| dc.contributor.author | Işıkdağ, İlhan | |
| dc.contributor.author | Özkay, Yusuf | |
| dc.contributor.author | İncesu, Zerrin | |
| dc.contributor.author | Akalın Çiftçi, Gülsen | |
| dc.date.accessioned | 2019-10-19T14:44:26Z | |
| dc.date.available | 2019-10-19T14:44:26Z | |
| dc.date.issued | 2011 | |
| dc.identifier.issn | 0939-5075 | |
| dc.identifier.uri | https://hdl.handle.net/11421/13518 | |
| dc.description | WOS: 000297960200005 | en_US |
| dc.description | PubMed ID: 22191211 | en_US |
| dc.description.abstract | The discovery of DNA topoisomerases has added a new dimension to the study of anticancer drugs. Bishenzimidazole derivatives are important compounds known as DNA topoisomerase 1 inhibitors. In the present study, some symmetrical bisbenzimidazole derivatives were synthesized and investigated for their anticancer activity. Anticancer activity screening was applied on HT-29 (colon carcinoma) and MCF-7 (breast carcinoma) cell lines by investigation of cytotoxicity, analysis of DNA synthesis, and DNA fragmentation assays. One of the seven compounds tested showed significant cytotoxicity in both cell lines and caused DNA degradation in the HT-29 cell line. | en_US |
| dc.description.sponsorship | Anadolu University Scientific Research Projects Commission [060316] | en_US |
| dc.description.sponsorship | This work was financially supported by Anadolu University Scientific Research Projects Commission (Project No. 060316) | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Verlag Z Naturforsch | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Bisbenzimidazole | en_US |
| dc.subject | Anticancer | en_US |
| dc.subject | Dna Topoisomerase | en_US |
| dc.title | Anticancer Activity of Some Bisbenzimidazoles | en_US |
| dc.type | article | en_US |
| dc.relation.journal | Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences | en_US |
| dc.contributor.department | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı | en_US |
| dc.identifier.volume | 66 | en_US |
| dc.identifier.issue | 9.Eki | en_US |
| dc.identifier.startpage | 465 | en_US |
| dc.identifier.endpage | 470 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.contributor.institutionauthor | Özkay, Yusuf | |
| dc.contributor.institutionauthor | Seller, Zerrin | |
| dc.contributor.institutionauthor | Akalın Çiftçi, Gülsen | |
