Erişim şekli için "info:eu-repo/semantics/closedAccess" Farmasötik Kimya Anabilim Dalı listeleme
Toplam kayıt 268, listelenen: 21-40
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Biological Activity Evaluation of Novel 1,2,4-Triazine Derivatives Containing Thiazole/Benzothiazole Rings
(Bentham Science Publ LTD, 2017)Background: Triazine ring is a prominent structural motif found in some azanucleosides whose efficiency improved many times in the research area of antitumor agents. Objective: In this study, we have designed and synthesized ... -
Biological activity of some 4,5-di and 2,4,5-trisubstituted imidazole derivatives: Antihelmintic activity
(1988)[No abstract available] -
Carbazoles and Hydrazone-Bridged Thiazole-Pyrrole Derivatives as New Inhibitors of alpha-Glucosidase
(Wiley-V C H Verlag GMBH, 2018)Carbazoles and hydrazone-bridged thiazole-pyrrole derivatives are known to exhibit a wide range of biological activities including antimicrobial activity. This work is a further extension of their biological activities ... -
Composition of the essential oil of Cistus laurifolius L. from Turkey
(Allured Publ Corp, 2004)The water distilled essential oil of Cistus laurifolius L. from Turkey was analyzed by GC/MS. Sixty four compounds representing 67% of the oil were identified. Borneol (6.1%) and nonacosane (2.8%) were the major constituents. -
Composition of the essential oil of Cistus parviflorus L. from Turkey
(Allured Publ Corp, 2004)ater distilled essential oil of Cistus parviflorus L. from Turkey was analyzed by GC/MS. Seventy-six representing 89.4% of the oil were identified. 8-alpha-13-oxy-14-ene-epilabdane (18.2%), manoyl oxide (9.1%) and ... -
Cytotoxic and genotoxic effects of [Ru(phi)(3)](2+) evaluated by Ames/Salmonella and MTT methods
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2009)In this work, we synthesized and evaluated the cytotoxic effect of [Ru(phi)(3)](2+), on rat C6 glioma cell line. Cell viability was determined by assay with 3-(4-5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide ... -
Cytotoxic effects of some perimidine derivatives on F2408 and 5Rp7 cell lines
(2008)In this study twenty perimidine derivatives were prepared in order to seek their cytotoxic and antiproliferative effects on normal rat embryo fibroblast (F2408) and carcinogenic rat embryo fibroblast (5RP7) cell lines. ... -
Cytotoxic, Antiproliferative and Apoptotic Effects of New Benzimidazole Derivatives on A549 Lung Carcinoma and C6 Glioma Cell Lines
(Bentham Science Publ LTD, 2015)Benzimidazole ring is a versatile structure which has been extensively utilized in medicinal chemistry. Since we are working on 1,2-disubstutited benzimidazoles, we have reported new antitumor active derivatives. As a ... -
Design and Synthesis of New 1,3,4-Oxadiazole - Benzothiazole and Hydrazone Derivatives as Promising Chemotherapeutic Agents
(Georg Thieme Verlag Kg, 2017)Looking for new cytotoxic and antimicrobial agents with improved antitumor activity, a series of hydrazide and oxadiazole derivatives were designed and synthesized using 3-methoxyphenol as starting substance. Novel ... -
Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors
(Elsevier Masson SAS, 2019)Epidermal growth factor receptor (EGFR, also known as HER1) and HER2, prominent members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or prognostic markers in tumor progression. Based on ... -
Design, synthesis and evaluation of new thiazole-piperazines as acetylcholinesterase inhibitors
(Informa Healthcare, 2013)In this study, some new 2-(4-substituted piperazine-1-yl)-N-[4-(2-methylthiazol-4-yl)phenyl]acetamide derivatives were synthesized. The synthesized compounds were screened for their anticholinesterase activity on ... -
Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)In the current work, new 1,3,4-oxadiazole derivatives were synthesized and investigated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 mouse embryonic fibroblast cell lines. Compounds ... -
Design, synthesis, in vitro and in silico evaluation of new pyrrole derivatives as monoamine oxidase inhibitors
(Wiley-V C H Verlag GMBH, 2018)In an effort to develop potent monoamine oxidase (MAO) inhibitors, new pyrrole derivatives were obtained via the selective reduction of the CC bonds of 1-(1-methyl-1H-pyrrol-2-yl)-3-[5-(aryl)furan-2-yl]prop-2-en-1-ones ... -
Design, synthesis, monoamine oxidase inhibition and docking studies of new dithiocarbamate derivatives bearing benzylamine moiety
(Academic Press Inc Elsevier Science, 2018)A new series of thirteen 2-[(4-fluorophenyl)(4-nitrobenzyl) amino]-2-oxoethyl-1-substituted-carbodithio ate derivatives (4a-4m) were synthesized and tested for their human monoamine oxidase A and B (hMAO-A and hMAO-B) ... -
Designing of the new antithrombotic and also anticancer gold complexes
(Pergamon-Elsevier Science LTD, 2016)… -
Determination and evaluation of acid dissociation constants of some substituted 2-aminobenzothiazole derivatives
(American Chemical Society, 2008)The acid dissociation constants of some 4- and/or 6-substituted 2-aminobenzothiazole and 4-substituted thiazole derivatives were determined spectroscopically. With the exception of a few, the first protonation was found ... -
Erratum: Synthesis and Evaluation of Anti-acetylcholinesterase Activity of Some Benzothiazole Based New Piperazine-dithiocarbamate Derivatives (Drug Research (2015) DOI: 10.1055/s-0034-1375613)
(Georg Thieme Verlag, 2015)[No abstract available] -
Ethnobotany of Eskisehir and Its Environs
(Pakistan Botanical Soc, 2013)Eskisehir is located in the Central Anatolian province of Turkey. It is included in B3 grid square of Davis. There are more than 1000 plant taxa distributed in this State and its environs and nearly 220 are endemics. The ...