| dc.contributor.author | Sidir, İsa | |
| dc.contributor.author | Sidir, Yadigar Gülseven | |
| dc.contributor.author | Berber, Halil | |
| dc.date.accessioned | 2019-10-20T09:02:58Z | |
| dc.date.available | 2019-10-20T09:02:58Z | |
| dc.date.issued | 2013 | |
| dc.identifier.issn | 1386-1425 | |
| dc.identifier.uri | https://dx.doi.org/10.1016/j.saa.2013.03.071 | |
| dc.identifier.uri | https://hdl.handle.net/11421/16585 | |
| dc.description | WOS: 000320481700030 | en_US |
| dc.description | PubMed ID: 23644445 | en_US |
| dc.description.abstract | In this study, protonation and deprotonation behaviors of eight new drug precursor benzothiazolon derivatives in all of acidic and basic scale (super acidic, pH, super basic regions) are analyzed by using UV-visible spectrophotometric technique. Acidity constants (pK(a)), elucidation of the structure and protonation mechanisms of the studied molecules are obtained. Substituent effect on acidity constant values is discussed. These molecules are protonated from oxygen atom of acetamide group in the keto form. The protonation is found to be considerably contributed by the keto form | en_US |
| dc.description.sponsorship | Turkish Scientific Council (TUBITAK) [108T192]; Anadolu University, Faculty of Science, Department of Chemistry | en_US |
| dc.description.sponsorship | We are grateful to Turkish Scientific Council (TUBITAK) for the financial support to this work via the Research Project with the number of 108T192. We would like to thank Associated Professor Doctor Ahmet Cabuk and his PhD student Serap Gedikli for support with the UV-2550 Shimadzu UV-visible spectrophotometer. We would like to thanks Anadolu University, Faculty of Science, Department of Chemistry for support with CAChe 6.1. software. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Pergamon-Elsevier Science LTD | en_US |
| dc.relation.isversionof | 10.1016/j.saa.2013.03.071 | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Acidity Constant | en_US |
| dc.subject | Benzothiazolon Derivatives | en_US |
| dc.subject | Half-Protonation Value | en_US |
| dc.subject | Nsai Drug | en_US |
| dc.subject | Tautomerism | en_US |
| dc.title | Acidity constant determination of novel drug precursor benzothiazolon derivatives including acyl and piperazine moieties | en_US |
| dc.type | article | en_US |
| dc.relation.journal | Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy | en_US |
| dc.contributor.department | Anadolu Üniversitesi, Fen Fakültesi, Fizik Bölümü | en_US |
| dc.identifier.volume | 111 | en_US |
| dc.identifier.startpage | 211 | en_US |
| dc.identifier.endpage | 216 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.contributor.institutionauthor | Berber, Halil | |
