Gelişmiş Arama

Basit öğe kaydını göster

dc.contributor.authorHanci, D.
dc.contributor.authorUlusoy, S.
dc.contributor.authorAcar, M.
dc.contributor.authorBurukoğlu, D.
dc.contributor.authorKutlu, Hatice Mehtap
dc.contributor.authorMuluk, Nuray Bayar
dc.contributor.authorCingi, Cemal
dc.date.accessioned2019-10-20T08:00:26Z
dc.date.available2019-10-20T08:00:26Z
dc.date.issued2016
dc.identifier.issn1128-3602
dc.identifier.urihttps://hdl.handle.net/11421/16071
dc.descriptionWOS: 000384168600022en_US
dc.descriptionPubMed ID: 27608909en_US
dc.description.abstractOBJECTIVE: To investigate the potential preventive effect of resveratrol in rats exposed to acoustic trauma (AT). MATERIALS AND METHODS: In this experimental study, Wistar albino rats were divided into three groups: Group 1 (Control, n = 6), Group 2 (AT, n = 6), and Group 3 (resveratrol + AT). The rats in Group 2 were exposed to AT. The rats in Group 3 received resveratrol (300 mg/kg/day) via gavage for 7 days. On day 7, the rats were exposed to AT 10 min following resveratrol treatment. Histological sections of the cochleae were examined using light microscopy, transmission (TEM), and scanning electron microscopy (SEM). RESULTS: The cochlear hair cells, stereocilia, and Deiters' cells of the control group appeared normal in all microscopic evaluations. In Group 2, light microscopy revealed predominantly inner hair cell loss, although the outer hair cells were affected. TEM and SEM examination showed severe loss of stereocilia and SEM revealed stereocilia arranged in an asymmetric array. The cochlear structure in Group 3 appeared well preserved under the light microscope, and although TEM and SEM revealed stereocilia loss, the hair cells and stereocilia appeared near normal compared with those of Group 2. CONCLUSIONS: Resveratrol may have a protective effect against AT damage in the cochlea, most likely through its antioxidant activity. Our results may be useful for studies in humans exposed to AT and noise-induced hearing loss related to chronic exposure to occupational noise.en_US
dc.description.sponsorshipContinuous Education and Scientific Research Associationen_US
dc.description.sponsorshipWith the exception of data collection, the preparation of this paper, including design and planning, was supported by the Continuous Education and Scientific Research Association. Only scientific support was provided; no grant or funding was received.en_US
dc.language.isoengen_US
dc.publisherVerduci Publisheren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectResveratrolen_US
dc.subjectAcoustic Traumaen_US
dc.subjectLight Microscopyen_US
dc.subjectTransmission Electron Microscopyen_US
dc.subjectScanning Electron Microscopyen_US
dc.titlePotential protective effect of resveratrol on acoustic trauma: electron microscopy studyen_US
dc.typearticleen_US
dc.relation.journalEuropean Review For Medical and Pharmacological Sciencesen_US
dc.contributor.departmentAnadolu Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.identifier.volume20en_US
dc.identifier.issue16en_US
dc.identifier.startpage3469en_US
dc.identifier.endpage3475en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorKutlu, Hatice Mehtap


Bu öğenin dosyaları:

Thumbnail

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster