| dc.contributor.author | Tabbı, Aouatef | |
| dc.contributor.author | Kaplancıklı, Zafer Asım | |
| dc.contributor.author | Tebbanı, Dahmane | |
| dc.contributor.author | Yurttaş, Leyla | |
| dc.contributor.author | Cantürk, Zerrin | |
| dc.contributor.author | Atlı Eklioğlu, Özlem | |
| dc.contributor.author | Turan, Gülhan | |
| dc.date.accessioned | 2019-10-19T16:02:35Z | |
| dc.date.available | 2019-10-19T16:02:35Z | |
| dc.date.issued | 2016 | |
| dc.identifier.issn | 1300-0527 | |
| dc.identifier.uri | http://www.trdizin.gov.tr/publication/paper/detail/TWpVMk1USTJOZz09 | |
| dc.identifier.uri | https://hdl.handle.net/11421/13819 | |
| dc.description.abstract | Several novel thiazolylpyrazoline derivatives were synthesized by reacting substituted 3,5-diaryl-1-thiocarba-moyl-2-pyrazolines with phenacylbromides. The structures of the synthesized compounds were con rmed by IR,1HNMR,13C NMR, and MS spectral data. Their antimicrobial activities againstStaphylococcus aureus(ATCC-25923),En-terococcus faecalis(ATCC-29212),Enterococcus faecalis(ATCC-51922),Listeria monocytogenes(ATCC-1911),Klebsiellapneumoniae(ATCC-700603),Pseudomonas aeruginosa(ATCC-27853),Escherichia coli(ATCC-35218),Escherichia coli(ATCC-25922),Candida albicans(ATCC-90028),Candida glabrata(ATCC-90030),Candida krusei(ATCC-6258), andCandida parapsilosis(ATCC-22019) were investigated. The compounds were also studied for their cytotoxic effects usinga MTT assay. Compound7cshowed the highest antimicrobial activity, possessing the same potential as chloramphenicolagainstK. pneumonia,P. aeruginosa, andE. coli(ATCC-25923). | en_US |
| dc.description.abstract | Several novel thiazolylpyrazoline derivatives were synthesized by reacting substituted 3,5-diaryl-1-thiocarba-moyl-2-pyrazolines with phenacylbromides. The structures of the synthesized compounds were con rmed by IR,1HNMR,13C NMR, and MS spectral data. Their antimicrobial activities againstStaphylococcus aureus(ATCC-25923),En-terococcus faecalis(ATCC-29212),Enterococcus faecalis(ATCC-51922),Listeria monocytogenes(ATCC-1911),Klebsiellapneumoniae(ATCC-700603),Pseudomonas aeruginosa(ATCC-27853),Escherichia coli(ATCC-35218),Escherichia coli(ATCC-25922),Candida albicans(ATCC-90028),Candida glabrata(ATCC-90030),Candida krusei(ATCC-6258), andCandida parapsilosis(ATCC-22019) were investigated. The compounds were also studied for their cytotoxic effects usinga MTT assay. Compound7cshowed the highest antimicrobial activity, possessing the same potential as chloramphenicolagainstK. pneumonia,P. aeruginosa, andE. coli(ATCC-25923). | en_US |
| dc.language.iso | eng | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Mühendislik | en_US |
| dc.subject | Kimya | en_US |
| dc.title | Synthesis of novel thiazolylpyrazoline derivatives and evaluation of theirantimicrobial activities and cytotoxicities | en_US |
| dc.type | article | en_US |
| dc.relation.journal | Turkish Journal of Chemistry | en_US |
| dc.contributor.department | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı | en_US |
| dc.identifier.volume | 40 | en_US |
| dc.identifier.issue | 4 | en_US |
| dc.identifier.startpage | 641 | en_US |
| dc.identifier.endpage | 654 | en_US |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US] |
| dc.contributor.institutionauthor | Kaplancıklı, Zafer Asım | |
| dc.contributor.institutionauthor | Yurttaş, Leyla | |
| dc.contributor.institutionauthor | Atlı Eklioğlu, Özlem | |
| dc.contributor.institutionauthor | Turan, Gülhan | |
