Güncel Gönderiler: Farmasötik Kimya Anabilim Dalı
Toplam kayıt 345, listelenen: 241-260
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Synthesis and AChE Inhibitory Activity of Novel Thiazolylhydrazone Derivatives
(MDPI, 2019)Alzheimer's disease (AD) is the most common of the degenerative brain diseases and is described together with the impairment of cognitive function. Patients with AD lose the capability to code new memories, and life ... -
Synthesis and anticancer activity of some novel benzothiazole-thiazolidine derivatives
(Taylor & Francis LTD, 2018)Sixteen new 2-(benzothiazol-2-ylthio)-N-(3-substituted-4-(3,4-substitutedphenyl)thiazol-2(3H)-ylidene)acetohydrazide derivatives (4a-4p) were synthesized. The structures of the synthesized compounds were elucidated using ... -
Synthesis and Anticandidal Activity of New Imidazole-Chalcones
(MDPI, 2018)In the present work, 15 new 1-(4-(1H-imidazol-1-yl)phenyl)-3-(4-substituedphenyl) prop-2-en-1-one derivatives (3a-3o) were synthesized to evaluate their antifungal activity. Structures of newly synthesized imidazole ... -
Synthesis of New Benzothiazole Acylhydrazones as Anticancer Agents
(MDPI, 2018)During the last five decades, a large number of BT (Benzothiazole) derivatives formed one of the eligible structures in medicinal chemistry as anticancer agents. Most of the studies reveal that various substitutions at ... -
Synthesis and biological activities of new hydrazide derivatives
(Taylor & Francis LTD, 2009)The synthesis of a new series of imidazo[1,2-a]pyrazine-2-carboxylic acid arylidene-hydrazides is described. The chemical structures of the compounds were elucidated by IR, H-1-NMR, FAB(+)-MS spectral data. Their biological ... -
Comparative studies on conventional and microwave-assisted synthesis of a series of 2,4-di and 2,3,4-trisubstituted benzimidazol[1,2-a] pyrimidines and their antimicrobial activities
(Versita, 2009)Comparative studies were performed on a series of 2,41-di and 2,3,4-trisubstituted benzimidazo[1,2-a]pyrimidines, which were synthesized with conventional and microwave heating methods. In microwave irradiation method, ... -
Electrochemical Investigation of Interactions between Potential DNA Targeted Compounds, 2,4-Di- and 2,3,4-Trisubstituted Benzimidazo[1,2-a]pyrimidines and Nucleic Acid
(Japan Soc Analytical Chemistry, 2010)The electrochemical aspects of interactions between DNA and two organic compounds are discussed herein. Potential DNA targeted compounds, 2-methyl-4-phenyl-benzo[4,5]imidazo[1,2-a]pyrimidine (C1) and 2,3,4-trimethyl-benz ... -
Molecular modelling of 2-iminothiazoles as insecticidal activity
(Bulgarian Acad Science, 2017)Insecticides are used in agriculture, medicine, industry and by consumers, indoor. Insecticides are also claimed to be a major factor behind the increase in agricultural 20th century's productivity. On the other hand, modes ... -
Synthesis of Oxadiazole-Thiadiazole Hybrids and Their Anticandidal Activity
(MDPI AG, 2017)In the field of infection management, it is a major challenge to discover a potent and safe antifungal agent due to the emergence of resistant strains. Hence, the goal of this paper is to design and synthesize novel ... -
Novel 1-(2-pyrimidin-2-yl)piperazine derivatives as selective monoamine oxidase (MAO)-A inhibitors
(Taylor & Francis LTD, 2017)In the present study, a new series of 2-[4-(pyrimidin-2-yl) piperazin-1-yl]-2-oxoethyl 4-substituted piperazine- 1-carbodithioate derivatives (2a-n) were synthesized and screened for their monoamine oxidase A and B inhibitory ... -
Anticholinesterase activity screening of some novel dithiocarbamate derivatives including piperidine and piperazine moieties
(Taylor & Francis LTD, 2017)The present study was undertaken to synthesize some novel lipophilic piperazine and piperidinedithiocarbamates and investigate their inhibitory potencies against cholinesterase enzymes. In the synthetic studies, 44 new ... -
Synthesis and Anticancer Activities of Some Thiazole Derivatives
(Taylor & Francis LTD, 2009)In this study, 2-substituted 4-[3/4-(4-arylthiazole-2-yl) aminophenyl] thiazole derivatives and 2-[4-[2-substituted 4-methylthiazole-5-yl]thiazole-2-yl] amino-5-arylidenethiazoline-4-one derivatives have been synthesized. ... -
Synthesis of some 3,4-disubstituted-6,7-dihydro-imidazo[2,1-b][1,3]thiazole and 3,4-disubstituted-7,8-dihydro-6H-imidazo[2,1-b][1,3]thiazine derivatives and evaluation of their cytotoxicities against F2408 and 5RP7 cells
(Birkhauser Boston Inc, 2008)This article describes the synthesis of 3,4-disubstituted-6,7-dihydro-imidazo[2,1-b][1,3]thiazoles and 3,4-disubstituted-7,8-dihydro-6H-imidazo[2,1-b][1,3]thiazines, having substituted or nonsubstituted phenyl rings at the ... -
Design and Synthesis of New 1,3,4-Oxadiazole - Benzothiazole and Hydrazone Derivatives as Promising Chemotherapeutic Agents
(Georg Thieme Verlag Kg, 2017)Looking for new cytotoxic and antimicrobial agents with improved antitumor activity, a series of hydrazide and oxadiazole derivatives were designed and synthesized using 3-methoxyphenol as starting substance. Novel ... -
Synthesis of some novel 2-substituted benzothiazole derivatives containing benzylamine moiety as monoamine oxidase inhibitory agents
(Taylor & Francis LTD, 2016)In the present work, 12 new 2-(5-substituted-benzothiazol-2-ylsulfanyl)-N-(substitutedbenzyl)-N-(4-substitutedphenyl) acetamide derivatives (4a-l) was designed and synthesized. The structures of the synthesized compounds ... -
Synthesis and biological evaluation of some new pyrimidine bearing 2,5-disubstituted 1,3,4-oxadiazole derivatives as cytotoxic agents
(Walter De Gruyter GMBH, 2017)Objective: As a result of adverse effects including drug-resistance, toxicity and low bioavailability, there has been a crucial need for novel anticancer agents. In this present study, some novel 2,5-disubstituted ... -
Synthesis and Biological Evaluation of Novel Piperazine Containing Hydrazone Derivatives
(Hindawi LTD, 2016)Some hydrazone derivatives were synthesized and their potential anticholinesterase activities were examined. A series of eleven new compounds of N'-(2,4-disubstitutedbenzylidene)-2-(4-(4-nitrophenyl)piperazin-1-yl)acetohydrazide ... -
Synthesis and Anticandidal Activities of Some Aryl (5-Chloro-Benzofuran-2-yl) Ketoximes
(Bentham Science Publ LTD, 2019)Background: In this study, some aryl (5-chloro-benzofuran-2-yl) ketoximes and their ethers were synthesised to evaluate their antifungal activity against C. albicans, C. glabrata, C. krusei, and C. parapsilosis. Methods: ... -
Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Potent Antifungal Agents
(MDPI, 2018)With the goal of obtaining a novel bioactive compound with significant antifungal activity, a series of 1,3,4-thiadiazole derivatives (3a-3l) were synthesized and characterized. Due to thione-thiol tautomerism in the ...
