| dc.contributor.author | Koparal, Ayşe Tansu | |
| dc.date.accessioned | 2019-10-20T08:00:57Z | |
| dc.date.available | 2019-10-20T08:00:57Z | |
| dc.date.issued | 2015 | |
| dc.identifier.issn | 0939-5075 | |
| dc.identifier.issn | 1865-7125 | |
| dc.identifier.uri | https://dx.doi.org/10.1515/znc-2014-4178 | |
| dc.identifier.uri | https://hdl.handle.net/11421/16220 | |
| dc.description | WOS: 000359348000006 | en_US |
| dc.description | PubMed ID: 26136299 | en_US |
| dc.description.abstract | The anti-proliferative activities of the lichen substances (-)-usnic acid and vulpinic acid on the viability of HepG2 hepatocarcinoma cells, NS20Y neuroblastoma cells and HUVEC endothelial cells were studied by the MTT assay. The anti-angiogenic potential of the substances was determined by the endothelial tube formation assay. Both lichen substances exhibited strong anti-angiogenic activity and were more cytotoxic to the cancer cell lines than to the normal cell line, but vulpinic acid has more potential as an anti-angiogenic substance because of its low cytotoxicity and stronger anti-angiogenic activity on the HUVEC cell line. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Walter De Gruyter GMBH | en_US |
| dc.relation.isversionof | 10.1515/znc-2014-4178 | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Cladonia Foliacea | en_US |
| dc.subject | Letharia Vulpina | en_US |
| dc.subject | (-)-Usnic Acid | en_US |
| dc.subject | Vulpinic Acid | en_US |
| dc.title | Anti-angiogenic and antiproliferative properties of the lichen substances (-)-usnic acid and vulpinic acid | en_US |
| dc.type | article | en_US |
| dc.relation.journal | Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences | en_US |
| dc.contributor.department | Anadolu Üniversitesi, Fen Fakültesi, Biyoloji Bölümü | en_US |
| dc.identifier.volume | 70 | en_US |
| dc.identifier.issue | 5.Haz | en_US |
| dc.identifier.startpage | 159 | en_US |
| dc.identifier.endpage | 164 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.contributor.institutionauthor | Koparal, Ayşe Tansu | |
