| dc.contributor.author | Akgün, H. | |
| dc.contributor.author | Balkan, A. | |
| dc.contributor.author | Erol, Kevser | |
| dc.contributor.author | Batu, Ö. S. | |
| dc.date.accessioned | 2019-10-19T14:43:55Z | |
| dc.date.available | 2019-10-19T14:43:55Z | |
| dc.date.issued | 1998 | |
| dc.identifier.issn | 0004-4172 | |
| dc.identifier.uri | https://hdl.handle.net/11421/13288 | |
| dc.description | PubMed: 9689423 | en_US |
| dc.description.abstract | Ten new compounds having 7-[(2,4-pentanedione-3-yl)alkyl]- and 7-[(3,5- dimethylisoxazole-4-yl)alkyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione structures were synthesized and their bronchodilator activities investigated using the method based on inhibition of acetylcholine and histamine-induced contractions in guinea pig trachea. None of the compounds were effective on acetylcholine-induced contractions. However, the compounds 4d, 4e, 5d and 5c were potent inhibitors of the bronchospasm induced by histamine, whereas the others (4b, 4c, 5b and 5c) were weak inhibitors. | en_US |
| dc.language.iso | eng | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | 2,4- Pentanediones | en_US |
| dc.subject | 3,5-Dimethylisoxazoles | en_US |
| dc.subject | Antiasthmatic Drugs | en_US |
| dc.subject | Antihistaminic Drugs | en_US |
| dc.subject | Theophylline, Bronchodilator Activity | en_US |
| dc.subject | Xanthine Derivatives | en_US |
| dc.title | New ß-diketone and 3,5-dimethyl isoxazole derivatives of theophylline as potential bronchodilator agents | en_US |
| dc.type | article | en_US |
| dc.relation.journal | Arzneimittel-Forschung/Drug Research | en_US |
| dc.contributor.department | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalı | en_US |
| dc.identifier.volume | 48 | en_US |
| dc.identifier.issue | 6 | en_US |
| dc.identifier.startpage | 658 | en_US |
| dc.identifier.endpage | 662 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
