dc.contributor.author | Yurttaş, Leyla | |
dc.contributor.author | Kaplancıklı, Zafer Asım | |
dc.contributor.author | Cantürk, Zerrin | |
dc.contributor.author | Karaca Gencer, Hülya | |
dc.date.accessioned | 2019-10-19T14:44:55Z | |
dc.date.available | 2019-10-19T14:44:55Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1042-6507 | |
dc.identifier.issn | 1563-5325 | |
dc.identifier.uri | https://dx.doi.org/10.1080/10426507.2014.979984 | |
dc.identifier.uri | https://hdl.handle.net/11421/13643 | |
dc.description | WOS: 000359618400023 | en_US |
dc.description.abstract | A series of N'-(arylidene)-4-[(pyrimidine-2-yl)thio]butanohydrazide derivatives (3a-3m) has been synthesized and investigated for their antituberculotic and cytotoxic activity. The antitubercular activities of the newly synthesized compounds were tested against Mycobacterium tuberculosis H37Rv strain by MABA (Microplate Alamar Blue Assay) method and cytotoxic properties were tested against NIH/3T3 and A549 cell lines by MTT method. The title compounds have been exhibited moderate antitubercular activity. Compound 3m, titled N'-(4-nitrobenzylidene)-4-[(pyrimidine-2-yl)thio]butanohydrazide showed promising cytotoxic activity when compared with the standard drug. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis LTD | en_US |
dc.relation.isversionof | 10.1080/10426507.2014.979984 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Pyrimidine | en_US |
dc.subject | Hydrazone | en_US |
dc.subject | Alkylsulfanyl | en_US |
dc.subject | Antituberculotic | en_US |
dc.subject | Cytotoxic | en_US |
dc.title | Synthesis, Antituberculotic, and Cytotoxic Properties of New Hydrazone Derivatives Bearing Pyrimidine-Alkylsulfanyl Moiety | en_US |
dc.type | article | en_US |
dc.relation.journal | Phosphorus Sulfur and Silicon and the Related Elements | en_US |
dc.contributor.department | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı | en_US |
dc.identifier.volume | 190 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.startpage | 1183 | en_US |
dc.identifier.endpage | 1191 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.contributor.institutionauthor | Yurttaş, Leyla | |
dc.contributor.institutionauthor | Kaplancıklı, Zafer Asım | |
dc.contributor.institutionauthor | Cantürk, Zerrin | |
dc.contributor.institutionauthor | Karaca Gencer, Hülya | |