Güncel Gönderiler: Makale Koleksiyonu
Toplam kayıt 317, listelenen: 181-200
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Synthesis and antimicrobial activity of new 2-((1-furan-2-yl)ethylidene)hydrazono)-4-phenylthiazol-3(2H)-amine derivatives and their schiff bases with 4-nitrobenzaldehyde
(Taylor & Francis LTD, 2018)A new series of 2-((1-furan-2-yl)ethylidene)hydrazono)-4-substitutedphenylthiazol-3(2H)-amines (2a-2o) and their Schiff bases (3a-3o) from 4-nitrobenzaldehyde were synthesized. The chemical structures of all the synthesized ... -
Design, synthesis and in vitro evaluation of new thiosemicarbazone derivatives as potential anticancer agents
(Marmara University, 2019)Thiosemicarbazones play a pivotal role as potential therapeutic agents for the management of lung cancer. 4-(4-Cyanophenyl)-1-[(5-arylfuran-2-yl)methylene]thiosemicarbazides (1-10) were obtained via the reaction of ... -
In silico Molecular Docking and ADME Studies of 1 3,4-Thiadiazole Derivatives in Relation to in vitro PON1 Activity
(Bentham Science Publ LTD, 2019)Background: Paraoxonase 1 (PON1) is a paraoxonase, arylesterase and lactonase associated with protection of lipoproteins and cell membranes against oxidative modification. Objective: Based on antioxidative properties of ... -
Biological evaluation of a series of benzothiazole derivatives as mosquitocidal agents
(Sciendo, 2019)Aedes aegypti is associated with the transmission of numerous human and animal diseases, such as yellow fever, dengue fever, chikungunya, and more recently Zika virus. Emerging insecticide resistance has created a need to ... -
Synthesis of New Thiazolyl-pyrazoline Derivatives and Evaluation of Their Antimicrobial, Cytotoxic and Genotoxic Effects
(Bentham Science Publ LTD, 2018)Background: Pyrazolines have played a pivotal role in antimicrobial and anticancer drug discovery. Moreover, thiazoles have attracted a great deal of interest due to their crucial roles in the lead identification and ... -
Indomethacin based new triazolothiadiazine derivatives: Synthesis, evaluation of their anticancer effects on T98 human glioma cell line related to COX-2 inhibition and docking studies
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)In the current work, new 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine derivatives (1-8) were synthesized via the ring closure reaction of 2-bromoacetophenone derivatives with 4-amino-5-[(5-methoxy-2-methyl-1(4-chlorobenzoyl)- ... -
Ethnobotany of Eskisehir and Its Environs
(Pakistan Botanical Soc, 2013)Eskisehir is located in the Central Anatolian province of Turkey. It is included in B3 grid square of Davis. There are more than 1000 plant taxa distributed in this State and its environs and nearly 220 are endemics. The ... -
Synthesis and biological evaluation of new pyrazolone Schiff bases as monoamine oxidase and cholinesterase inhibitors
(Academic Press Inc Elsevier Science, 2019)In the current work, Schiff base derivatives of antipyrine were synthesized. The chemical characterization of the compounds was confirmed using IR, H-1 NMR, C-13 NMR and mass spectroscopies. The inhibitory potency of ... -
Synthesis of new donepezil analogues and investigation of their effects on cholinesterase enzymes
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)Donepezil (DNP), an acetylcholinesterase (AChE) inhibitor, is one of the most preferred choices in Alzheimer diseases (AD) therapy. In the present study, 38 new DNP analogues were synthesized. Structures of the synthesized ... -
In vitro and in silico evaluation of new thiazole compounds as monoamine oxidase inhibitors
(Academic Press Inc Elsevier Science, 2019)New twenty compounds bearing thiazole ring (3a-3t) were designed and synthesized as monoamine oxidase (MAO) inhibitors. The fluorometric enzyme inhibition assay was used to determine the biological effects of synthesized ... -
Synthesis and Biological Evaluation of Some Novel Dithiocarbamate Derivatives
(Hindawi LTD, 2014)18 novel dithiocarbamate derivatives were synthesized in order to investigate their inhibitory potency on acetylcholinesterase enzyme and antimicrobial activity. Structures of the synthesized compounds were elucidated by ... -
Antimicrobial activity and a SAR study of some novel benzimidazole derivatives bearing hydrazone moiety
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)In this study 12 novel benzimidazole compounds bearing hydrazone moiety were synthesized in order to investigate their possible antibacterial and antifungal activity. Structures of the synthesized compounds were elucidated ... -
Synthesis and antiproliferative activity evaluation of new thiazole-benzimidazole derivatives using real-time cell analysis (RTCA DP)
(Springer Birkhauser, 2016)A series of new 2-[(5-substituted-1H-benzimidazol-2-yl)thio]-N-[4-[2-phenylthiazol-4-yl]phenyl]acetamide derivatives (4a-p) were synthesized according to the reported literature, and anticancer activity of the compounds ... -
Synthesis of new piperazine compounds and investigation of their anticholinesterase effects
(Çukurova University, Fac Medicine, 2017)Purpose: The aim of present study is to evaluate anticholinesterase activities of some new piperazine compounds. Materials and Methods: Ten new piperazine derivatives were synthesized. Structure elucidation of the synthesized ... -
Antimicrobial Activity of a New Series of Benzimidazole Derivatives
(Pharmaceutical Soc Korea, 2011)Due to antimicrobial importance of benzimidazoles and hydrazones, some benzimidazole-hydrazone compounds were synthesized to screen their antimicrobial activity. Structures of the synthesized compounds were elucidated by ... -
Antimicrobial Activity of a New Combination System of Benzimidazole and Various Azoles
(Wiley-Blackwell, 2011)In the present study a new series of benzimidazole derivatives bearing various (benz)azolylthio moieties were synthesized so as to investigate their antimicrobial activity. Structures of the target compounds (5a-5i) were ... -
Antiproliferative effects of some N-benzylideneanilines
(John Wiley & Sons LTD, 2008)A series of Schiff bases including N-benzylideneaniline (NBA) nuclei were prepared. The chemical products obtained were characterized by mass spectometry (APCI), H-1 NMR, and IR spectroscopy in order to seek their cytotoxic ... -
Synthesis of 2-substituted-N-[4-(1-methyl-4,5-diphenyl-1H-imidazole-2-yl) phenyl]acetamide derivatives and evaluation of their anticancer activity
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)In the present study 18 novel imidazole-(benz)azole and imidazole-piperazine derivatives were synthesized in order to investigate their probable anticancer activity. The structures of the compounds were confirmed by IR, ... -
Studies on hydrazone derivatives as antifungal agents
(Taylor & Francis LTD, 2008)The increasing clinical importance of drug-resistant fungal pathogens has urged additional need to fungal research and new antifungal compound development. For this purpose, some N-(1-benzyl-2-phenylethylidene)-N'-[4-(ar ... -
Synthesis and Antimicrobial Activity of Some Novel Benzimidazole Hydrazides
(Asian Journal Of Chemistry, 2011)The present study was undertaken to synthesize some 4-(5,6-dichloro-1H-benzimidazole-2-yl)phenoxyacetic acid-4-substituted benzylidene hydrazide derivatives and investigate their possible antimicrobial activity. Chemical ...
