dc.contributor.author | Özdemir, Ahmet | |
dc.contributor.author | Altıntop, Mehlika Dilek | |
dc.contributor.author | Kaplancıklı, Zafer Asım | |
dc.contributor.author | Turan, Gülhan | |
dc.contributor.author | Çiftçi, Gülsen Akalın | |
dc.contributor.author | Demirci, Fatih | |
dc.date.accessioned | 2019-10-19T14:44:38Z | |
dc.date.available | 2019-10-19T14:44:38Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0091-150X | |
dc.identifier.issn | 1573-9031 | |
dc.identifier.uri | https://dx.doi.org/10.1007/s11094-014-1158-8 | |
dc.identifier.uri | https://hdl.handle.net/11421/13571 | |
dc.description | WOS: 000346900000007 | en_US |
dc.description.abstract | New pyrazoline derivatives bearing an oxadiazole moiety were synthesized via the reaction of 1-(chloroacetyl)-3-(2-furyl/thienyl)-5-aryl-2-pyrazolines with 5-substituted-1,3,4-oxadiazole-2(3H)-thiones in the presence of potassium carbonate. Compounds 1 - 32 were screened for their antifungal activity against various Candida species and compared with ketoconazole. Among these compounds, the most effective derivatives were evaluated for their cytotoxicity against NIH/3T3 cells. 2-({2-[5-(4-Bromophenyl)-3-(2-furyl)-4,5-dihydro-1H-pyrazol-1-yl]-2-oxoethyl}thio)-5-(2-cyclopentylethyl)-1,3,4-oxadiazole (23) can be identified as the most potent antifungal agent against C. tropicalis due to its inhibitory effect on C. tropicalis and low toxicity to NIH/3T3 cells. | en_US |
dc.description.sponsorship | Anadolu University Scientific Research Projects Commission [1001S41] | en_US |
dc.description.sponsorship | This study was supported by Anadolu University Scientific Research Projects Commission under the grant no. 1001S41. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.relation.isversionof | 10.1007/s11094-014-1158-8 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Anticandidal Activity | en_US |
dc.subject | Cytotoxicity | en_US |
dc.subject | Oxadiazole | en_US |
dc.subject | Pyrazoline | en_US |
dc.title | Synthesis and Biological Evaluation of a New Series of Pyrazolines as New Anticandidal Agents | en_US |
dc.type | article | en_US |
dc.relation.journal | Pharmaceutical Chemistry Journal | en_US |
dc.contributor.department | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı | en_US |
dc.identifier.volume | 48 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.startpage | 603 | en_US |
dc.identifier.endpage | 612 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.contributor.institutionauthor | Özdemir, Ahmet | |
dc.contributor.institutionauthor | Altıntop, Mehlika Dilek | |
dc.contributor.institutionauthor | Kaplancıklı, Zafer Asım | |
dc.contributor.institutionauthor | Turan, Gülhan | |
dc.contributor.institutionauthor | Çiftçi, Gülsen Akalın | |
dc.contributor.institutionauthor | Demirci, Fatih | |