| dc.contributor.author | Beynek, Nesrin | |
| dc.contributor.author | Uluçam, Gühergül | |
| dc.contributor.author | Benkli, Kadriye | |
| dc.date.accessioned | 2019-10-19T16:02:33Z | |
| dc.date.available | 2019-10-19T16:02:33Z | |
| dc.date.issued | 2009 | |
| dc.identifier.issn | 0340-4285 | |
| dc.identifier.uri | https://dx.doi.org/10.1007/s11243-009-9192-1 | |
| dc.identifier.uri | https://hdl.handle.net/11421/13788 | |
| dc.description.abstract | A binaphthyl-linked bipyridyl compound, 1,1?-bis(6-methyl-6?-oxymethylenyl- 2,2?-bipyridine)binaphthyl, (L) has been synthesised and used as a ligand for the formation of Cu(II), Ni(II), and Co(II) complexes. The ligand and its transition-metal complexes were characterized by physico-chemical and spectroscopic methods. The complexes were also investigated for cytotoxic activity. The cytotoxicity of complexes, CuL(ClO4)2, NiL(ClO4)2(H2O), CoL(ClO4) 2, were tested in vitro applying seven well-characterized human tumor cell lines, MCF7, EVSA-T, WIDR, IGROV, M19 MEL, A498, H226, and the microculture sulforhodamine B (SRB) test. All complexes show a very high cytotoxicity (ID50 > 250 ng/ml) in these cell lines | en_US |
| dc.description.sponsorship | Acknowledgments The authors thank Trakya University and Anadolu University, Commissions of Scientific Research Projects and gratefully acknowledge Leiden University for the experimental and theoretical support of this work and for discussions (G.A. van Albada and J. Reedijk). The authors also thank Pharmachemie BV Netherlands, for performing the anticancer tests and recording API-ES mass spectrum and EPR of complexes. | en_US |
| dc.language.iso | eng | en_US |
| dc.relation.isversionof | 10.1007/s11243-009-9192-1 | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.title | Synthesis and cytotoxic activities of transition-metal complexes of a binaphthyl-linked bipyridine ligand | en_US |
| dc.type | article | en_US |
| dc.relation.journal | Transition Metal Chemistry | en_US |
| dc.contributor.department | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı | en_US |
| dc.identifier.volume | 34 | en_US |
| dc.identifier.issue | 3 | en_US |
| dc.identifier.startpage | 289 | en_US |
| dc.identifier.endpage | 292 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US] |
| dc.contributor.institutionauthor | Benkli, Kadriye | |
