• Reproductive toxic effects and possible mechanisms of zonisamide in male rats 

  Karaduman, A. B.; Kılıç, Volkan; Atli-Eklioğlu, O.; Baysal, Merve; Aydoğan Kılıç, Gözde; Ucarcan, S.; Ilgın, Sinem (SAGE Publications Ltd, 2019)

  Zonisamide (ZNS) is an anticonvulsant which is used to treat the symptoms of epilepsy. Although it is frequently used during reproductive ages, studies that investigated the effects of ZNS on reproductive system are limited. ...

• Acute drug poisonings in Eskisehir, Turkey: A retrospective study 

  Ergün, Bülent; Çevik, Alper Arif; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Saraçoğlu, Ahmet; Acar, Nurdan (2013)

  Bu çalışmada ESOGU Tıp Fakültesi Hastanesi Yetişkin Acil Servisine Ocak 2003 - Aralık 2009 yılları arasında başvuran akut ilaç zehirlenme olgularının retrospektif olarak değerlendirilmesi amaçlanmaktadır. Bu amaçla olgulara ...

• Effects of sildenafil citrate administration on cardiovascular system of subchronic fluoxetine HCI treated male rats 

  Saraçoğlu, Ahmet; Ergün, Bülent; Uzuner, Kubilay (2005)

  Amaç: Sildenafil sitrat fluoksetin HCl tedavisine bağlı olarak gelişen erektil disfonksiyon tedavisinde sıklıkla kullanılan bir ilaçtır. Fluoksetin HCl sildenafil metabolizmasında rol oynayan P450 CYP3A4 ve CYP2C enzimlerini ...

• Studies on controlled release dimenhydrinate from matrix tablet formulations 

  Genç, Lütfi; Bilaç, H.; Güler, E. (1999)

  In this study, controlled release dosage forms of dimenhydrinate were prepared with different polymers as MC, HEC, Carbopol 934, Eudragit RLPM and Eudragit NE 30 D at different concentrations (2.5-10%). Direct compression ...

• Effects of sildenafil citrate administration on cardiovascular system of subchronic fluoxetine HCl treated male rats 

  Saraçoğlu, Ahmet; Ergün, Bülent; Uzuner, K.; Aydın, Y. (Turkiye Klinikleri, 2005)

  Objective: Sildenafil citrate is a commonly used drug for the treatment of erectile dysfunction accompanied with fluoxetine HCl treatment. Fluoxitine HCl inhibits the cytochrome P450 CYP3A4 and CYP2C enzymes which are the ...

• Acute drug poisonings in Eskisehir, Turkey: A retrospective study [Eskişehirde akut i·laç zehirlenmeleri: Retrospektif bir çahşma] 

  Ergün, Bülent; Çevik, Alper Arif; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Saraçoğlu, Ahmet; Acar, N.; Uzuncakara, D. (2013)

  The aim of this study was to characterize acute drug-poisoning cases admitted to the Adult Emergency Service of ESOGU Medicine Faculty Hospital, Turkey. All acute drug-poisoning cases admitted to the emergency service from ...

• Insulin neuropathy: Rare adverse effect of insulin therapy 

  Ergün, Bülent (Ibn Sina Trust, 2016)

  Insulin neuropathy is a rare adverse effect of insulin therapy in patients with long-term uncontrolled hyperglycemia. Neuropathic pain appears after the correction of blood glucose level. A 34 years old woman with severe ...

• Validated reversed phase HPLC method for the analysis of the food additive, sodium benzoate, in soft drinks and jams 

  Altıokka, Göksel; Ergün, Bülent; Can, Nafiz Öncü; Aboul-Enein, Hassan Y. (Taylor & Francis Inc, 2007)

  A rapid, simple, and sensitive method is described for the determination of the food preservative sodium benzoate in soft drinks, various jams, and ketchup. The method utilizes high performance liquid chromatography followed ...

• Evaluation of the reproductive toxicity of naproxen sodium and meloxicam in male rats 

  Uzun, B.; Atlı Eklioğlu, Özlem; Perk, B. O.; Burukoğlu, D.; Ilgın, Sinem (SAGE Publications LTD, 2015)

  Nonsteroidal anti-inflammatory drugs that are cyclooxygenase (COX) enzyme inhibitors have generally been used in short-term pain management and also to treat inflammation chronically. It is known that COX enzyme and ...

• Cardioprotection with resveratrol pretreatment: improved beneficial effects over standard treatment in rat hearts after global ischemia 

  Dernek, S; İkizler, M; Erkasap, Nilüfer; Ergün, B; Köken, T; Yılmaz, K; Kural, T (Taylor & Francis LTD, 2004)

  Objective-The major objective of the present study is to evaluate the potential role of resveratrol (RVT), a natural antioxidant found in grapes and red wine, in protecting the myocardium from the deleterious effects of ...

• Oxidative stress-mediated myrocardiotoxicity of ciprofloxacin and ofloxacin in juvenile rats 

  Saraçoğlu, Ahmet; Temel, Halide Edip; Ergün, Bülent; Çolak, Ömer (Taylor & Francis Inc, 2009)

  In this study, evaluation of the myocardiotoxic effect potential of ciprofloxacin and ofloxacin in juvenile rats and the role of oxidative stress in heart toxicity was conducted. Doses (25 and 50 mg/kg) of each drug were ...

• Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors 

  Ilgın, Sinem; Osmaniye, Derya; Levent, Serkan; Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Kaya Çavuşoğlu, Betül; Kaplancıklı, Zafer Asım (MDPI AG, 2017)

  In the current work a new class of novel benzothiazole-hydrazone derivatives was designed and synthesized as hMAO-B inhibitors. Structures of the obtained compounds (3a-3j) were characterized by IR, 1H-NMR, 13C-NMR, and ...

• Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress 

  Ilgın, Sinem; Aydoğan-Kılıç, Gözde; Baysal, Merve; Kılıç, Volkan; Ardıç, Mina; Uçarcan, Şeyda; Atlı Eklioğlu, Özlem (Hindawi LTD, 2018)

  Depression and anxiety are recognized as public health problems. Epidemiological studies have shown that depression and anxiety often occur during reproductive ages between 20 and 60 years of age in males. Trazodone is one ...

• Evidence for cardiotoxicity associated with sertraline in rats 

  Ilgın, Sinem; Kılıç, Volkan; Baysal, Merve; Aydoğan Kılıç, Gözde; Uçarcan, Şeyda; Dermenci, Begüm; Atlı Eklioğlu, Özlem (Royal Soc Chemistry, 2018)

  Sertraline is an antidepressant that is frequently prescribed to treat depression, obsessive-compulsive disorder, panic disorder, and anxiety. This drug had a safe cardiotoxicity profile, until the reporting of cases of ...

• Citalopram Induces Reproductive Toxicity in Male Rats 

  Ilgın, Sinem; Aydoğan-Kılıc, G.; Baysal, Merve; Kılıç, Volkan; Korkut, Büşra; Uçarcan, Şeyda; Atlı Eklioğlu, Özlem (Wiley, 2017)

  Background: Citalopram hydrobromide (CTL) has been shown to cause sexual dysfunction; however, its reproductive toxicity potential has not been sufficiently elucidated in men. Therefore, we aimed to clarify the toxic effects ...

• Acute and Subchronic Toxic Effects of the Fruits of Physalis peruviana L. 

  Perk, Başak Özlem; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Duymuş, Hale Gamze; Sırmagül, Başar (Hindawi Publishing Corporation, 2013)

  The fruit of Physalis peruviana L. (PPL) has been traditionally used as antispasmodic, diuretic, antiseptic, sedative, and analgesic all over the world. We aimed to perform qualitative content analysis of the fruits of PPL ...

• Ciprofloxacin-induced neurotoxicity: evaluation of possible underlying mechanisms 

  Ilgın, Sinem; Can, Özgür Devrim; Atlı Eklioğlu, Özlem; Ucel, Umut İrfan; Şener, Erol; Güven, İlkay (Taylor & Francis LTD, 2015)

  Ciprofloxacin (CPX) is a fluoroquinolone antibiotic used for treating respiratory, urinary tract, gastrointestinal and abdominal infections. There are only a limited number of studies related to neurological adverse effects ...

• Insulin Neuropathy: Rare Adverse Effect of Insulin Therapy 

  Ergün, Bülent (Ibn Sina Trust, 2016)

  Insulin neuropathy is a rare adverse effect of insulin therapy in patients with long-term uncontrolled hyperglycemia. Neuropathic pain appears after the correction of blood glucose level. A 34 years old woman with severe ...

• Determination of Phenolic Compounds of Stachys Rupestris Montbret Et Aucher Ex Bentham By Lc-Ms/Ms and Its Biological Activities 

  Ergün, Bülent; Göğer, Fatih; Köse, Yavuz Bülent; İşcan, Gökalp (Parlar Scientific Publications (PSP), 2018)

  One of the largest genus of Lamiaceae, Stachys, extended from south western part of Asia to America, represented in Turkey with % 48 endemism rate. In this presented study LC-ESI-MS/MS properties, anticandidal, antioxidant ...

• Evaluation of antimicrobial, Cytotoxic and genotoxic activities of Ganoderma lucidum (Reishi mushroom) 

  Ergün, Bülent (University Karachi, 2017)

  Ganoderma lucidum (GL) is a mushroom used as a traditional remedy for the treatment of various infections since ancient times. This study, was aimed to investigate antimicrobial activity potential of GL against Staphylococcus ...

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