Ara
Toplam kayıt 348, listelenen: 331-340
Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Thiadiazole Derivatives as Potential Antitumor Agents against Chronic Myelogenous Leukemia: Striking Effect of Nitrothiazole Moiety
(MDPI, 2018)
In an attempt to develop potent antitumor agents, new 1,3,4-thiadiazole derivatives were synthesized and evaluated for their cytotoxic effects on multiple human cancer cell lines, including the K562 chronic myelogenous ...
Evaluation of antidepressant-like effect of 2-pyrazoline derivatives
(Birkhauser Boston Inc, 2010)
Many studies have shown that pyrazoline derivatives have therapeutic potential as antidepressant drugs. In this study, we aimed to investigate the antidepressant-like effect of eight new 1-[(N,N-disubstituted thiocarbamo ...
Synthesis and evaluation of new indole-based chalcones as potential antiinflammatory agents
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2015)
In the present work, new indole-based chalcone derivatives were obtained via the reaction of 5-substituted-1H-indole-3-carboxaldehydes/1-methylindole-3-carboxaldehyde with appropriate acetophenones. The synthesized compounds ...
Composition of the essential oil of Cistus parviflorus L. from Turkey
(Allured Publ Corp, 2004)
ater distilled essential oil of Cistus parviflorus L. from Turkey was analyzed by GC/MS. Seventy-six representing 89.4% of the oil were identified. 8-alpha-13-oxy-14-ene-epilabdane (18.2%), manoyl oxide (9.1%) and ...
Synthesis and AChE Inhibitory Activity of Novel Thiazolylhydrazone Derivatives
(MDPI, 2019)
Alzheimer's disease (AD) is the most common of the degenerative brain diseases and is described together with the impairment of cognitive function. Patients with AD lose the capability to code new memories, and life ...
Yeni benzotiyazol türevlerinin A549 akciğer karsinomu hücre hattına karşı antikanser etkinliğinin ilk basamak araştırması
(2017)
Amaç: Bu çalışmada, benzotiyazol-2-amin kalıntısının bilinen antiproliferatif özelliklerinden yola çıkılarak yeni kemoterapötik ajanların sentezlenmesi amaçlanmıştır. Yeni sentezlenen bileşiklerin antitümör etkinliği, A549 ...
New Benzodioxole-based Pyrazoline Derivatives: Synthesis and Anticandidal, In silico ADME, Molecular Docking Studies
(Bentham Science Publ LTD, 2019)
Background: Azoles are commonly used in the treatment and prevention of fungal infections. They suppress fungal growth by acting on the heme group of lanosterol 14 alpha-demethylase enzyme (CYP51), thus blocking the ...
Synthesis and evaluation of new pyrazoline-thiazole derivatives as monoamine oxidase inhibitors
(HeteroCorporation, 2019)
A novel series of 1,3,5-trisubstituted-2-pyrazoline derivatives (4a-4k) was synthesized and their chemical structures characterized by 1H NMR, 13C NMR, and mass spectroscopy. These compounds were evaluated as inhibitors ...
Designing of the new antithrombotic and also anticancer gold complexes
(Pergamon-Elsevier Science LTD, 2016)
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Antifungal, mosquito deterrent, and larvicidal activity of N-(benzylidene)-3-cyclohexylpropionic acid hydrazide derivatives
(Springer Birkhauser, 2013)
Hydrazone derivatives possess good antifungal and insecticidal activities and their structures are used in pesticide design. In the present study, for the first time, ten hydrazone derivatives (1-10) were evaluated for ...