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dc.contributor.authorVarol, Mehmet
dc.contributor.authorTürk, Ayşen Özdemir
dc.contributor.authorCandan, Mehmet
dc.contributor.authorTay, Turgay
dc.contributor.authorKoparal, Ayşe Tansu
dc.date.accessioned2019-10-20T08:00:46Z
dc.date.available2019-10-20T08:00:46Z
dc.date.issued2016
dc.identifier.issn0951-418X
dc.identifier.issn1099-1573
dc.identifier.urihttps://dx.doi.org/10.1002/ptr.5493
dc.identifier.urihttps://hdl.handle.net/11421/16174
dc.descriptionWOS: 000367919300002en_US
dc.descriptionPubMed ID: 26463741en_US
dc.description.abstractVulpinic and gyrophoric acids are known as ultraviolet filters for natural lichen populations because of their chemical structures. However, to the best of our knowledge, there has been no reference to their cosmetic potential for skin protection against ultraviolet B (UVB)-induced damage and, consequently, we propose to highlight their photoprotective profiles in human keratinocytes (HaCaT). Therefore, vulpinic acid and gyrophoric acid were isolated from acetone extracts of Letharia vulpina and Xanthoparmelia pokornyi, respectively. Their photoprotective activities on irradiated HaCaT cells and destructive effects on non-irradiated HaCaT cells were compared through in vitro experimentation: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and lactate dehydrogenase assays, 4,6-diamino-2-phenylindole and tetramethylrhodamine B isothiocyanate-phalloidin staining protocols. Both of the lichen substances effectively prevented cytotoxic, apoptotic and cytoskeleton alterative activities of 2.5J/cm(2) UVB in a dose-dependent manner. Moreover, vulpinic and gyrophoric acids showed no toxic, apoptotic or cytoskeleton alterative effects on non-irradiated HaCaT cells, except at high doses (400M) of gyrophoric acid. The findings suggest that vulpinic and gyrophoric acids can be promising cosmetic ingredients to photo-protect human skin cells and should therefore be further investigated by in vitro and in vivo multiple bioassays. Copyright (c) 2015 John Wiley & Sons, Ltd.en_US
dc.description.sponsorshipCommission of Scientific Research Projects of Anadolu University, Turkey [1106F116]en_US
dc.description.sponsorshipThis research was supported financially by the Commission of Scientific Research Projects of Anadolu University, Turkey (Project no: 1106F116) 'Liken asitlerinin ultraviyole isinlara karsi koruyucu etkisinin incelenmesi'.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/ptr.5493en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLichen Aciden_US
dc.subjectUltravioleten_US
dc.subjectPhotoprotectiveen_US
dc.subjectVulpinicen_US
dc.subjectGyrophoricen_US
dc.subjectActin Cytoskeletonen_US
dc.titlePhotoprotective Activity of Vulpinic and Gyrophoric Acids Toward Ultraviolet B-Induced Damage in Human Keratinocytesen_US
dc.typearticleen_US
dc.relation.journalPhytotherapy Researchen_US
dc.contributor.departmentAnadolu Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.identifier.volume30en_US
dc.identifier.issue1en_US
dc.identifier.startpage9en_US
dc.identifier.endpage15en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorTürk, Ayşen Özdemir
dc.contributor.institutionauthorCandan, Mehmet
dc.contributor.institutionauthorKoparal, Ayşe Tansu


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