| dc.contributor.author | Demirayak, Şeref | |
| dc.contributor.author | Yurttaş, Leyla | |
| dc.contributor.author | Karaburun, Ahmet Çağrı | |
| dc.contributor.author | Gündoğdu-Karaburun, Nalan | |
| dc.contributor.author | Kayagil, İsmail | |
| dc.date.accessioned | 2019-10-19T14:44:56Z | |
| dc.date.available | 2019-10-19T14:44:56Z | |
| dc.date.issued | 2016 | |
| dc.identifier.issn | 1570-1808 | |
| dc.identifier.issn | 1875-628X | |
| dc.identifier.uri | https://dx.doi.org/10.2174/1570180813999160429113316 | |
| dc.identifier.uri | https://hdl.handle.net/11421/13645 | |
| dc.description | WOS: 000389460600011 | en_US |
| dc.description.abstract | The synthesis of 2-arylidene 6-(2-aryl-2-oxoethoxy) benzofuran-3-one derivatives was reported and selected compounds were determined for their anticancer activity evaluation in National Cancer Institute NCI, USA according to the drug screening protocol of the institute against approximately 60 tumor cell lines derived from nine cancer diseases. Compound 3r, namely 2-(4-chlorobenzylidene)- 6-[2-(4-methoxyphenyl)-2-oxoethoxy] benzofuran-3-one exhibited the highest antitumor activity against non-small lung cancer cell lines. | en_US |
| dc.description.sponsorship | Anadolu University, Turkey (BAP Project) [050301] | en_US |
| dc.description.sponsorship | The study was financially supported by Anadolu University, Turkey (BAP Project No: 050301). The authors present their thanks to NCI (USA) and Anadolu University BIBAM (Turkiye) for anticancer test results and NMR spectra, respectively. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Bentham Science Publ LTD | en_US |
| dc.relation.isversionof | 10.2174/1570180813999160429113316 | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Antitumor Activity | en_US |
| dc.subject | Aurone | en_US |
| dc.subject | Benzofuranone | en_US |
| dc.subject | Chalcone | en_US |
| dc.subject | Cytotoxic Activity | en_US |
| dc.title | Synthesis and Antiproliferative Activity of 2-arylidene 6-(2-aryl-2-oxoethoxy) Benzofuran-3-one Derivatives | en_US |
| dc.type | article | en_US |
| dc.relation.journal | Letters in Drug Design & Discovery | en_US |
| dc.contributor.department | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı | en_US |
| dc.identifier.volume | 13 | en_US |
| dc.identifier.issue | 6 | en_US |
| dc.identifier.startpage | 563 | en_US |
| dc.identifier.endpage | 569 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.contributor.institutionauthor | Demirayak, Şeref | |
| dc.contributor.institutionauthor | Yurttaş, Leyla | |
| dc.contributor.institutionauthor | Karaburun, Ahmet Çağrı | |
| dc.contributor.institutionauthor | Gündoğdu-Karaburun, Nalan | |
