis, characterization and biological evaluation of a series of novel N-substituted phthalazine sulfonamide (5a-1) are disclosed. Phthalazines which are nitrogen-containing heterocyclic compounds are biologically ...