Spectroscopic Determination and Evaluation of Acidity Constants for Some Drug Precursor 2-Amino-4-(3-or 4-substituted phenyl) Thiazole Derivatives

Abstract

Acid dissociation constants, K(a), of eight drug precursor 2-amino-4-(3- or 4-substituted phenyl) thiazole derivatives were determined using a UV-vis spectroscopic technique. The obtained K(a) values were evaluated by Structure elucidation and a protonation mechanism. The obtained tautomerization equilibrium constants, K(T), indicated the predominance of amino forms for all studied compounds.