Kurum Yazarı "Özkay, Yusuf" Farmasötik Kimya Anabilim Dalı İçin Listeleme
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Synthesis and anticancer activity of some bisquinoxaline derivatives
Işıkdağ, İlhan; Özkay, Yusuf; İncesu, Zerrin (2011)Mevcut antikanser ajanlara karşı rezistans gelişimi, yeni antikanser ajanlar için bir araştırma alanı yaratmaktadır. Bununla birlikte, normal hücreler üzerinde etki göstermeden ya da en az etkiyle anormal hücrelerin ... -
Synthesis and anticancer activity of some bisquinoxaline derivatives [Bazi biskinoksalin türevlerinin sentezleri ve antikanser aktiviteleri]
Işıkdağ, İlhan; Özkay, Yusuf; Seller, Zerrin (2011)Resistance improvement against the existing anticancer agents creates a research area for new anticancer agents. Nevertheless, it is rather difficult to develop a new agent which can selectively inhibit the proliferation ... -
Synthesis and anticancer activity of some novel benzothiazole-thiazolidine derivatives
Osmaniye, Derya; Levent, Serkan; Ardıç, Cankiz Mina; Atlı Eklioğlu, Özlem; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2018)Sixteen new 2-(benzothiazol-2-ylthio)-N-(3-substituted-4-(3,4-substitutedphenyl)thiazol-2(3H)-ylidene)acetohydrazide derivatives (4a-4p) were synthesized. The structures of the synthesized compounds were elucidated using ... -
Synthesis and antimicrobial activity evaluation of new dithiocarbamate derivatives bearing thiazole/benzothiazole rings
Yurttaş, Leyla; Özkay, Yusuf; Duran, Murat; Turan, Gülhan; Özdemir, Ahmet; Cantürk, Zerrin; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2016)The synthesis of 2-(substituted phenyl)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (A1-A24) derivatives and 2-(4-substituted thiazol-2-ylamino)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (B1-B14) ... -
Synthesis and antimicrobial activity of benzimidazole-based acetamide derivatives
Altıntop, Mehlika Dilek; Abu Mohsen, Usama; Özkay, Yusuf; Demirel, Rasime; Kaplancıklı, Zafer Asım (Turkish Pharmacists Association, 2015)In the current work, new benzimidazole-based acetamide derivatives (2a-u) were synthesized and screened for their in vitro antimicrobial activity. Among these derivatives, compounds 2b-2g were found to be the most promising ... -
Synthesis and antimicrobial activity of derivatives of 2-((4-morpholinophenyl)amino)-2-oxoethyl piperazine-1-carbodithioate
Süleymanov, T. A.; Özkay, Yusuf; Shukurov, C. Y. (Azerbaijan Medical University, 2015)Derivatives of piperazine-1-carboditioate with morpholineaniline were synthesized and their structures were identified by elemental analysis, IR-, NMR- and MS-spectroscopy. The antimicrobial activity of synthesized derivatives ... -
Synthesis and antimicrobial activity of some new hydrazone-bridged thiazole-pyrrole derivatives
Yurttaş, Leyla; Özkay, Yusuf; Kaplancıklı, Zafer Asım; Tunalı, Yağmur; Karaca Gencer, Hülya (Taylor & Francis LTD, 2013)In this work, we synthesized fourteen different compounds which contain hydrazone bridged thiazole and pyrrole rings. For this purpose, pyrrole-2-carboxaldehydes were reacted directly with thiosemicarbazide in ethanol and ... -
Synthesis and Antimicrobial Activity of Some Novel Benzimidazole Hydrazides
Özkay, Yusuf; Tunalı, Yağmur; Karaca, H.; Işıkdağ, İlhan (Asian Journal Of Chemistry, 2011)The present study was undertaken to synthesize some 4-(5,6-dichloro-1H-benzimidazole-2-yl)phenoxyacetic acid-4-substituted benzylidene hydrazide derivatives and investigate their possible antimicrobial activity. Chemical ... -
Synthesis and Antimicrobial Evaluation of Some 2,5-Disubstituted Benzimidazole Derivatives
Yurttaş, Leyla; Özkay, Yusuf; Karaca, Hülya; Tunalı, Yağmur; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2013)Some benzimidazole derivatives bearing hydrazone moiety were synthesized and their in vitro antimicrobial activity was determined against various gram-positive and gram-negative bacteria, and fungi using microbroth dilution ... -
Synthesis and antiproliferative activity evaluation of new thiazole-benzimidazole derivatives using real-time cell analysis (RTCA DP)
Özkay, Yusuf; Yurttaş, Leyla; Dikmen, Miriş; EnGür, Selin (Springer Birkhauser, 2016)A series of new 2-[(5-substituted-1H-benzimidazol-2-yl)thio]-N-[4-[2-phenylthiazol-4-yl]phenyl]acetamide derivatives (4a-p) were synthesized according to the reported literature, and anticancer activity of the compounds ... -
Synthesis and biological activity of derivatives of 4-benzylpiperazine-1-dithiocarbamates
Süleymanov, T. A.; Özkay, Yusuf; Shukurov, C. Y. (Azerbaijan Medical University, 2014)Derivatives of 4-benzylpiperazine-l-dithiocarbamate were synthesized and their structures were identified by elemental analysis, IR-, NMR- and MS-spectroscopy. The biological activity of synthesized derivatives of ... -
Synthesis and Biological Evaluation of a Series of Dithiocarbamates as New Cholinesterase Inhibitors
Altıntop, Mehlika Dilek; Gürkan-Alp, A. Selen; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Wiley-V C H Verlag GMBH, 2013)In the present paper, a novel series of dithiocarbamates was synthesized via the treatment of 4-(trifluoromethyl)benzyl chloride with appropriate sodium salts of N,N-disubstituted dithiocarbamic acids. H-1 NMR, mass spectral ... -
Synthesis and Biological Evaluation of New Cholinesterase Inhibitors for Alzheimer's Disease
Hussein, Weiam; Sağlık, Begüm Nurpelin; Levent, Serkan; Korkut, Büsra; Ilgın, Sinem; Özkay, Yusuf; Kaplancıklı, Zafer Asım (MDPI, 2018)Alzheimer's disease (AD) is a neurodegenerative disorder mostly influencing the elderly, and causes death due to dementia. The main pathogenic feature connected with the progression of this multifactorial disease is the ... -
Synthesis and biological evaluation of new pyrazolone Schiff bases as monoamine oxidase and cholinesterase inhibitors
Tok, Fatih; Koçyiğit-Kaymakçıoğlu, Bedia; Sağlık, Begüm Nurpelin; Levent, Serkan; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Academic Press Inc Elsevier Science, 2019)In the current work, Schiff base derivatives of antipyrine were synthesized. The chemical characterization of the compounds was confirmed using IR, H-1 NMR, C-13 NMR and mass spectroscopies. The inhibitory potency of ... -
Synthesis and Biological Evaluation of Novel Piperazine Containing Hydrazone Derivatives
Kaya, Betül; Özkay, Yusuf; Temel, Halide Edip; Kaplancıklı, Zafer Asım (Hindawi LTD, 2016)Some hydrazone derivatives were synthesized and their potential anticholinesterase activities were examined. A series of eleven new compounds of N'-(2,4-disubstitutedbenzylidene)-2-(4-(4-nitrophenyl)piperazin-1-yl)acetohydrazide ... -
Synthesis and Biological Evaluation of Some New Amide Moiety Bearing Quinoxaline Derivatives as Antimicrobial Agents
Abu Mohsen, Usama; Yurttaş, Leyla; Acar, U.; Özkay, Yusuf; Kaplancıklı, Zafer Asım; Karaca Gencer, Hülya; Cantürk, Zerrin (Georg Thieme Verlag Kg, 2015)In this study, we aimed to synthesize some new quinoxaline derivatives bearing amide moiety and to evaluate their antimicrobial activity. A set of 16 novel compounds of N-[2,3-bis(4-methoxy/methylphenyl)quinoxalin-6-yl]- ... -
Synthesis and biological evaluation of some new mono Mannich bases with piperazines as possible anticancer agents and carbonic anhydrase inhibitors
Tugrak, Mehtap; Gül, Halise İnci; Bandow, Kenjiro; Sakagami, Hiroshi; Gülçin, İlhami; Özkay, Yusuf; Supuran, Claudiu T. (Academic Press Inc Elsevier Science, 2019)New mono Mannich bases, (2-(4-hydroxy-3-((4-substituephenylpiperazin-1-yl)methyl)benzylidene)-2,3-dihydro-1H-inden-1-one), were prepared to evaluate their cytotoxic/anticancer properties and also their inhibitory effects ... -
Synthesis and Biological Evaluation of Some Novel Dithiocarbamate Derivatives
Sağlık, Begüm Nurpelin; Özkay, Yusuf; Özkay, Ümide Demir; Karaca Gencer, Hülya (Hindawi LTD, 2014)18 novel dithiocarbamate derivatives were synthesized in order to investigate their inhibitory potency on acetylcholinesterase enzyme and antimicrobial activity. Structures of the synthesized compounds were elucidated by ... -
Synthesis and biological screening of some novel triazole derivatives
Acar, U.; Abu Mohsen, Usama; Özkay, Yusuf; Karaca, H.; Kaplancıklı, Zafer Asım (Turkish Pharmacists Association, 2015)In the present study 15 novel triazole compounds were synthesized in order to investigate their anticandidal and anticholinesterase activities. Structures of the synthesized compounds were elucidated by spectral data and ... -
Synthesis and Evaluation of Anti-acetylcholinesterase Activity of Some Benzothiazole Based New Piperazine-dithiocarbamate Derivatives
Mohsen, U. A.; Kaplancıklı, Zafer Asım; Özkay, Yusuf; Yurttaş, Leyla (Georg Thieme Verlag Kg, 2015)In this present study some benzothiazole derivatives bearing piperazine and thiocarbamate moieties were synthesized and their potential anticholinesterase properties were investigated. A set of 30 new compounds of ...