Başlık için Farmasötik Kimya Anabilim Dalı listeleme
Toplam kayıt 345, listelenen: 24-43
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Biological Activity Evaluation of Novel 1,2,4-Triazine Derivatives Containing Thiazole/Benzothiazole Rings
(Bentham Science Publ LTD, 2017)Background: Triazine ring is a prominent structural motif found in some azanucleosides whose efficiency improved many times in the research area of antitumor agents. Objective: In this study, we have designed and synthesized ... -
Biological activity of some 4,5-di and 2,4,5-trisubstituted imidazole derivatives: Antihelmintic activity
(1988)[No abstract available] -
Biological evaluation of a series of benzothiazole derivatives as mosquitocidal agents
(Sciendo, 2019)Aedes aegypti is associated with the transmission of numerous human and animal diseases, such as yellow fever, dengue fever, chikungunya, and more recently Zika virus. Emerging insecticide resistance has created a need to ... -
Carbazoles and Hydrazone-Bridged Thiazole-Pyrrole Derivatives as New Inhibitors of alpha-Glucosidase
(Wiley-V C H Verlag GMBH, 2018)Carbazoles and hydrazone-bridged thiazole-pyrrole derivatives are known to exhibit a wide range of biological activities including antimicrobial activity. This work is a further extension of their biological activities ... -
Comparative studies on conventional and microwave-assisted synthesis of a series of 2,4-di and 2,3,4-trisubstituted benzimidazol[1,2-a] pyrimidines and their antimicrobial activities
(Versita, 2009)Comparative studies were performed on a series of 2,41-di and 2,3,4-trisubstituted benzimidazo[1,2-a]pyrimidines, which were synthesized with conventional and microwave heating methods. In microwave irradiation method, ... -
Composition of the essential oil of Cistus laurifolius L. from Turkey
(Allured Publ Corp, 2004)The water distilled essential oil of Cistus laurifolius L. from Turkey was analyzed by GC/MS. Sixty four compounds representing 67% of the oil were identified. Borneol (6.1%) and nonacosane (2.8%) were the major constituents. -
Composition of the essential oil of Cistus parviflorus L. from Turkey
(Allured Publ Corp, 2004)ater distilled essential oil of Cistus parviflorus L. from Turkey was analyzed by GC/MS. Seventy-six representing 89.4% of the oil were identified. 8-alpha-13-oxy-14-ene-epilabdane (18.2%), manoyl oxide (9.1%) and ... -
Crystal structure of [1-(1H-benzoimidazol-2-yl)-ethanone thiosemicarbazone]2nickel, [C20H22N10S2Ni]
(Japan Society for Analytical Chemistry, 2005)The title compound, [C20H22N10S2Ni], crystallizes in the triclinic space group P1 with cell parameters a = 10.9319(9)Å, b = 12.0083(9)Å, c = 13.4978(11)Å, ? = 87.057(7)°, ß = 85.841(7)°, ? = 63.820 (6), V = 1585.6(2)Å3, Z ... -
Cytotoxic and genotoxic effects of [Ru(phi)(3)](2+) evaluated by Ames/Salmonella and MTT methods
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2009)In this work, we synthesized and evaluated the cytotoxic effect of [Ru(phi)(3)](2+), on rat C6 glioma cell line. Cell viability was determined by assay with 3-(4-5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide ... -
Cytotoxic effects of some perimidine derivatives on F2408 and 5Rp7 cell lines
(2008)In this study twenty perimidine derivatives were prepared in order to seek their cytotoxic and antiproliferative effects on normal rat embryo fibroblast (F2408) and carcinogenic rat embryo fibroblast (5RP7) cell lines. ... -
Cytotoxic, Antiproliferative and Apoptotic Effects of New Benzimidazole Derivatives on A549 Lung Carcinoma and C6 Glioma Cell Lines
(Bentham Science Publ LTD, 2015)Benzimidazole ring is a versatile structure which has been extensively utilized in medicinal chemistry. Since we are working on 1,2-disubstutited benzimidazoles, we have reported new antitumor active derivatives. As a ... -
Design and Synthesis of New 1,3,4-Oxadiazole - Benzothiazole and Hydrazone Derivatives as Promising Chemotherapeutic Agents
(Georg Thieme Verlag Kg, 2017)Looking for new cytotoxic and antimicrobial agents with improved antitumor activity, a series of hydrazide and oxadiazole derivatives were designed and synthesized using 3-methoxyphenol as starting substance. Novel ... -
Design, synthesis and biological evaluation of new bis(thiosemicarbazone) derivatives as potential targeted anticancer agents for non-small cell lung cancer
(2020)Thiosemicarbazonesrepresent an important class of ligandsfortargeted therapyof many types of cancer including non-small celllung cancer. In order to identify potential antitumoragentsfor targeted therapy oflung cancer, new ... -
Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors
(Elsevier Masson SAS, 2019)Epidermal growth factor receptor (EGFR, also known as HER1) and HER2, prominent members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or prognostic markers in tumor progression. Based on ... -
Design, Synthesis and Biological Evaluation of Novel N-Pyridyl-Hydrazone Derivatives as Potential Monoamine Oxidase (MAO) Inhibitors
(MDPI, 2018)A new series of N-pyridyl-hydrazone derivatives was synthesized by using a simple and efficient method. The final compounds obtained were screened for their inhibitory potency against monoamine oxidase (MAO) A and B. The ... -
Design, synthesis and evaluation of new thiazole-piperazines as acetylcholinesterase inhibitors
(Informa Healthcare, 2013)In this study, some new 2-(4-substituted piperazine-1-yl)-N-[4-(2-methylthiazol-4-yl)phenyl]acetamide derivatives were synthesized. The synthesized compounds were screened for their anticholinesterase activity on ... -
Design, synthesis and in vitro evaluation of new thiosemicarbazone derivatives as potential anticancer agents
(Marmara University, 2019)Thiosemicarbazones play a pivotal role as potential therapeutic agents for the management of lung cancer. 4-(4-Cyanophenyl)-1-[(5-arylfuran-2-yl)methylene]thiosemicarbazides (1-10) were obtained via the reaction of ... -
Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Thiadiazole Derivatives as Potential Antitumor Agents against Chronic Myelogenous Leukemia: Striking Effect of Nitrothiazole Moiety
(MDPI, 2018)In an attempt to develop potent antitumor agents, new 1,3,4-thiadiazole derivatives were synthesized and evaluated for their cytotoxic effects on multiple human cancer cell lines, including the K562 chronic myelogenous ...
