A facile protocol for the preparation of 5-alkylidene and 5-imino substituted hydantoins from N,N '-disubstituted parabanic acids

Abstract

A convenient procedure for the preparation of various substituted (thio)hydantoins is described. The method is based on Wittig and aza-Wittig reactions of parabanic acids with phosphonium ylides. The reactions occurred both regio- and stereo-selectively